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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Mini-Review Article

1,2,3-Triazole Derivatives with Anti-breast Cancer Potential

Author(s): Xinyi Wu, Jun Wang*, Shiqi Xia, Shishuo Cheng and Yumin Shi

Volume 22, Issue 17, 2022

Published on: 31 May, 2022

Page: [1406 - 1425] Pages: 20

DOI: 10.2174/1568026622666220415225334

Price: $65

Abstract

Breast cancer is one of the most prevalent malignant diseases, and one of the main causes of mortality among women across the world. Despite advances in chemotherapy, drug resistance remains a major clinical concern, creating an urgent need to explore novel anti-breast cancer drugs. 1,2,3-triazole is a privileged moiety, and its derivatives could inhibit cancer cell proliferation and induce cell cycle arrest and apoptosis. Accordingly, 1,2,3-triazole derivatives possess profound activity against various cancers, including breast cancer. This review summarizes the latest progress related to the anti-breast cancer potential of 1,2,3-triazole derivatives, covering articles published from January 2017 to December 2021. The mechanisms of action and structure-activity relationships (SARs) are also discussed for the further rational design of more effective candidates.

Keywords: 1, 2, 3-Triazole, Breast cancer, Mechanisms of action, Structure-activity relationship, Heterogeneous disease, Chemotherapy.

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