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Systematic Review Article

SARS-CoV-2大流行期间肠道微生物群生物校正的当前药物靶点：系统综述

卷 23, 期 11, 2022

发表于: 15 June, 2022

页: [1099 - 1125] 页: 27

弟呕挨: 10.2174/1389450123666220418094853

价格: $65

摘要

背景：众所周知，肠道微生物群在维持身体的体内平衡和增加其免疫抵抗力方面起着重要作用。它们在SARS-CoV-2感染过程中的作用尚未得到明确界定。 目的：本研究的目的是评估肠道微生物群，免疫反应性破坏和微生物群病理学与新的冠状病毒感染过程之间的致病关系，以证实在SARS-CoV-2大流行期间使用纠正肠道微生物群的当前药物。 材料和方法：世卫组织感染控制、全球卫生、科学指导、爱思唯尔、疾病预防控制中心感染疾病数据库、谷歌学院、“eLIBRARY.RU 科学电子图书馆”、MEDLINE、网络列宁卡、Embase、PubMed-NCBI、RSCI、Scopus和Cochrane图书馆的电子数据库用于这项分析研究。 结果：研究结果表明，正常的肠道微生物群是多级免疫防御系统的重要组成部分之一。肠道微生物群支持初始激活和准备的概念，以诱导对病原体（包括RNA病毒，如SARS-CoV-2）的入侵做出快速反应。目前的研究表明，肠道微生物群在COVID-19疾病严重程度的发病机制和预先确定中起着重要作用。通过产生必需代谢物和中和有毒底物，共生体调节所有器官和系统的功能，维持身体的体内平衡和免疫反应。肠道微生物群疾病决定了接种疫苗后抗COVID免疫的功效，特别是对SARS-CoV-2的易感性和这种感染的严重程度。这是通过分泌性免疫球蛋白和微生物组的获得性免疫来刺激局部肠道免疫反应来完成的。人口中生态失调的高患病率表明，在SARS-CoV-2大流行期间，有必要定期进行肠道微生物群生物校正。我们对当前纠正肠道微生物群的生物制剂的系统综述为执业临床医生提供了有价值的参考，以快速指定和开发各种药物，评估其能力，并为有SARS-CoV-2感染风险的患者选择最佳治疗方法。 结论：目前的数据支持这样一种观点，即肠道菌群生物校正可能有助于在SARS-CoV-2大流行期间提高人群免疫力并保护公共卫生。

关键词: SARS-CoV-2，生态失调，身体稳态，免疫抵抗，疫苗接种，肠道微生物群生物校正，公共卫生

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