Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Review Article

Phytopharmacological Review of a Food Supplement Zingiber officinale Roscoe (Zingiberaceae)

Author(s): Vasudev Pai, Chandrashekar Kodangala Subraya*, Baby Sai Sri and Aswatha Ram Holavana Halli Nanjundaiah

Volume 18, Issue 8, 2022

Published on: 25 May, 2022

Page: [746 - 751] Pages: 6

DOI: 10.2174/1573401318666220401112105

Price: $65

Abstract

Zingiber officinale, a medicinal herb commonly used in Ayurveda belongs to family Zingiberaceae and is reported to have various therapeutic properties. Roots as well as rhizomes of this plant are commonly used in the treatment of digestive disorder. It has also been used as expectorant, spasmolytic, anti-tussive, anti-allergic, antihistaminic activity and inhibits coughing. The roots and rhizomes are rich sources of essential oil, which may be one of the reasons for medicinal properties. Required data on this plant were obtained from electronic sources (google scholar, PubMed, Scopus, Web of Science), several classical textbooks on Ayurveda, and ethnopharmacology. This review article covers all the relevant information on its pharmacological and phytochemical aspects. In this study, we have critically reviewed recent advancements of Zingiber officinale in an attempt to authenticate its use as a multipurpose therapeutic ingredient.

Keywords: Zingiber officinale, essential oil, pharmacological activities, phytochemistry, ginger, ethnomedicinal uses, Adrakam.

Graphical Abstract

[1]
Kokate CK, Purohit AP, Gokhele SB. Pharmacognosy. 37th ed. Pune: Nirali Prakashan 2007; pp. 395-8.
[2]
Joy PP, Thomas J, Samuel M, Gim J, Joseoh J. Aromatic Plants, Aromatic and Medicinal Plants Research Station. Asamannoor, Kerala, India: Odakkali 1998; p. 30.
[3]
Indian Council of Medical Research. Quality Standards of Indian Medicinal Plants. New Delhi 2010; pp. 34-349.
[4]
Rajpal P. Testing and extraction methods of medicinal herbs- Standardization of Botanicals Standardization of Botanicals 1: 262-72.
[5]
Gupta DP. The Herbs-Habitat, Morphology and Pharmacognosy of most important popular Indian medicinal plant. 1st ed. Madhya Pradesh: Printwell Offset Publisher 2008; pp. 472-4.
[6]
Mohamad HS, Wenli S, Cheng Q. Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta Agriculturae Scandinavica, Section B - Soil & Plant Science 2019; 69: 546-56.
[7]
Yoshikawa M, Hatakeyama S, Taniguchi K, Matuda H, Yamahara J. 6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in Taiwan. Chem Pharm Bull (Tokyo) 1992; 40(8): 2239-41.
[http://dx.doi.org/10.1248/cpb.40.2239] [PMID: 1423791]
[8]
Katsuya E, Emi K, Yoshiteru O. Structures of antifungal diarylheptenones, gingerenones A, B, C and isogingerenone B, isolated from the rhizomes of Zingiber officinale. Phytochemistry 1990; 29(3): 797-9.
[http://dx.doi.org/10.1016/0031-9422(90)80021-8]
[9]
Ajith TA, Hema U, Aswathy MS. Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem Toxicol 2007; 45(11): 2267-72.
[http://dx.doi.org/10.1016/j.fct.2007.06.001] [PMID: 17637489]
[10]
Ajith TA, Aswathy MS, Hema U. Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food Chem Toxicol 2008; 46(9): 3178-81.
[http://dx.doi.org/10.1016/j.fct.2008.07.004] [PMID: 18680783]
[11]
Giuffrè AM, Caracciolo M, Zappia C, Capocasale M, Poiana M. Effect of heating on chemical parameters of extra virgin olive oil, pomace olive oil, soybean oil and palm oil. Italian J Food Sci 2018; 30(4): 715-39.
[http://dx.doi.org/10.14674/IJFS-1269]
[12]
Stoilovaa I, Krastanova A, Stoyanova A, Denevc P, Gargova S. Antioxidant activity of a ginger extract (Zingiber officinale). Food Chem 2007; 102(3): 764-70.
[http://dx.doi.org/10.1016/j.foodchem.2006.06.023]
[13]
Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol 2005; 97(2): 227-30.
[http://dx.doi.org/10.1016/j.jep.2004.11.011] [PMID: 15707757]
[14]
Selvakumar M, Meenakshi RV, Sasidharan J, Sureshkumar P. Evaluation of the antioxidant and anti-arthritic potential of Zingiber officinale Rosc. by in vitro and in silico analysis. S Afr J Bot 2020; 130: 45-53.
[http://dx.doi.org/10.1016/j.sajb.2019.12.019]
[15]
Evans WC. Trease and Evans Pharmacognosy. 15th ed. Edinburgh: WB Saunders 2002; pp. 277-80.
[16]
Iyergar MA. Study of crude drugs. Hyderabad: BSP Book publisher 2019; p. 35.
[17]
Jiang H, Sólyom AM, Timmermann BN, Gang DR. Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2005; 19(20): 2957-64.
[http://dx.doi.org/10.1002/rcm.2140] [PMID: 16189817]
[18]
Hiroe K, Saiu MT, Nobuji N. Gingerdiol related compounds from the rhizomes of Zingiber officinale. Phytochemistry 1992; 31(5): 1783-6.
[http://dx.doi.org/10.1016/0031-9422(92)83147-Q]
[19]
Ma J, Jin X, Yang L, Liu ZL. Diarylheptanoids from the rhizomes of Zingiber officinale. Phytochemistry 2004; 65(8): 1137-43.
[http://dx.doi.org/10.1016/j.phytochem.2004.03.007] [PMID: 15110695]
[20]
Xiang L, Ziyang L, Hai Z, et al. Rapid LC-TOFMS separation and identification of diarylheptanoids and gingerol-related compounds in dried ginger. Chromatographia 2009; 69(5-6): 531-6. http://www.springerlink.com/content/9
[http://dx.doi.org/10.1365/s10337-008-0934-6]
[21]
Singh G, Kapoor IPS, Singh P, de Heluani CS, de Lampasona MP, Catalan CA. Chemistry, antioxidant and antimicrobial investigations on essential oil and oleoresins of Zingiber officinale. Food Chem Toxicol 2008; 46(10): 3295-302.
[http://dx.doi.org/10.1016/j.fct.2008.07.017] [PMID: 18706468]
[22]
Chareonkla A, Pohmakotr M, Reutrakul V, et al. A new diarylheptanoid from the rhizomes of Zingiber mekongense. Fitoterapia 2011; 82(4): 534-8.
[http://dx.doi.org/10.1016/j.fitote.2011.01.002] [PMID: 21238547]
[23]
Xiao W, Zhenjia Z, Xingfeng G, Jinpeng Y, Chengchao Z. Preparative separation of gingerols from Zingiber officinale by high-speed counter-current chromatography using stepwise elution. Food Chem 2011; 125(4): 1476-80.
[24]
Hori Y, Miura T, Hirai Y, et al. Pharmacognostic studies on ginger and related drugs--part 1: Five sulfonated compounds from Zingiberis rhizome (Shokyo). Phytochemistry 2003; 62(4): 613-7.
[http://dx.doi.org/10.1016/S0031-9422(02)00618-0] [PMID: 12560035]
[25]
Jolad SD, Lantz RC, Chen GJ, Bates RB, Timmermann BN. Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production. Phytochemistry 2005; 66(13): 1614-35.
[http://dx.doi.org/10.1016/j.phytochem.2005.05.007] [PMID: 15996695]
[26]
Chan FK, Graham DY. Review article: Prevention of non-steroidal anti-inflammatory drug gastrointestinal complications--review and recommendations based on risk assessment. Aliment Pharmacol Ther 2004; 19(10): 1051-61.
[http://dx.doi.org/10.1111/j.1365-2036.2004.01935.x] [PMID: 15142194]
[27]
Debjit B, Chiranjib C, Tripathi KK, Sampath K. Recent trends of treatment and medication peptic ulcerative disorder. Int J Pharm Tech Res 2010; 2(1): 970-80.
[28]
Wu TC. On the development of antifungal agents: Perspective of the U.S. Food and Drug Administration. Clin Infect Dis 1994; 19(Suppl. 1): S54-8.
[http://dx.doi.org/10.1093/clinids/19.Supplement_1.S54] [PMID: 7948572]
[29]
Walsh TJ, Gonzalez C, Lyman CA, Chanock SJ, Pizzo PA. Invasive fungal infections in children: Recent advances in diagnosis and treatment. Adv Pediatr Infect Dis 1996; 11: 187-290.
[PMID: 8718464]
[30]
Lazar JD, Wilner KD. Drug interactions with fluconazole. Rev Infect Dis 1990; 12(Suppl. 3): S327-33.
[http://dx.doi.org/10.1093/clinids/12.Supplement_3.S327] [PMID: 2330488]
[31]
Gearhart MO. Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity. Ann Pharmacother 1994; 28(10): 1177-81.
[http://dx.doi.org/10.1177/106002809402801009] [PMID: 7841574]
[32]
Goa KL, Barradell LB. Fluconazole. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients. Drugs 1995; 50(4): 658-90.
[http://dx.doi.org/10.2165/00003495-199550040-00007] [PMID: 8536553]
[33]
Gurgel LA, Sidrim JJC, Martins DT, Cechinel Filho V, Rao VS. In vitro antifungal activity of dragon’s blood from Croton urucurana against dermatophytes. J Ethnopharmacol 2005; 97(2): 409-12.
[http://dx.doi.org/10.1016/j.jep.2004.11.033] [PMID: 15707783]
[34]
Meyer SA, Kulkarni AP. HepatotoxicityIntroduction to Biochemical Toxicology. 3rd ed. New York: John Wiley and sons 2001; pp. 487-90.
[35]
Rao GM, Rao CV, Pushpangadan P, Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 2006; 103(3): 484-90.
[http://dx.doi.org/10.1016/j.jep.2005.08.073] [PMID: 16213120]
[36]
Kanchan G, Pradeep D, Pushpalata C, Joshi YM, Vilasrao K. A review on some nephroprotective medicinal plants. Int J Pharm Sci Res 2012; 3(8): 2451-4.
[37]
Giuffrè AM. Bergamot (Citrus bergamia, risso): The effects of cultivar and harvest date on functional properties of juice and cloudy juice. Antioxidants 2019; 8(7): 221.
[http://dx.doi.org/10.3390/antiox8070221] [PMID: 31336933]
[38]
Zapata MB, Chaparro DC, Rojano BA, Alzate AF, Restrepo LG, Maldonado ME. Effect of storage time on physicochemical, sensorial, and antioxidant characteristics, and composition of mango (cv. Azúcar) juice. Emir J Food Agric 2017; 29: 1.
[http://dx.doi.org/10.9755/ejfa.2016-09-1256]
[39]
Ak T, Gülçin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 2008; 174(1): 27-37.
[http://dx.doi.org/10.1016/j.cbi.2008.05.003] [PMID: 18547552]
[40]
Desai AG, Qazi GN, Ganju RK, et al. Medicinal plants and cancer chemoprevention. Curr Drug Metab 2008; 9(7): 581-91.
[http://dx.doi.org/10.2174/138920008785821657] [PMID: 18781909]
[41]
Xiao LC, Qun L, Yong BP, Lian WQ, Ping L. Steamed ginger (Zingiber officinale): Changed chemical profile and increased anticancer potential. Food Chem 2011; 129(4): 1785-92.
[http://dx.doi.org/10.1016/j.foodchem.2011.06.026]
[42]
Vadivelu N, Ramakrishnan S. HDL: Total cholesterol & HDL2:HDL3 cholesterol ratios in liver diseases. Indian J Med Res 1986; 83: 46-52.
[PMID: 3699868]
[43]
Seidel D, Wall A, Landman L, Staddler GA, Eds. Liver in Metabolic Diseases. Lancaster, England: MIP Press 1983; pp. 81-95.
[44]
Chander R, Singh C, Kapoor NK. Effect of chromic ethanol administration on serum lipoprotein lipid profile in rats. Biochem Life Sci Adv 1988; 7: 25-7.
[45]
Dwivedi Y, Rastogi R, Chander R, et al. Hepatoprotective activity of picroliv against carbon tetrachloride-induced liver damage in rats. Indian J Med Res 1990; 92: 195-200.
[PMID: 2401541]
[46]
Dudnik LB, Viksna LM. Maĭore A. Lipid peroxidation and its connection with the change in composition and antioxidant properties of lipids in comatogenic forms of acute viral hepatitis B. Vopr Med Khim 2000; 46(6): 597-609.
[PMID: 11234284]
[47]
Al-Nahain A, Jahan R, Rahmatullah M. Zingiber officinale: A potential plant against rheumatoid arthritis. Arthritis (Egypt) 2014; 2014: 159089.
[http://dx.doi.org/10.1155/2014/159089] [PMID: 24982806]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy