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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

胃癌代谢研究进展及治疗意义

卷 22, 期 9, 2022

发表于: 09 June, 2022

页: [703 - 716] 页: 14

弟呕挨: 10.2174/1568009622666220413083534

价格: $65

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摘要

背景：在全球范围内，胃癌的发病率位居恶性肿瘤的第五位，死亡率位居第三位。胃癌会导致可用于治疗的新陈代谢改变。 目的：本研究的目的是概述胃癌引起的显着代谢改变并提出阻断措施。 方法：对胃癌及其阻断引起的代谢改变的描述性和实验性出版物进行全面和最新的审查。这不是系统评价。 结果：胃癌导致糖酵解和谷氨酰胺分解的高发生率。脂肪酸从头合成和胆固醇合成的速率增加。此外，胃癌通过脂肪酸β-氧化导致脂质周转率高。临床前数据表明，通过酶靶向单独阻断这些途径会在体外和体内产生抗肿瘤作用。然而，没有关于同时阻断这五种途径的数据，这是至关重要的，因为肿瘤在响应营养物质的可用性时表现出代谢灵活性。这意味着当一种或多种被抑制时，肿瘤可能会激活替代途径。我们假设需要同时阻断它们以避免或降低可能导致治疗抵抗的代谢灵活性。 结论：有必要探索针对葡萄糖、谷氨酰胺、脂肪酸合成、胆固醇合成和脂肪酸氧化途径的联合代谢疗法的临床前疗效和可行性。这可能具有治疗意义，因为我们有针对胃癌这些途径的临床可用药物。

关键词: 胃癌、糖酵解、谷氨酰胺分解、脂质、代谢阻断、新陈代谢。

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图形摘要

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