Generic placeholder image

Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Perspective

Potential Clinical Role of Prokineticin 2 (PK2) in Neurodegenerative Diseases

Author(s): Daniela Maftei, Tommaso Schirinzi, Nicola B. Mercuri, Roberta Lattanzi and Cinzia Severini*

Volume 20, Issue 11, 2022

Published on: 18 August, 2022

Page: [2019 - 2023] Pages: 5

DOI: 10.2174/1570159X20666220411084612

Abstract

The role of the immune system in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) has become clear in recent decades, as evidenced by the presence of activated microglia and astrocytes and numerous soluble mediators in the brain and peripheral tissues of affected patients. Among inflammatory mediators, chemokines play a central role in neuroinflammation due to their dual function as chemoattractants for immune cells and molecular messengers in crosstalk among CNS-resident cells. The chemokine Bv8/Prokineticin 2 (PK2) has recently emerged as an important player in many age-related and chronic diseases that are either neurodegenerative or systemic. In this perspective paper, we briefly discuss the role that PK2 and its cognate receptors play in AD and PD animal models and in patients. Given the apparent changes in PK2 blood levels in both AD and PD patients, the potential clinical value of PK2 either as a disease biomarker or as a therapeutic target for these disorders is discussed.

Keywords: Prokyneticin 2, neuroinflammation, Alzheimer’s disease, Parkinson’s disease, therapeutic targets, clinical biomarkers.

[1]
Mortada, I.; Farah, R.; Nabha, S.; Ojcius, D.M.; Fares, Y.; Almawi, W.Y.; Sadier, N.S. Immunotherapies for Neurodegenerative Diseases. Front. Neurol., 2021, 12, 654739.
[http://dx.doi.org/10.3389/fneur.2021.654739] [PMID: 34163421]
[2]
Nimmo, J.T.; Kelly, L.; Verma, A.; Carare, R.O.; Nicoll, J.A.R.; Dodart, J.C. Amyloid-β and α-synuclein immunotherapy: From experimental studies to clinical trials. Front. Neurosci., 2021, 15, 733857.
[http://dx.doi.org/10.3389/fnins.2021.733857] [PMID: 34539340]
[3]
Yiannopoulou, K.G.; Anastasiou, A.I.; Zachariou, V.; Pelidou, S.H. Reasons for failed trials of disease-modifying treatments for Alzheimer disease and their contribution in recent research. Biomedicines, 2019, 7(4), 97.
[http://dx.doi.org/10.3390/biomedicines7040097] [PMID: 31835422]
[4]
Krashia, P.; Cordella, A.; Nobili, A.; La Barbera, L.; Federici, M.; Leuti, A.; Campanelli, F.; Natale, G.; Marino, G.; Calabrese, V.; Vedele, F.; Ghiglieri, V.; Picconi, B.; Di Lazzaro, G.; Schirinzi, T.; Sancesario, G.; Casadei, N.; Riess, O.; Bernardini, S.; Pisani, A.; Calabresi, P.; Viscomi, M.T.; Serhan, C.N.; Chiurchiù, V.; D’Amelio, M.; Mercuri, N.B. Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease. Nat. Commun., 2019, 10(1), 3945.
[http://dx.doi.org/10.1038/s41467-019-11928-w] [PMID: 31477726]
[5]
Petrillo, S.; Schirinzi, T.; Di Lazzaro, G.; D’Amico, J.; Colona, V.L.; Bertini, E.; Pierantozzi, M.; Mari, L.; Mercuri, N.B.; Piemonte, F.; Pisani, A. Systemic Activation of Nrf2 Pathway in Parkinson’s Disease. Mov. Disord., 2020, 35(1), 180-184.
[http://dx.doi.org/10.1002/mds.27878] [PMID: 31682033]
[6]
Schirinzi, T.; Maftei, D.; Ralli, M.; Greco, A.; Mercuri, N.B.; Lattanzi, R.; Severini, C. Serum Substance P Is Increased in Parkinson’s Disease and Correlates with Motor Impairment. Mov. Disord., 2022, 37(1), 228-230.
[http://dx.doi.org/10.1002/mds.28458] [PMID: 34623702]
[7]
Sancesario, G.M.; Di Lazzaro, G.; Grillo, P.; Biticchi, B.; Giannella, E.; Alwardat, M.; Pieri, M.; Bernardini, S.; Mercuri, N.B.; Pisani, A.; Schirinzi, T. Biofluids profile of α-Klotho in patients with Parkinson’s disease. Parkinsonism Relat. Disord., 2021, 90, 62-64.
[http://dx.doi.org/10.1016/j.parkreldis.2021.08.004] [PMID: 34392132]
[8]
Ransohoff, R.M. How neuroinflammation contributes to neurodegeneration. Science, 2016, 353(6301), 777-783.
[http://dx.doi.org/10.1126/science.aag2590] [PMID: 27540165]
[9]
Severini, C.; Passeri, P.P.; Ciotti, M.; Florenzano, F.; Possenti, R.; Zona, C.; Di Matteo, A.; Guglielmotti, A.; Calissano, P.; Pachter, J.; Mercanti, D. Bindarit, inhibitor of CCL2 synthesis, protects neurons against amyloid-β-induced toxicity. J. Alzheimers Dis., 2013, 38(2), 281-293.
[http://dx.doi.org/10.3233/JAD-131070] [PMID: 23948942]
[10]
Severini, C.; Barbato, C.; Di Certo, M.G.; Gabanella, F.; Petrella, C.; Di Stadio, A.; de Vincentiis, M.; Polimeni, A.; Ralli, M.; Greco, A. Alzheimer’s Disease: New Concepts on the Role of Autoimmunity and NLRP3 Inflammasome in the Pathogenesis of the Disease. Curr. Neuropharmacol., 2021, 19(4), 498-512.
[http://dx.doi.org/10.2174/1570159X18666200621204546] [PMID: 32564756]
[11]
Zuena, A.R.; Casolini, P.; Lattanzi, R.; Maftei, D. Chemokines in Alzheimer’s disease: New insights into prokineticins, chemokine-like proteins. Front. Pharmacol., 2019, 10, 622.
[http://dx.doi.org/10.3389/fphar.2019.00622] [PMID: 31231219]
[12]
Negri, L.; Ferrara, N. The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis. Physiol. Rev., 2018, 98(2), 1055-1082.
[http://dx.doi.org/10.1152/physrev.00012.2017] [PMID: 29537336]
[13]
Désaubry, L.; Kanthasamy, A.G.; Nebigil, C.G. Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain injuries. Pharmacol. Res., 2020, 160, 105190.
[http://dx.doi.org/10.1016/j.phrs.2020.105190] [PMID: 32937177]
[14]
Lattanzi, R.; Severini, C.; Maftei, D.; Saso, L.; Badiani, A. The Role of Prokineticin 2 in Oxidative Stress and in Neuropathological Processes. Front. Pharmacol., 2021, 12, 640441.
[http://dx.doi.org/10.3389/fphar.2021.640441] [PMID: 33732160]
[15]
Lattanzi, R.; Maftei, D.; Petrella, C.; Pieri, M.; Sancesario, G.; Schirinzi, T.; Bernardini, S.; Barbato, C.; Ralli, M.; Greco, A.; Possenti, R.; Sancesario, G.; Severini, C. Involvement of the chemokine prokineticin-2 (PROK2) in Alzheimer’s disease: From animal models to the human pathology. Cells, 2019, 8(11), 1430.
[http://dx.doi.org/10.3390/cells8111430] [PMID: 31766244]
[16]
Scheltens, P.; De Strooper, B.; Kivipelto, M.; Holstege, H.; Chételat, G.; Teunissen, C.E.; Cummings, J.; van der Flier, W.M. Alzheimer’s disease. Lancet, 2021, 397(10284), 1577-1590.
[http://dx.doi.org/10.1016/S0140-6736(20)32205-4] [PMID: 33667416]
[17]
Johnstone, M.; Gearing, A.J.H.; Miller, K.M. A central role for astrocytes in the inflammatory response to β-amyloid; chemokines, cytokines and reactive oxygen species are produced. J. Neuroimmunol., 1999, 93(1-2), 182-193.
[http://dx.doi.org/10.1016/S0165-5728(98)00226-4] [PMID: 10378882]
[18]
Severini, C.; Lattanzi, R.; Maftei, D.; Marconi, V.; Ciotti, M.T.; Petrocchi Passeri, P.; Florenzano, F.; Del Duca, E.; Caioli, S.; Zona, C.; Balboni, G.; Salvadori, S.; Nisticò, R.; Negri, L. Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity. Sci. Rep., 2015, 5(1), 15301.
[http://dx.doi.org/10.1038/srep15301] [PMID: 26477583]
[19]
Caioli, S.; Severini, C.; Ciotti, T.; Florenzano, F.; Pimpinella, D.; Petrocchi Passeri, P.; Balboni, G.; Polisca, P.; Lattanzi, R.; Nisticò, R.; Negri, L.; Zona, C. Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer’s disease. Neuropharmacology, 2017, 116, 82-97.
[http://dx.doi.org/10.1016/j.neuropharm.2016.12.012] [PMID: 27989680]
[20]
Maftei, D.; Ratano, P.; Fusco, I.; Marconi, V.; Squillace, S.; Negri, L.; Severini, C.; Balboni, G.; Steardo, L.; Bronzuoli, M.R.; Scuderi, C.; Campolongo, P.; Lattanzi, R. The prokineticin receptor antagonist PC1 rescues memory impairment induced by β amyloid administration through the modulation of prokineticin system. Neuropharmacology, 2019, 158, 107739.
[http://dx.doi.org/10.1016/j.neuropharm.2019.107739] [PMID: 31408628]
[21]
Schirinzi, T.; Sancesario, G.M.; Di Lazzaro, G.; Biticchi, B.; Colona, V.L.; Mercuri, N.B.; Bernardini, S.; Pisani, A. CSF α-synuclein inversely correlates with non-motor symptoms in a cohort of PD patients. Parkinsonism Relat. Disord., 2019, 61, 203-206.
[http://dx.doi.org/10.1016/j.parkreldis.2018.10.018] [PMID: 30348495]
[22]
Gordon, R.; Neal, M.L.; Luo, J.; Langley, M.R.; Harischandra, D.S.; Panicker, N.; Charli, A.; Jin, H.; Anantharam, V.; Woodruff, T.M.; Zhou, Q.Y.; Kanthasamy, A.G.; Kanthasamy, A. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nat. Commun., 2016, 7(1), 12932.
[http://dx.doi.org/10.1038/ncomms12932] [PMID: 27703142]
[23]
Schirinzi, T.; Maftei, D.; Pieri, M.; Bernardini, S.; Mercuri, N.B.; Lattanzi, R.; Severini, C. Increase of prokineticin‐2 in serum of patients with Parkinson’s disease. Mov. Disord., 2021, 36(4), 1031-1033.
[http://dx.doi.org/10.1002/mds.28458]
[24]
Ng, K.L.; Li, J.D.; Cheng, M.Y.; Leslie, F.M.; Lee, A.G.; Zhou, Q.Y. Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science, 2005, 308(5730), 1923-1927.
[http://dx.doi.org/10.1126/science.1112103] [PMID: 15976302]
[25]
Fullard, M.E.; Morley, J.F.; Duda, J.E. Olfactory dysfunction as an early biomarker in Parkinson’s disease. Neurosci. Bull., 2017, 33(5), 515-525.
[http://dx.doi.org/10.1007/s12264-017-0170-x] [PMID: 28831680]
[26]
Watson, R.P.; Lilley, E.; Panesar, M.; Bhalay, G.; Langridge, S.; Tian, S.S.; McClenaghan, C.; Ropenga, A.; Zeng, F.; Nash, M.S. Increased prokineticin 2 expression in gut inflammation: Role in visceral pain and intestinal ion transport. Neurogastroenterol. Motil., 2012, 24(1), 65-e12-e12.
[http://dx.doi.org/10.1111/j.1365-2982.2011.01804.x] [PMID: 22050240]
[27]
Horsager, J.; Andersen, K.B.; Knudsen, K.; Skjærbæk, C.; Fedorova, T.D.; Okkels, N.; Schaeffer, E.; Bonkat, S.K.; Geday, J.; Otto, M.; Sommerauer, M.; Danielsen, E.H.; Bech, E.; Kraft, J.; Munk, O.L.; Hansen, S.D.; Pavese, N.; Göder, R.; Brooks, D.J.; Berg, D.; Borghammer, P. Brain-first versus body-first Parkinson’s disease: A multimodal imaging case-control study. Brain, 2020, 143(10), 3077-3088.
[http://dx.doi.org/10.1093/brain/awaa238] [PMID: 32830221]
[28]
Imbriani, P.; D’Angelo, V.; Platania, P.; Di Lazzaro, G.; Scalise, S.; Salimei, C.; El Atiallah, I.; Colona, V.L.; Mercuri, N.B.; Bonsi, P.; Pisani, A.; Schirinzi, T.; Martella, G. Ischemic injury precipitates neuronal vulnerability in Parkinson’s disease: Insights from PINK1 mouse model study and clinical retrospective data. Parkinsonism Relat. Disord., 2020, 74, 57-63.
[http://dx.doi.org/10.1016/j.parkreldis.2020.04.004] [PMID: 32335490]
[29]
Schirinzi, T.; Grillo, P.; Di Lazzaro, G.; Zenuni, H.; Salimei, C.; Dams-O’Connor, K.; Sancesario, G.M.; Mercuri, N.B.; Pisani, A. Effects of head trauma and sport participation in young-onset Parkinson’s disease. J. Neural Transm. (Vienna), 2021, 128(8), 1185-1193.
[http://dx.doi.org/10.1007/s00702-021-02370-8] [PMID: 34263354]
[30]
Yang, Z.; Wang, M.; Zhang, Y.; Cai, F.; Jiang, B.; Zha, W.; Yu, W. Metformin ameliorates diabetic cardiomyopathy by activating the PK2/PKR pathway. Front. Physiol., 2020, 11, 425.
[http://dx.doi.org/10.3389/fphys.2020.00425] [PMID: 32508669]
[31]
Paudel, Y.N.; Angelopoulou, E.; Piperi, C.; Shaikh, M.F.; Othman, I. Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk. Pharmacol. Res., 2020, 152, 104593.
[http://dx.doi.org/10.1016/j.phrs.2019.104593] [PMID: 31843673]
[32]
Magnusen, A.F.; Hatton, S.L.; Rani, R.; Pandey, M.K. Genetic defects and pro-inflammatory cytokines in Parkinson’s disease. Front. Neurol., 2021, 12, 636139.
[http://dx.doi.org/10.3389/fneur.2021.636139] [PMID: 34239490]

© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version577msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[18:56:28] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[18:56:28] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[18:56:28] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[18:56:28] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[18:56:28] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (145ms)time
  • Application (432ms)time
  • 1 x Application (74.88%)
    432ms
    1 x Booting (25.12%)
    145ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    31 statements were executed, 4 of which were duplicates, 27 unique. Show only duplicated323ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314482634','',1,1740423388,1740423388) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740423388
      1.29msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314482634','/article/122441',1,1740423388,1740423388)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314482634 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314482634) limit 1
      23.42msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314482634
      • 1: 314482634
      • 2: 314482634
      • 3: 314482634
      • 4: 314482634
      • 5: 314482634
      • 6: 314482634
      • 7: 314482634
      • 8: 314482634
      • 9: 314482634
      • 10: 314482634
      • 11: 314482634
      • 12: 314482634
      • 13: 314482634
      • 14: 314482634
      • 15: 314482634
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=122441
      3.78msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 26 limit 1
      1.42msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 26
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and sj.journal_id!=26 group by `j`.`nid`) as `aggregate_table`
      10.32msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and sj.journal_id!=26 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      1.55msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      21.99msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      84.63msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '122441'
      1.59msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 122441
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '122441'
      26.75msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 122441
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '122441' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      10.3msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 122441
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      450μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      1.31msalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 26 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      92.57msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 26 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      17.16msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 26 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      12.15msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 122441 limit 1
      960μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 122441
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 122441 and content_type = 'article' order by status desc limit 1
      400μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 203367 limit 1
      280μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 203367
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      340μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CN' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      300μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CN
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '122441' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      490μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '2019' and is_uploaded = 1 and issue_id = 11844 order by cast(first_page as SIGNED) desc limit 1
      610μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 2019
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '2023' and is_uploaded = 1 and issue_id = 11844 order by cast(first_page as SIGNED) asc limit 1
      540μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 2023
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      210μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      320μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 122441 limit 1
      2.42msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 122441
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 26 and `b`.`banner_from_date` <= 1740423388 and `b`.`banner_to_date` >= 1740423388 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.69msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 26
      • 3: 1740423388
      • 4: 1740423388
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 26 and `b`.`banner_from_date` <= 1740423388 and `b`.`banner_to_date` >= 1740423388 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      3.28msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 26
      • 3: 1740423388
      • 4: 1740423388
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='138975372eca49b2fb146f95ceb3fbed'
      280μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        1tps6bmd42vsquBbZJ7z0SzlqCMuIco1jVyUTZ9B
        uc_cart_id
        138975372eca49b2fb146f95ceb3fbed
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/122441" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/122441
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 24 Feb 2025 18:56:28 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkJjak5abjUzbWo5V1Y5ZElPbU5LWVE9PSIsInZhbHVlIjoiT0FoOWJGS3g0ZUU5V25zdmtScVRSL2grSi9kWG5rSDZLc01ieTR1UGwzM2U5MFhaTGpGUUhwdXVoM09Qa1RLV3NoMHg1aEJ3bndsRUJGa2d5RTFhRzRQWCt4ZmNsS21WNlE0ZU5CM0hzN3oxYmRoaW9FaGlIeWt0cFFWanJNWkEiLCJtYWMiOiIwMjMwZjVjMGQ2ZWVhMjcwMDJkY2YwYWZmMGQyN2VhMGM1NmI3NjE4YmM3ZmM0MTc0N2E2YjlmMmQwZGEyOGIzIiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 06:56:28 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkJjak5abjUzbWo5V1Y5ZElPbU5LWVE9PSIsInZhbHVlIjoiT0FoOWJGS3g0ZUU5V25zdmtScVRSL2grSi9kWG5rSDZLc01ieTR1UGwzM2U5MFhaTGpGUUhwdXVoM09Qa1RLV3NoMHg1a" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkRlYVlIcFlVZHNHTVVuNkFaQ1RMU0E9PSIsInZhbHVlIjoiazdza2JIRFFwc0E2YmpldWxJbVpvTkZzVVlSQ0FQN0ZqR1JvaXhXYkJ3M0srNHdHeGhEdDNLRklYbDB6U1FZano4WHlTTm5FTnk3aDB2RGFja3hHYStMZnd5Qmg4UDVBTGU1MVRRSC9PajRHbTFsdkdwRmFienU5NllrTTViTFoiLCJtYWMiOiJlODRlMDMwY2NmNjU0ZTk0NDE0NjM2NTQzNTk0OWUxZGU0MTdhMGRhY2M3Yzk3NGExYWRhZWJiMWE3NDllOTA1IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IkRlYVlIcFlVZHNHTVVuNkFaQ1RMU0E9PSIsInZhbHVlIjoiazdza2JIRFFwc0E2YmpldWxJbVpvTkZzVVlSQ0FQN0ZqR1JvaXhXYkJ3M0srNHdHeGhEdDNLRkl" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkJjak5abjUzbWo5V1Y5ZElPbU5LWVE9PSIsInZhbHVlIjoiT0FoOWJGS3g0ZUU5V25zdmtScVRSL2grSi9kWG5rSDZLc01ieTR1UGwzM2U5MFhaTGpGUUhwdXVoM09Qa1RLV3NoMHg1aEJ3bndsRUJGa2d5RTFhRzRQWCt4ZmNsS21WNlE0ZU5CM0hzN3oxYmRoaW9FaGlIeWt0cFFWanJNWkEiLCJtYWMiOiIwMjMwZjVjMGQ2ZWVhMjcwMDJkY2YwYWZmMGQyN2VhMGM1NmI3NjE4YmM3ZmM0MTc0N2E2YjlmMmQwZGEyOGIzIiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 06:56:28 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkJjak5abjUzbWo5V1Y5ZElPbU5LWVE9PSIsInZhbHVlIjoiT0FoOWJGS3g0ZUU5V25zdmtScVRSL2grSi9kWG5rSDZLc01ieTR1UGwzM2U5MFhaTGpGUUhwdXVoM09Qa1RLV3NoMHg1a" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkRlYVlIcFlVZHNHTVVuNkFaQ1RMU0E9PSIsInZhbHVlIjoiazdza2JIRFFwc0E2YmpldWxJbVpvTkZzVVlSQ0FQN0ZqR1JvaXhXYkJ3M0srNHdHeGhEdDNLRklYbDB6U1FZano4WHlTTm5FTnk3aDB2RGFja3hHYStMZnd5Qmg4UDVBTGU1MVRRSC9PajRHbTFsdkdwRmFienU5NllrTTViTFoiLCJtYWMiOiJlODRlMDMwY2NmNjU0ZTk0NDE0NjM2NTQzNTk0OWUxZGU0MTdhMGRhY2M3Yzk3NGExYWRhZWJiMWE3NDllOTA1IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IkRlYVlIcFlVZHNHTVVuNkFaQ1RMU0E9PSIsInZhbHVlIjoiazdza2JIRFFwc0E2YmpldWxJbVpvTkZzVVlSQ0FQN0ZqR1JvaXhXYkJ3M0srNHdHeGhEdDNLRkl" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "1tps6bmd42vsquBbZJ7z0SzlqCMuIco1jVyUTZ9B" "uc_cart_id" => "138975372eca49b2fb146f95ceb3fbed" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/122441" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-24 18:56:28GET/article/122441514311