Generic placeholder image

Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Review Article

Herbal-Based Dressings in Wound Management

Author(s): Aniket Nikam, Asha Thomas*, Prabhanjan Giram, Dheeraj Nagore and Sohan Chitlange

Volume 19, Issue 4, 2023

Published on: 25 May, 2022

Article ID: e010422202937 Pages: 13

DOI: 10.2174/1573399818666220401105256

Price: $65

Abstract

Wound management is one of the major global challenges in recent times, and woundassociated infection has a significant impact on the healthcare economy worldwide. Wounds can be acute or chronic type, also diabetic, trauma, accidental, burn wounds and minor cuts, bruises, and rashes, etc. One of the primary treatment options available in these conditions are the use of suitable dressing materials to cover the wound and accelerate the healing process. Since ancient times, according to archaeological theories, medicinal plants and oils have been employed for the treatment of wounds. Today researchers across the globe are focusing their efforts on fabrication of novel dressing materials that can provide the most effective treatment, easy exchange of nutrients, and absorb exudate from the wounds. Very lately, various research groups are also concentrating on the design and development of herb-loaded wound dressings, as herbal preparations contain numerous phytoconstituents with a broad spectrum of pharmacological properties when compared to synthetic drugs and also due to the perceived notion that herbal products are generally safe, even when administered over prolonged periods. They contain numerous bioactive that can act on the various phases of the wound healing process, providing an ideal environment for the healing process. The present review discusses the numerous approaches that are employed for the preparation of dressing materials incorporated with plant-derived phytoconstituents/extracts. This review also provides an insight into the healing process and wound healing agents derived from medicinal plants and oils. The review can serve as a database for researchers working in this field and can help them to select the most appropriate dressing material for the effective delivery of herbal preparations in the management of wounds.

Keywords: Herbals, natural oils, bioactive phytoconstituents, wound dressings, dressing materials, wound healing.

[1]
Chua AWC, Khoo YC, Tan BK, Tan KC, Foo CL, Chong SJ. Skin tissue engineering advances in severe burns: Review and therapeutic applications. Burns Trauma 2016; 4(1): 3.
[http://dx.doi.org/10.1186/s41038-016-0027-y] [PMID: 27574673]
[2]
Sundaramurthi D, Krishnan UM, Sethuraman S. Electrospun nanofibers as scaffolds for skin tissue engineering. Polym Rev (Phila Pa) 2014; 54(2): 348-76.
[http://dx.doi.org/10.1080/15583724.2014.881374]
[3]
Boateng JS, Matthews KH, Stevens HN, Eccleston GM. Wound healing dressings and drug delivery systems: A review. J Pharm Sci 2008; 97(8): 2892-923.
[http://dx.doi.org/10.1002/jps.21210] [PMID: 17963217]
[4]
Master AM, Rodriguez ME, Kenney ME, Oleinick NL, Gupta AS. Delivery of the photosensitizer Pc 4 in PEG-PCL micelles for in vitro PDT studies. J Pharm Sci 2010; 99(5): 2386-98.
[http://dx.doi.org/10.1002/jps.22007] [PMID: 19967780]
[5]
Robson MC, Steed DL, Franz MG. Wound healing: Biologic features and approaches to maximize healing trajectories. Curr Probl Surg 2001; 38(2): 72-140.
[http://dx.doi.org/10.1067/msg.2001.111167] [PMID: 11452260]
[6]
Szycher M, Lee SJ. Modern wound dressings: A systematic approach to wound healing. J Biomater Appl 1992; 7(2): 142-213.
[http://dx.doi.org/10.1177/088532829200700204] [PMID: 1447701]
[7]
Suvarna K, Munira M. Wound healing process and wound care dressing: A detailed review. J Pharm Res 2013; 2(11): 6-12.
[8]
Enoch S, Harding K. Wound bed preparation: The science behind the removal of barriers to healing. Wounds 2003; 15(7): 213-29.
[9]
Ferreira MC, Tuma P Jr, Carvalho VF, Kamamoto F. Complex wounds. Clinics (São Paulo) 2006; 61(6): 571-8.
[http://dx.doi.org/10.1590/S1807-59322006000600014] [PMID: 17187095]
[10]
Hilton JR, Williams DT, Beuker B, Miller DR, Harding KG. Wound dressings in diabetic foot disease. Clin Infect Dis 2004; 39 (Suppl. 2): S100-3.
[http://dx.doi.org/10.1086/383270] [PMID: 15306987]
[11]
Dhivya S, Padma VV, Santhini E. Wound dressings - a review. Biomedicine (Taipei) 2015; 5(4): 22.
[http://dx.doi.org/10.7603/s40681-015-0022-9] [PMID: 26615539]
[12]
Rivera AE, Spencer JM. Clinical aspects of full-thickness wound healing. Clin Dermatol 2007; 25(1): 39-48.
[http://dx.doi.org/10.1016/j.clindermatol.2006.10.001] [PMID: 17276200]
[13]
Strecker-McGraw MK, Jones TR, Baer DG. Soft tissue wounds and principles of healing. Emerg Med Clin North Am 2007; 25(1): 1-22.
[http://dx.doi.org/10.1016/j.emc.2006.12.002] [PMID: 17400070]
[14]
Thomas A, Harding KG, Moore K. Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-α. Biomaterials 2000; 21(17): 1797-802.
[http://dx.doi.org/10.1016/S0142-9612(00)00072-7] [PMID: 10905462]
[15]
Mogoşanu GD, Grumezescu AM. Natural and synthetic polymers for wounds and burns dressing. Int J Pharm 2014; 463(2): 127-36.
[http://dx.doi.org/10.1016/j.ijpharm.2013.12.015] [PMID: 24368109]
[16]
Martin L, Wilson CG, Koosha F, et al. The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels. J Control Release 2002; 80(1-3): 87-100.
[http://dx.doi.org/10.1016/S0168-3659(02)00005-6] [PMID: 11943390]
[17]
Ichioka S, Harii K, Nakahara M, Sato Y. An experimental comparison of hydrocolloid and alginate dressings, and the effect of calcium ions on the behaviour of alginate gel. Scand J Plast Reconstr Surg Hand Surg 1998; 32(3): 311-6.
[http://dx.doi.org/10.1080/02844319850158660] [PMID: 9785436]
[18]
Tan ST, Winarto N, Dosan R, Aisyah PB. The benefits of occlusive dressings in wound healing. Open Dermatol J 2019; 13(1): 27-33.
[http://dx.doi.org/10.2174/1874372201913010027]
[19]
Ubbink DT, Vermeulen H, Goossens A, Kelner RB, Schreuder SM, Lubbers MJ. Occlusive vs. gauze dressings for local wound care in surgical patients: A randomized clinical trial. Arch Surg 2008; 143(10): 950-5.
[http://dx.doi.org/10.1001/archsurg.143.10.950] [PMID: 18936373]
[20]
Purna SK, Babu M. Collagen based dressings-a review. Burns 2000; 26(1): 54-62.
[http://dx.doi.org/10.1016/S0305-4179(99)00103-5] [PMID: 10630321]
[21]
Ramshaw JAM, Werkmeister JA, Glattauer V. Collagen-based biomaterials. Biotechnol Genet Eng Rev 1996; 13(1): 335-82.
[http://dx.doi.org/10.1080/02648725.1996.10647934] [PMID: 8948117]
[22]
Doillon CJ, Silver FH. Collagen-based wound dressing: Effects of hyaluronic acid and fibronectin on wound healing. Biomaterials 1986; 7(1): 3-8.
[http://dx.doi.org/10.1016/0142-9612(86)90080-3] [PMID: 3955155]
[23]
Ishihara M, Nakanishi K, Ono K, et al. Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process. Biomaterials 2002; 23(3): 833-40.
[http://dx.doi.org/10.1016/S0142-9612(01)00189-2] [PMID: 11771703]
[24]
Pilehvar-Soltanahmadi Y, Dadashpour M, Mohajeri A, Fattahi A, Sheervalilou R, Zarghami N. An overview on application of natural substances incorporated with electrospun nanofibrous scaffolds to development of innovative wound dressings. Mini Rev Med Chem 2018; 18(5): 414-27.
[http://dx.doi.org/10.2174/1389557517666170308112147] [PMID: 28271816]
[25]
Ghayempour S, Montazer M, Mahmoudi Rad M. Simultaneous encapsulation and stabilization of Aloe vera extract on cotton fabric for wound dressing application. RSC Advances 2016; 6(113): 111895-902.
[http://dx.doi.org/10.1039/C6RA22485G]
[26]
Agnes Mary S, Giri Dev VR. Electrospun herbal nanofibrous wound dressings for skin tissue engineering. J Textil Inst 2015; 106(8): 886-95.
[http://dx.doi.org/10.1080/00405000.2014.951247]
[27]
Ranjbar-Mohammadi M. Characteristics of aloe vera incorporated poly(ε-caprolactone)/gum tragacanth nanofibers as dressings for wound care. J Ind Text 2018; 47(7): 1464-77.
[http://dx.doi.org/10.1177/1528083717692595]
[28]
Oguntibeju OO. Medicinal plants and their effects on diabetic wound healing. Vet World 2019; 12(5): 653-63.
[http://dx.doi.org/10.14202/vetworld.2019.653-663] [PMID: 31327900]
[29]
Mabberley DJ. The plant-book: A portable dictionary of the vascular plants. Cambridge: Cambridge University Press 1997.
[30]
Nahrstedt A, Butterweck V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 1997; 30(S 2) (Suppl. 2): 129-34.
[http://dx.doi.org/10.1055/s-2007-979533] [PMID: 9342774]
[31]
Pourhojat F, Sohrabi M, Shariati S, Mahdavi H, Asadpour L. Evaluation of poly ε-caprolactone electrospun nanofibers loaded with Hypericum perforatum extract as a wound dressing. Res Chem Intermed 2017; 43(1): 297-320.
[http://dx.doi.org/10.1007/s11164-016-2623-7]
[32]
Güneş S, Tıhmınlıoğlu F. Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material. Int J Biol Macromol 2017; 102: 933-43.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.04.080] [PMID: 28450246]
[33]
Minden-Birkenmaier BA, Bowlin GL. Honey-based templates in wound healing and tissue engineering. Bioengineering (Basel) 2018; 5(2): E46.
[http://dx.doi.org/10.3390/bioengineering5020046] [PMID: 29903998]
[34]
Scagnelli AM. Therapeutic review: Manuka honey. J Exot Pet Med 2016; 25(2): 168-71.
[http://dx.doi.org/10.1053/j.jepm.2016.03.007]
[35]
Lusby PE, Coombes AL, Wilkinson JM. Bactericidal activity of different honeys against pathogenic bacteria. Arch Med Res 2005; 36(5): 464-7.
[http://dx.doi.org/10.1016/j.arcmed.2005.03.038] [PMID: 16099322]
[36]
Ingle R, Levin J, Polinder K. Wound healing with honey--a randomised controlled trial. S Afr Med J 2006; 96(9): 831-5.
[PMID: 17068655]
[37]
Henriques A, Jackson S, Cooper R, Burton N. Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother 2006; 58(4): 773-7.
[http://dx.doi.org/10.1093/jac/dkl336] [PMID: 16963460]
[38]
Visavadia BG, Honeysett J, Danford MH. Manuka honey dressing: An effective treatment for chronic wound infections. Br J Oral Maxillofac Surg 2008; 46(1): 55-6.
[http://dx.doi.org/10.1016/j.bjoms.2006.09.013] [PMID: 17113690]
[39]
Packer JM, Irish J, Herbert BR, et al. Specific non-peroxide antibacterial effect of Manuka honey on the Staphylococcus aureus proteome. Int J Antimicrob Agents 2012; 40(1): 43-50.
[http://dx.doi.org/10.1016/j.ijantimicag.2012.03.012] [PMID: 22580031]
[40]
Blair SE, Cokcetin NN, Harry EJ, Carter DA. The unusual antibacterial activity of medical-grade Leptospermum honey: Antibacterial spectrum, resistance and transcriptome analysis. Eur J Clin Microbiol Infect Dis 2009; 28(10): 1199-208.
[http://dx.doi.org/10.1007/s10096-009-0763-z] [PMID: 19513768]
[41]
Willix DJ, Molan PC, Harfoot CG. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of Manuka honey and other honey. J Appl Bacteriol 1992; 73(5): 388-94.
[http://dx.doi.org/10.1111/j.1365-2672.1992.tb04993.x] [PMID: 1447054]
[42]
Yang X, Fan L, Ma L, et al. Green electrospun Manuka honey/silk fibroin fibrous matrices as potential wound dressing. Mater Des 2017; 119: 76-84.
[http://dx.doi.org/10.1016/j.matdes.2017.01.023]
[43]
Saraswathy N, Rohit R, Shanmugam K, Charanya Sozheeswari S, Ramalingam P. A preliminary investigation of turmeric-agar composite film as bioactive wound dressing material on excision wound in rat model. Indian J Nat Prod Resour 2012; 3(2): 237-41.
[44]
Gopinath D, Ahmed MR, Gomathi K, Chitra K, Sehgal PK, Jayakumar R. Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 2004; 25(10): 1911-7.
[http://dx.doi.org/10.1016/S0142-9612(03)00625-2] [PMID: 14738855]
[45]
Suwantong O, Opanasopit P, Ruktanonchai U, Supaphol P. Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer 2007; 48: 7546-57.
[http://dx.doi.org/10.1016/j.polymer.2007.11.019]
[46]
Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 2008; 46(2): 409-20.
[http://dx.doi.org/10.1016/j.fct.2007.09.085] [PMID: 17950516]
[47]
Afzal M, Al-Hadidi D, Menon M, Pesek J, Dhami MSI. Ginger: An ethnomedical, chemical and pharmacological review. Drug Metabol Drug Interact 2001; 18(3-4): 159-90.
[http://dx.doi.org/10.1515/DMDI.2001.18.3-4.159] [PMID: 11791883]
[48]
Pourali P, Yahyaei B. The healing property of a bioactive wound dressing prepared by the combination of bacterial cellulose (BC) and Zingiber officinale root aqueous extract in rats. 3 Biotech 2019; 9(2)
[http://dx.doi.org/10.1007/s13205-019-1588-9]
[49]
Chantarodsakun T, Vongsetskul T, Jangpatarapongsa K, et al. [6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release. Polym Bull 2014; 71(12): 3163-76.
[http://dx.doi.org/10.1007/s00289-014-1243-x]
[50]
Okuma CH, Andrade TAM, Caetano GF, et al. Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing. Eur J Pharm Sci 2015; 71: 62-72.
[http://dx.doi.org/10.1016/j.ejps.2015.01.016] [PMID: 25684193]
[51]
Givol O, Kornhaber R, Visentin D, Cleary M, Haik J, Harats M. A systematic review of Calendula officinalis extract for wound healing. Wound Repair Regen 2019; 27(5): 548-61.
[http://dx.doi.org/10.1111/wrr.12737] [PMID: 31145533]
[52]
Nicolaus C, Junghanns S, Hartmann A, Murillo R, Ganzera M, Merfort I. In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. J Ethnopharmacol 2017; 196(196): 94-103.
[http://dx.doi.org/10.1016/j.jep.2016.12.006] [PMID: 27956358]
[53]
Chandran V, Muthuraman P. A preliminary in vitro study on the bovine collagen film incorporated with Azadirachta indica plant extract as a potential wound dressing material. Int J Pharm Tech Res 2015; 8(6): 248-57.
[54]
Viji Chandran S, Amritha TS, Rajalekshmi G, Sujatha S PM. Collagen – Azadirachta indica (Neem) leaves extract hybrid film as a novel wound dressing: In vitro studies. Int J Pharm Sci Rev Res 2015; 32(2): 193-9.
[55]
Jin G, Prabhakaran MP, Kai D, Annamalai SK, Arunachalam KD, Ramakrishna S. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials 2013; 34(3): 724-34.
[http://dx.doi.org/10.1016/j.biomaterials.2012.10.026] [PMID: 23111334]
[56]
Mahboubi M. Industrial Crops & Products Elaeagnus angustifolia and its therapeutic applications in osteoarthritis. Ind Crops Prod 2017; 2018(121): 36-45.
[http://dx.doi.org/10.1016/j.indcrop.2018.04.051]
[57]
Hamidpour R, Hamidpour S, Hamidpour M, et al. Russian olive (Elaeagnus angustifolia L.): From a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-mutagenic and analgesic agent. J Tradit Complement Med 2016; 7(1): 24-9.
[http://dx.doi.org/10.1016/j.jtcme.2015.09.004] [PMID: 28053884]
[58]
Farzaei MH, Bahramsoltani R, Abbasabadi Z, Rahimi R. A comprehensive review on phytochemical and pharmacological aspects of Elaeagnus angustifolia L. J Pharm Pharmacol 2015; 67(11): 1467-80.
[http://dx.doi.org/10.1111/jphp.12442] [PMID: 26076872]
[59]
Nourmohammadi J, Hadidi M, Nazarpak MH, Mansouri M, Hasannasab M. Physicochemical and antibacterial characterization of nanofibrous wound dressing from silk fibroin-polyvinyl alcohol- Elaeagnus angustifolia extract. Fibers Polym 2020; 21(3): 456-64.
[http://dx.doi.org/10.1007/s12221-020-9428-4]
[60]
Lin S, Chen M, Jiang H, et al. Green electrospun grape seed extract-loaded silk fibroin nanofibrous mats with excellent cytocompatibility and antioxidant effect. Colloids Surf B Biointerfaces 2016; 139: 156-63.
[http://dx.doi.org/10.1016/j.colsurfb.2015.12.001] [PMID: 26707696]
[61]
Electrospinning MX. Electrospinning of crude plant extracts for antibacterial and wound healing applications: A review. SM J Biomed Eng 2018; 4(1): 1024.
[62]
Muhammad AA, Arulselvan P, Cheah PS, Abas F, Fakurazi S. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug Des Devel Ther 2016; 10: 1715-30.
[http://dx.doi.org/10.2147/DDDT.S96968] [PMID: 27307703]
[63]
Gupta R, Mathur M, Bajaj VK, et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes 2012; 4(2): 164-71.
[http://dx.doi.org/10.1111/j.1753-0407.2011.00173.x] [PMID: 22103446]
[64]
Muhammad AA, Pauzi NAS, Arulselvan P, Abas F, Fakurazi S. In vitro wound healing potential and identification of bioactive compounds from Moringa oleifera Lam. Biomed Res Int 2013; 2013
[65]
Rathi B, Patil PA, Baheti AM. Evaluation of aqueous extract of pulp and seeds of Moringa oleifera for wound healing in albino rats. J Nat Rem 2004; 4(2): 145-9.
[66]
Chin CY, Jalil J, Ng PY, Ng SF. Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound heal-ing application. J Ethnopharmacol 2018; 212(212): 188-99.
[http://dx.doi.org/10.1016/j.jep.2017.10.016] [PMID: 29080829]
[67]
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999; 86(6): 985-90.
[http://dx.doi.org/10.1046/j.1365-2672.1999.00780.x] [PMID: 10438227]
[68]
Marino M, Bersani C, Comi G. Antimicrobial activity of the essential oils of Thymus vulgaris L. measured using a bioimpedometric method. J Food Prot 1999; 62(9): 1017-23.
[http://dx.doi.org/10.4315/0362-028X-62.9.1017] [PMID: 10492476]
[69]
Sa M. Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chem 2005; 91(4): 621-32.
[http://dx.doi.org/10.1016/j.foodchem.2004.06.031]
[70]
Burt SA. Antibacterial activity of essential oils: Potential applications in food. Int J Food Microbiol 2004; Vol. 94: 223-53.
[71]
Braga PC, Dal Sasso M, Culici M, Bianchi T, Bordoni L, Marabini L. Anti-inflammatory activity of thymol: Inhibitory effect on the release of human neutrophil elastase. Pharmacology 2006; 77(3): 130-6.
[http://dx.doi.org/10.1159/000093790] [PMID: 16763380]
[72]
Rojas-Graü MA, Avena-Bustillos RJ, Olsen C, et al. Effects of plant essential oils and oil compounds on mechanical, barrier and antimicrobial properties of alginate-apple puree edible films. J Food Eng 2007; 81(3): 634-41.
[http://dx.doi.org/10.1016/j.jfoodeng.2007.01.007]
[73]
Altiok D, Altiok E, Tihminlioglu F. Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications. J Mater Sci Mater Med 2010; 21(7): 2227-36.
[http://dx.doi.org/10.1007/s10856-010-4065-x] [PMID: 20372985]
[74]
Evandri MG, Battinelli L, Daniele C, Mastrangelo S, Bolle P, Mazzanti G. The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay. Food Chem Toxicol 2005; 43(9): 1381-7.
[http://dx.doi.org/10.1016/j.fct.2005.03.013] [PMID: 15907354]
[75]
Mayaud L, Carricajo A, Zhiri A, Aubert G. Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics. Lett Appl Microbiol 2008; 47: 167-73.
[http://dx.doi.org/10.1111/j.1472-765X.2008.02406.x]
[76]
Sofi HS, Akram T, Tamboli AH, Majeed A, Shabir N, Sheikh FA. Novel lavender oil and silver nanoparticles simultaneously loaded onto polyurethane nanofibers for wound-healing applications. Int J Pharm 2019; 569: 118590.
[http://dx.doi.org/10.1016/j.ijpharm.2019.118590] [PMID: 31381988]
[77]
Mori HM, Kawanami H, Kawahata H, Aoki M. Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model. BMC Complement Altern Med 2016; 16(1): 144.
[http://dx.doi.org/10.1186/s12906-016-1128-7] [PMID: 27229681]
[78]
Hui L, He L, Huan L, Xiaolan L, Aiguo Z. Chemical composition of lavender essential oil and its antioxidant activity and inhibition against rhinitis-related bacteria. Afr J Microbiol Res 2010; 4(4): 309-13.
[79]
Alam P, Ansari MJ, Anwer MK, Raish M, Kamal YKT, Shakeel F. Wound healing effects of nanoemulsion containing clove essential oil. Artif Cells Nanomed Biotechnol 2017; 45(3): 591-7.
[http://dx.doi.org/10.3109/21691401.2016.1163716] [PMID: 28211300]
[80]
Unalan I, Endlein SJ, Slavik B, et al. Evaluation of electrospun poly(ε-caprolactone)/gelatin nanofiber mats containing clove essential oil for antibacterial wound dressing. Pharmaceutics 2019; 11(11): E570.
[http://dx.doi.org/10.3390/pharmaceutics11110570] [PMID: 31683863]
[81]
Pereira Dos Santos E, Nicácio PHM, Coêlho Barbosa F, et al. Chitosan/essential oils formulations for potential use as wound dressing: Physical and antimicrobial properties. Materials (Basel) 2019; 12(14): 2223.
[http://dx.doi.org/10.3390/ma12142223] [PMID: 31295876]
[82]
Saxena M. Herbal formulation for wound healing. US0178367A1, 2007.
[83]
Pillay V. Wound dressing. US10080816B2, 2018.
[84]
Wayman R. Wound dressing. US4226232A, 1980.
[85]
David A. Court transparent hydrogel wound dressing. US4226232A, 2009.
[86]
Patankar SB. Herbal composition for the treatment of wound healing, regenerative medicine. US8709509B2, 2014.
[87]
Burrell RE. Anti-microbial coatings having indicator properties and wound dressings. US6333093B1, 2001.
[88]
Hoon R. Microbial cellulose wound dressing for treating chronic wounds. US20050019380A1, 2005.
[89]
Roy P. Use of honey in dressing. US7714183B2, 2010.
[90]
Bowler P. Silver-containing wound dressing for continuous release of antimicrobial. US20070286895A1, 2007.
[91]
Ma R-H, Yu Y-H. Nano-silver wound dressing. US20150119358A1, 2015.
[92]
Mo XH, Wang XD, Wu ZJ. Chitosan wound dressing and its method of manufacturing. US20150135644A1, 2015.
[93]
Sahoo SK, Chandana M. Process for preparing curcumin encapsulated chitosan alginate sponge useful for wound healing. US2010171215A1, 2013.
[94]
Maver T, Maver U, Stana Kleinschek K, Smrke DM, Kreft S. A review of herbal medicines in wound healing. Int J Dermatol 2015; 54(7): 740-51.
[http://dx.doi.org/10.1111/ijd.12766] [PMID: 25808157]
[95]
Ahuja A, Gupta J, Gupta R. Miracles of herbal phytomedicines in treatment of skin disorders: Natural healthcare perspective. Infect Disord Drug Targets 2021; 21(3): 328-38.
[http://dx.doi.org/10.2174/1871526520666200622142710]
[96]
Zhao W, Zhang X, Zhang R, Zhang K, Li Y, Xu FJ. Self-assembled herbal medicine encapsulated by an oxidation-sensitive supramolecular hydrogel for chronic wound treatment. ACS Appl Mater Interfaces 2020; 12(51): 56898-907.
[http://dx.doi.org/10.1021/acsami.0c19492] [PMID: 33296174]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy