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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Systematic Review Article

Co-infections of Schistosoma spp. and Malaria with Hepatitis Viruses from Endemic Countries: A Systematic Review and Meta-Analysis

Author(s): Ali Taghipour, Saeed Bahadory, Meysam Olfatifar, Mojtaba Norouzi, Hamidreza Majidiani* and Masoud Foroutan*

Volume 22, Issue 6, 2022

Published on: 25 May, 2022

Article ID: e060422203194 Pages: 8

DOI: 10.2174/1871526522666220406122742

Price: $65

Abstract

Background: Co-infection of schistosomiasis and malaria with hepatitis B virus (HBV) and hepatitis C virus (HCV) are common in countries where schistosomiasis and malaria are endemic.

Objective: The present systematic review and meta-analysis was conducted to assess the prevalence of malaria/hepatitis viruses and Schistosoma/hepatitis viruses’ co-infections.

Materials and Methods: Relevant published studies on the co-infection of malaria and Schistosoma spp. with HBV and HCV were retrieved via international databases (PubMed, Scopus, Web of Science, and Google Scholar). Regarding meta-analysis, the random‐effect model was employed by forest plot with a 95% of confidence interval (CI).

Results: A total of 22 studies, including 15 studies with malaria/hepatitis viruses’ co-infection and 7 studies with Schistosoma/hepatitis viruses’ co-infection met the eligibility criteria. The co-infection of malaria/HCV and malaria/HBV in different populations were 15% (95% CI, 0-77%) and 5% (95% CI, 1-10%), respectively. Moreover, Schistosoma/HCV and Schistosoma/HBV co infection were detected in 7% (95% CI, 0-54%) and 2% (95% CI, 0-7%), respectively.

Conclusion: The overlaps between Schistosoma spp. and malaria with hepatitis B and C viruses in endemic countries with lower income levels were high, which deserve further attention.

Keywords: Co-infection, Schistosoma spp., malaria, hepatitis B virus, hepatitis C virus, subtropical areas.

Graphical Abstract

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