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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

State of the Art in Industrial Application of Amino-1,2,4-Triazoles

Author(s): Valerii Nazarov, Denis Miroshnichenko, Oleksandra Ivakh, Serhiy Pyshyev* and Bohdan Korchak

Volume 20, Issue 4, 2023

Published on: 19 August, 2022

Page: [394 - 402] Pages: 9

DOI: 10.2174/1570193X19666220331155015

Price: $65

Abstract

The review summarizes information regarding the industrial use of 3- and 4-amino-1,2,4- triazoles, the basic raw material for the industry of fine organic synthesis. A description of the existing production methods for the synthesis of 3- and 4-amino-1,2,4-triazoles under laboratory conditions is provided. Three main areas of use of these amines and their derivatives have been identified: Agriculture, medicine, high-energy substances and gas-generating composition. It has been shown that one of the earliest areas of widespread use of 3- and 4-amino-1,2,4-triazoles is the production of plant protection products. The mass production of various insecticides, fungicides, plant growth regulators, retardants, and nitrification inhibitors of nitrogen fertilizers has been organized. The use of these amines in medicine consists of the production of known drugs, such as furazonal, thiotriazoline and cardiotril, which have hepatoprotective, antioxidant, and anti-ischemic activity. The industrial processing of 3- and 4-amino-1,2,4-triazoles into explosives, solid propellants and gas-generating compositions is a third well-known field of application. The high reactivity of amines and the variety of areas for their use are explained. A significant emphasis is given to the analysis of aminotriazoles. This is the production of new types of salts and electrically conductive ionic liquids, corrosion inhibitors of non-ferrous metals, and catalysts for curing epoxy resins. The results of recent studies are discussed, and the prospects for using 3- and 4-amino-1,2,4-triazoles as raw materials for the production of new reagents in analytical chemistry, proton-exchange membranes, and new condensed nitrogen-containing heterocycles are explained.

Keywords: amino-1, 2, 4-triazoles, raw materials for synthesis, pesticides, medicines, high energy products, industrial processing

Graphical Abstract

[1]
Yu, Y.; Ostresh, J.M.; Houghten, R.A. Solid-phase synthesis of 3-amino-1,2,4-triazoles. Tetrahedron Lett., 2003, 44(42), 7841-7843.
[http://dx.doi.org/10.1016/j.tetlet.2003.08.074]
[2]
Naito, Y.; Akahoshi, F.; Takeda, S.; Okada, T.; Kajii, M.; Nishimura, H.; Sugiura, M.; Fukaya, C.; Kagitani, Y. Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia. J. Med. Chem., 1996, 39(15), 3019-3029.
[http://dx.doi.org/10.1021/jm9507993] [PMID: 8709136]
[3]
Chernyshev, V.M.; Tarasova, E.V.; Chernysheva, A.V. Single-reaction synthesis of 3-substituted-5-amino-1,2,4-triazoles based on the reaction of aminoguanidine with carboxylic acids. News of Higher Educational Institutions, 2013, 3, 66-70.
[4]
Guennoun, L. El jastimi, J.; Guédira, F.; Marakchi, K.; Kabbaj, O.K.; El Hajji, A.; Zaydoun, S. Molecular geometry and vibrational studies of 3,5-diamino-1,2,4-triazole using quantum chemical calculations and FT-IR and FT-Raman spectroscopies. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2011, 78(1), 347-353.
[http://dx.doi.org/10.1016/j.saa.2010.10.019] [PMID: 21112810]
[5]
Barmin, M.I.; Melnikov, V.V. New amino-1,2,4-triazolyl and tetrazolyl alkanes; SPGUTD: St. Petersburg, 2002, p. 240.
[6]
Castanedo, G.M.; Seng, P.S.; Blaquiere, N.; Trapp, S.; Staben, S.T. Rapid synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from carboxylic acids, amidines and hydrazines. J. Org. Chem., 2011, 76, 1177-1179.
[http://dx.doi.org/10.1021/jo1023393] [PMID: 21235245]
[7]
Chai, B.; Qian, X.; Cao, S.; Liu, H.; Song, G. Synthesis and insecticidal activity of 1,2,4- triazole derivatives. ARKIVOC, 2003, 2(2), 141-145.
[http://dx.doi.org/10.3998/ark.5550190.0004.216]
[8]
Wang, H.Y.; Zhao, P.S.; Li, R.Q.; Zhou, S.M. Synthesis, crystal structure and quantum chemical study on 3-phenylamino-4-phenyl-1,2,4-triazole-5-thione. Molecules, 2009, 14(2), 608-620.
[http://dx.doi.org/10.3390/molecules14020608] [PMID: 19214151]
[9]
Rubtsov, M.V.; Baichikov, A.G. Synthetic Chemical and Pharmaceutical Preparations (reference book); Meditsina: Moscow, 1971.
[10]
Liu, L.L.; Yang, G. Synthesis of 3,5-di-(4-pyridyl)-1H-1,2,4-triazole. Molbank, 2008, 63(1), M563.
[http://dx.doi.org/10.3390/M563]
[11]
Kumar, S.P.; Mishra, D.; Ghosh, G.; Panda, C.S. Synthesis and Schiff and mannich bases of isatin derivatives with 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones. Pharma Chem., 2010, 2(3), 209-216.
[http://dx.doi.org/10.26717/BJSTR.2020.30.004991]
[12]
Gilchrist, T.L. Heterocyclic Chemistry; John Wiley & Sons: New York, 1996.
[13]
Joule, J.A.; Smith, G.F. Heterocyclic Chemistry; Van Nostrand Reinhold Company: London, 1972.
[14]
Voronkov, M.G.; Kashyk, T.V.; Makarsky, V.V. Basicity 5(3)-substituted-3(5)-amino-1,2,4-triazole and their protonation. Dokl., 1976, 227(5), 1116-1119.
[15]
Jawad, K.S.; Yusra, H.A. Chemistry of 1,2,4-triazole: A review article. Int. J. Sci. Res., 2016, 5(3), 1411-1423.
[http://dx.doi.org/10.4103/1735-5362.253360]
[16]
Fiedler, Zh.N.; Shibanova, E.F.; Makerov, P.V.; Kalikhman, I.D. Acyl derivatives of 3-amino-1,2,4-triazole. KHGS, 1980, 10, 1414-1419.
[17]
Makarsky, V.V.; Zubkov, V.A.; Lopyrev, V.A.; Voronkov, M.G. Quantum-chemical analysis of the tautomerism of 1,2,4-triazole and its amino- and diamine derivatives. Chem. Heterocycl. Compd., 1977, 13(4), 436-440.
[18]
Zhou, C-H.; Wang, Y. Recent researches in triazole compounds as medicinal drugs. Curr. Med. Chem., 2012, 19(2), 239-280.
[http://dx.doi.org/10.2174/092986712803414213] [PMID: 22320301]
[19]
Kaplan, G.I.; Kukalenko, S.S. Triazoles and their Pesticide Activity; Niitekhim: Moscow, 1983.
[20]
Kumar, S.S.; Kavitha, H.P. Synthesis and biological applications of triazole derivatives – A review. Mini Rev. Org. Chem., 2013, 10, 40-65.
[http://dx.doi.org/10.2174/1570193X11310010004]
[21]
Shamshurin, A.A.; Krimer, M.Z. Physico-Chemical Properties of Pesticides. Reference book; Chemistry: Moscow, 1976.
[22]
Melnikov, N.N. Substitution of 1,2,4-triazoles. Systemic fungicides Moscow, Mir, 1975.
[23]
Cao, K.; Yang, X. Fungicides of 1,2,4-triazole compaunds. Spec. Petrochem., 2007, 24(6), 82-86.
[http://dx.doi.org/10.3390/ph14030224]
[24]
Barmin, M.I.; Gromova, S.A.; Lebedintseva, O.V.; Tyuterev, S.L.; Mel’nikov, V.V. Fungicide activity of new azole derivatives. Russ. J. Appl. Chem., 1995, 68(8), 1163-1167.
[25]
Chukalenko, S.S.; Volodkovich, S.D. Systemic Fungicides and Seed Treatments; Niitekhim: Moscow, 1981.
[26]
Singh, S.; Kumar, V.; Dhanjal, D.S.; Singh, J. Herbicides and Plant Growth Regulators: Current Developments and Future Challenges. In: Natural Bioactive Products in Sustainable Agriculture; Singh, J.; Yadav, A., Eds.;
[27]
Umirov, F.E.; Khudoiberdiev, F.I.; Tukhtaev, S.T. Preparation of defoliants based on 4-amino-1,2,4-triazole with sodium and magnesium chlorates. Bulletin of Science and Education, 2018, 3(39), 14-16.
[28]
Zubkova, N.F.; Gruzinskaya, N.A. Application and features of the action of defoliants and desikants. Agrokhimia, 1991, 8, 126-143.
[29]
Protsenko, A.N.; Shakirova, O.G. Study of the condensation product of 4-amino-1,2,4-triazole and formaldehyde, preparation of a copper (II) complex based on it and comparison of their biological activity. Molecules, 2015, 5, 38-42.
[30]
Prusakova, L.D.; Chizhova, S.I. Application of triazole derivatives in crop production. Agrokhimia, 1998, 10, 37-44.
[31]
Belei, D.; Bicu, E.; Birsa, L. 1,3-Dipolar cycloaddition reactions of N-acetylazido-2-chlorophenothiazine. Acta Chem. Ias, 2009, 17, 197-207.
[32]
Kumeyko, Y.V.; Parashchenko, V.N.; Kremzin, N.M. Influence of the nitrification inhibitor on the efficiency of nitrogen fertilizer and preservation of soil fertility in the development of rice. Dostyzhenye nauki i tekhniki APC, 2015, 29(12), 85-87.
[33]
Georgievsky, G.V. Biological activity of 1,2,4-triazole derivatives. Farmakom, 2006, 3, 27-31.
[34]
Georgievsky, G.V. Development of a complex of physical and chemical methods that ensure the creation and quality control of original domestic preparations produced by 1,2,4-triazole. Zaporozhye Med. J., 2011, 13(1), 58-69.
[35]
Georgievsky, G.V. Targeted search for new pharmacologically active drugs among the production of triazoles. Farmakom, 2007, 2, 60-66.
[36]
Kucherenko, L.I.; Georgievsky, G.V.; Shapovalova, L.I. Development of methods of standardization of a new drug – cardiotril. Farmakom, 2008, 3, 55-60.
[37]
Arul, K. Synthesis and in vitro Anticancer evaluation of some novel 1,2,4-triazole derivatives. Experiment, 2014, 21(1), 1439-1452.
[http://dx.doi.org/10.15421/021830]
[38]
Mobinikhaledi, A.; Foroughifar, N.; Khanpour, M.; Ebrahimi, S. Synthesis of some novel schiff bases containing 1,2,4-triazole ring. Eur. J. Chem., 2010, 1(1), 33-36.
[http://dx.doi.org/10.5155/eurjchem.1.1.33-36.5]
[39]
Sahoo, S. Synthesis and biological activity of certain mahnich bases derivatives from 1,2,4-triazoles. Iranian J. Pharma. Sci, 2013, 9(4), 51-60.
[http://dx.doi.org/10.5155/eurjchem.11.2.113-119.1968]
[40]
Holam, S.C.; Straub, B.F. Synthesis of N-substituted 1,2,4-Triazole: A review. Org. Prep. Proced. Int., 2011, 43(4), 319-347.
[http://dx.doi.org/10.1080/00304948.2011.593999]
[41]
Fan, Y.; Xia, Y.; Tang, J.; Rocchi, P.; Qu, F.; Iovanna, J.; Peng, L. Ligand-mediated highly effective and selective C-N coupling for synthesizing bioactive N-aryltriazole acyclonucleosides. Org. Lett., 2010, 12(24), 5712-5715.
[http://dx.doi.org/10.1021/ol102537p] [PMID: 21086980]
[42]
Hu, G.Q.; Wang, H.Y.; Wu, X.Q.; Wang, X. Synthesis and antitumor activity of pyridy s-triazole Schiff-bases containing functional side-chain of poly (thio-oxo) ether. Chung Kuo Yao Hsueh Tsa Chih, 2009, 44, 1511-1514.
[http://dx.doi.org/10.1080/14786419.2019.1645660]
[43]
Bekircan, O.; Kahveci, B.; Kucuk, M. Synthesis and anticancer evaluation of some new unsymmetrical 3,5-diaryl-4H-1,2,4-triazole derivatives. Turk. J. Chem., 2006, 30, 29-40.
[44]
Goyal, P.K.; Bhandan, A.; Rana, A.C.; Jain, C.B. Synthesis of some 3-substituted-4H-1,2,4-triazole derivatives with potent anti-inflammatory activity. As. J. Pharm. Clin. Res, 2010, 3(3), 244-246.
[45]
Kshirsagar, A.; Toraskar, M.P.; Kulkami, V.M.; Kadam, V. Microwave-assisted synthesis of potential anti-infective and anticonvulsant thiosemicarbazones. Int. J. Chemtech Res., 2009, 1, 696-701.
[46]
Abdel-Megeed, A.M.; Abdel-Rahman, H.M.; Alkaramany, G.E.; El-Gendy, M.A. Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. Eur. J. Med. Chem., 2009, 44(1), 117-123.
[http://dx.doi.org/10.1016/j.ejmech.2008.03.017] [PMID: 18455273]
[47]
Singh, R.J.; Singh, D.K. Synthesis, characterization and biological activity of some 1,2,4-triazole derivatives. J. Chem., 2009, 6(3), 796-800.
[48]
Gumrukcuoglu, N.; Serdar, M.; Celik, E.; Sevim, A.; Demirbas, N. Sinthesis and antimicrobial activities of some new 1,2,4-triazole derivatives. Turk. J. Chem., 2007, 31, 335-348.
[49]
Mavrova, A.T.; Wesselinova, D.; Tsenov, Y.A.; Denkova, P. Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells. Eur. J. Med. Chem., 2009, 44(1), 63-69.
[http://dx.doi.org/10.1016/j.ejmech.2008.03.006] [PMID: 18439727]
[50]
Gobis, K.; Foks, H.; Zwolska, Z. Augustynowicz-Kopeć, E. Synthesis and tuberculostatic activity of novel 1,2,4-triazoles obtained from heterocyclic carbohydrazides. Heterocycles, 2010, 81(4), 917-934.
[http://dx.doi.org/10.3987/COM-09-11888]
[51]
Murti, Y.; Agnihotri, R.; Pathak, D. Synthesis characterization and pharmacological screening of some substituted 1,2,3 & 1,2,4-triazoles. American J. Chem, 2011, 1(2), 42-46.
[http://dx.doi.org/10.5923/j.chemistry.20110102.09]
[52]
Maddila, S.; Jonnalagadda, S.B. New class of triazole derivatives and their antimicrobial activity. Lett. Drug Des. Discov., 2012, 9(7), 687-693.
[http://dx.doi.org/10.2174/157018012801319526]
[53]
Pyatakov, D.A.; Chernyshev, V.M. Novocherkassk, High-Energy Materials Based on Nitrogen-Containing Heterocycles, YURSPU (NPI).
[54]
Pozharsky, A.F. Theoretical Foundations of the Chemistry of Heterocycles; Khimiya: Moscow, 1985.
[55]
Zinoviev, V.M.; Kutsenko, G.V.; Ermilov, A.S. High-energy fillers of solid rocket fuels and other high-energy condensed systems, 2011.
[56]
Lee, K.Y.; Storm, C.B.; Hiskey, M.A.; Coburn, M.D. An improved synthesis of 5-amino-3-nitro-1H-1,2,4-triazole (ANTA), a useful intermediate for the preparation of insensitive high explosives. J. Energ. Mater., 1991, 9(5), 415-428.
[http://dx.doi.org/10.1080/07370659108019382]
[57]
Pevsner, M.S. Derivatives of 1,2,4-triazole-high-energy compounds. Ross. Chem. Zhurnal, 1997, 41(2), 73-83.
[58]
Mirzaei, Y.R.; Twamley, B.; Shreeve, J.M. Syntheses of 1-alkyl-1,2,4-triazoles and the formation of quaternary 1-alkyl-4-polyfluoroalkyl-1,2,4-triazolium salts leading to ionic liquids. J. Org. Chem., 2002, 67(26), 9340-9345.
[http://dx.doi.org/10.1021/jo026350g] [PMID: 12492336]
[59]
Voronkov, M.G.; Shagun, L.G.; Dorofeev, I.A. Unusual interaction of 3-amino-1,2,4-triazole with 1,3-diiodpropane-2-one. Izvestiya RAN. Chemical Series, 2013, 11, 2554-2556.
[60]
Gruzdev, M.S.; Kolker, A.M.; Aslanov, L.A. Ionic liquids: Theory and Practice; Ivanovo Publishing House: Ivanovo, 2019.
[61]
Lei, R.; Gao, L.; Jin, R.; Qiu, X. Sulfonated polyimides containing 1,2,4-triazole groups for proton exchange membranes. Chin. J. Polym. Sci., 2014, 32(7), 941-952.
[http://dx.doi.org/10.1007/s10118-014-1460-7]
[62]
Saito, J.; Miyatake, K.; Watanabe, M. Synthesis and properties of polyimide ionomers containing 1H-1,2,4-triazole groups. Macromolecules, 2008, 41(7), 2415-2420.
[http://dx.doi.org/10.1021/ma7028055]
[63]
Subbaraman, R.; Ghassemi, H.; Zawodzinski, T., Jr Triazole and triazole derivatives as proton transport facilitators in polymer electrolyte membrane fuel cells. Solid State Ion., 2009, 180(20-22), 20-22, 1143-1150.
[http://dx.doi.org/10.1016/j.ssi.2009.05.018]
[64]
Potrekar, R.A.; Kulkarni, M.P.; Kulkarni, R.A.; Vernekar, S.P. Polybenzimidazoles tethered with N-phenyl 1,2,4-triazole units as polymer electrolytes for fuel cells. J. Polym. Sci. A Polym. Chem., 2009, 47(9), 2289-2303.
[http://dx.doi.org/10.1002/pola.23310]
[65]
Nenitsescu, K.D. Org. Chem; Publishing House of Foreign Literature: Moscow, 1963.
[66]
Blumenthal, G.; Engels, C.; Fitz, I.; Haberzettl, V. Inorganicos; Mir: Moscow, 1984.
[67]
Kharitonov, Y. Analytical chemistry. In: General theoretical foundations: Qualitative analysis. Textbook for Universities; Higher School: Moscow, 2001.
[68]
Liu, K.; Shi, W.; Cheng, P. The coordination chemistry of Zn(II), Cd(II) and Hg(II) complexes with 1,2,4-triazole derivatives. Dalton Trans., 2011, 40(34), 8475-8490.
[http://dx.doi.org/10.1039/c0dt01578d] [PMID: 21629962]
[69]
Kuznetsov, Y.I.; Kazansky, L.P. Physico-chemical aspects of metal protection by corrosion inhibitors of the azoles class. Russ. Chem. Rev., 2008, 77(3), 219.
[70]
Garcia-Ochoa, E.; Genesca, J. Understanding the inhibiting properties of 3-amino-1,2,4-triazole from fractal analysis. Surf. Coat. Tech., 2004, 184(2), 322-330.
[http://dx.doi.org/10.1016/j.surfcoat.2003.11.019]
[71]
Sripriyal, S.; Subha, C. The inhibition chemistry of 3-amino- 5-phenyl 1,2,4-triazole for aluminium in hydrochloric acid solution. IOSR-. J. Appl. Chem., 2013, 6(2), 25-29.
[http://dx.doi.org/10.9790/5736-0622529]
[72]
Qafsaoui, W.; Takenouti, H. Corrosion protection of 2024-T3 aluminium alloy by electro-polymerized 3-amino-1,2,4-triazole in sulphate solution containing chloride. Corros. Sci., 2010, 52(11), 3667-3676.
[http://dx.doi.org/10.1016/j.corsci.2010.07.014]
[73]
Ramesh, S.; Rajeswari, S. Corrosion inhibition of mild steel in neutral aqueous solution by new triazole derivatives. Electrochim. Acta, 2004, 49(5), 811-820.
[http://dx.doi.org/10.1016/j.electacta.2003.09.035]
[74]
Qun, J.X.; Sijing, D.; Hong, Y. Inhibition action and adsorption behavior of 3-amino-1,2,4-triazole on copper in 3% NaCl solution. Adv. Mat. Res., 2010, 148-149, 1343-1346.
[75]
Sherif, S.M.; Erasmus, R.M.; Comins, J.D. Corrosion of copper in aerated synthetic sea water solutions and its inhibition by 3-amino-1,2,4-triazole. J. Colloid Interface Sci., 2007, 309(2), 470-477.
[http://dx.doi.org/10.1016/j.jcis.2007.01.003] [PMID: 17346723]
[76]
Sherif, S.M.; Erasmus, R.M.; Comins, J.D. Effects of 3-amino-1,2,4-triazole on the inhibition of copper corrosion in acidic chloride solutions. J. Colloid Interface Sci., 2007, 311(1), 144-151.
[http://dx.doi.org/10.1016/j.jcis.2007.02.064] [PMID: 17416388]
[77]
Trachli, B.; Keddam, M. Protective effect of electropolymerized 3-amino-1,2,4-Triazole towards corrosion of copper in 0.5 M NaCl. Corros. Sci., 2002, 44(2), 997-1008.
[http://dx.doi.org/10.1016/S0010-938X(01)00124-X]
[78]
Godovikova, T.N.; Rakitin, O.A.; Khmelnitsky, L.I. Diazotization in highly acidic environments of weakly basic aromatic and heterocyclic amines. Usp. Khim., 1983, 52(5), 777-786.
[http://dx.doi.org/10.1070/RC1983v052n05ABEH002830]
[79]
Stepanov, S. D.; Pevsner, M. S.; Temchenko, T. P. Diazocompounds in the series 1,2,4-triazole. Structure and transformations of diazotization products of 1-methyl-3-amino-5-R-1,2,4-triazoles. Zh.org.kh, 1988, 24(10), 2145-2151.
[80]
Venkataraman, K. Chemistry of Synthetic Dyes; Khimiya: Leningrad, 1975, p. 4.
[81]
Vinyukova, G.N. Chemistry of Dyes; Khimiya: Moscow, 1979.
[82]
Bratichak, M.M. Peroxide Derivatives of Epoxy Resins; Publishing house of NU "Lviv Polytechnic": Lviv 2003.
[83]
Bratychak, M.; Astakhova, O.; Shyshchak, O.; Zubal, O.; Sienkiewicz, M.; Ivashkiv, O. Epoxy composites filled with natural calcium carbonate. 1. Epoxy composites obtained in the presence of monoperoxy derivative of epidian-6 epoxy resin. Chem. Chem. Technol., 2019, 13(3), 360-364.
[http://dx.doi.org/10.23939/chcht13.03.360]
[84]
Bratychak, M.; Brostow, W. Synthesis and properties of peroxy derivatives of epoxy resins based on Bisphenol A. 1. Effects of the presence of inorganic bases. Polym. Eng. Sci., 1999, 39(8), 1541-1549.
[http://dx.doi.org/10.1002/pen.11547]
[85]
Bratychak, M.; Bashta, B.; Astakhova, O.; Shyshchak, O.; Zubal, O. Synthesis mechanism and properties of epoxy resins modified with adipic acid. Chem. Chem. Technol., 2019, 13(1), 52-58.
[http://dx.doi.org/10.23939/chcht13.01.052]
[86]
Bratychak, M.; Brostow, W.; Donchak, V. Functional peroxides and peroxy oligoesters on the basis of pyromellitic dianhydride. Mater. Res. Innov., 2002, 5(6), 250-256.
[http://dx.doi.org/10.1007/s10019-002-0166-6]
[87]
Desenko, S.M.; Orlov, V.D. Folio publ: Kharkiv, Azageterocycles based on aromatic non-specific ketones 1998.
[88]
Izatt, G.C.; Lindh, R.L.; Bruening, R.; Huszthy, C.W.; McDaniel, C.W.; Bradshaw, J.S.; Christensen, J.J. Separation of silver from other metal cations using pyridine and triazole macrocycles in liquid membrane systems. Anal. Chem., 1988, 60(17), 1694-1699.
[http://dx.doi.org/10.1021/ac00168a013]
[89]
Gad, E.K.; Mahmoud, A. Synthesis of surface active agents from some novel class of oxadiazole, thiadiazole and triazole derivatives having microbiological activities. J. Surfactants Deterg., 2013, 17(3), 509-523.
[http://dx.doi.org/10.1007/s11743-013-1530-9]
[90]
Lamanna, M.E.; De la Horra, E.; Jacobo, S. Synthesis of an organic semiconductor by polymerization of 3-amino-1,2,4-triazole. React. Funct. Polym., 2009, 69(10), 759-765.
[http://dx.doi.org/10.1016/j.reactfunctpolym.2009.06.005]
[91]
Zheng, Y.; Li, S.; Weng, Z.; Gao, C. Hyperbranched polymers: Advances from synthesis to applications. Chem. Soc. Rev., 2015, 44(12), 4091-4130.
[http://dx.doi.org/10.1039/C4CS00528G] [PMID: 25902871]
[92]
Wu, X.; Tong, H.; Wang, L. Fluorescent polymer materials for detection of explosives. Prog. Chem., 2019, 31(11), 1509-1527.
[http://dx.doi.org/10.7536/PC190734]
[93]
Wu, Y.; Qin, A.; Tang, B.Z. AIE-active polymers for explosive detection. Chin. J. Polym. Sci., 2017, 35(2), 141-154.
[http://dx.doi.org/10.1007/s10118-017-1882-0]
[94]
Zhou, H.; Chua, M.H.; Tang, B.Z.; Xu, J. Aggregation-Induced Emission (AIE)-active polymers for explosive detection. Polym. Chem., 2019, 10(28), 3822-3840.
[http://dx.doi.org/10.1039/C9PY00322C]
[95]
Chi, W.W.; Zhang, R.Y.; Han, T.; Du, J.; Li, H.K.; Zhang, W-J.; Li, Y-F.; Tang, B.Z. Facile synthesis of functional poly(methyltriazolylcarboxylate)s by solvent- and catalyst-free butynoate-azide polycycloaddition. Chin. J. Polym. Sci., 2020, 38(1), 17-23.
[http://dx.doi.org/10.1007/s10118-019-2316-y]
[96]
Lang, M.N.; Chi, W.W.; Han, T.; Zhao, Q-Z.; Li, H-K.; Tang, B.Z.; Li, Y-F. Synthesis of Functional Hyperbranched Poly(methyltriazolylcarboxylate)s by Catalyst-free click Polymerization of Butynoates and Azides. Chin. J. Polym. Sci., 2020, 38(11), 1171-1177.
[http://dx.doi.org/10.1007/s10118-020-2421-y]

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Request history8.2.27PHP Version531msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[20:52:42] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[20:52:42] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[20:52:42] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[20:52:42] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (149ms)time
  • Application (383ms)time
  • 1 x Application (72.02%)
    383ms
    1 x Booting (27.98%)
    149ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    36 statements were executed, 4 of which were duplicates, 32 unique. Show only duplicated250ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59081319','',1,1740775962,1740775962) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740775962
      1.36msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59081319','/article/122104',1,1740775962,1740775962)
      250μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59081319 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59081319) limit 1
      22msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59081319
      • 1: 59081319
      • 2: 59081319
      • 3: 59081319
      • 4: 59081319
      • 5: 59081319
      • 6: 59081319
      • 7: 59081319
      • 8: 59081319
      • 9: 59081319
      • 10: 59081319
      • 11: 59081319
      • 12: 59081319
      • 13: 59081319
      • 14: 59081319
      • 15: 59081319
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=122104
      1.12msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 45 limit 1
      1.17msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 45
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and sj.journal_id!=45 group by `j`.`nid`) as `aggregate_table`
      850μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and sj.journal_id!=45 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      760μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.28msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.14msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '122104'
      1.65msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 122104
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '122104'
      4.21msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 122104
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '122104' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 122104
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      370μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      770μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 45 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      44.92msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 45 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      19.9msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 45 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      18.27msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 122104 limit 1
      13.43msalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 122104
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 122104 and content_type = 'article' order by status desc limit 1
      470μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 202910 limit 1
      340μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 202910
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      370μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'MROC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      450μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: MROC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '122104' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      600μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12341' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      520μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3343' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      480μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3343) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3343) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3343)
      85.64msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12341) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12341) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12341)
      1.31msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 122104) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 122104) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59081319 and j.to_ip >=59081319 )) and ((j.from_date <= 1740775962 and j.to_date >= 1740775962 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 122104)
      1.22msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '394' and is_uploaded = 1 and issue_id = 12341 order by cast(first_page as SIGNED) desc limit 1
      890μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 394
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '402' and is_uploaded = 1 and issue_id = 12341 order by cast(first_page as SIGNED) asc limit 1
      720μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 402
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      260μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      440μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 122104 limit 1
      14.08msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 122104
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 45 and `b`.`banner_from_date` <= 1740775962 and `b`.`banner_to_date` >= 1740775962 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      3.47msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 45
      • 3: 1740775962
      • 4: 1740775962
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 45 and `b`.`banner_from_date` <= 1740775962 and `b`.`banner_to_date` >= 1740775962 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.69msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 45
      • 3: 1740775962
      • 4: 1740775962
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='ff1cfb93674ad2b6ef6f75f31a033fc3'
      330μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        TfMZnlf2zh5xYlLfC1gBwATTYhhUWCkOVl97MClu
        uc_cart_id
        ff1cfb93674ad2b6ef6f75f31a033fc3
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/122104" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/122104
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjZPMDgvQ054MjkzWUd1dDAwa2oyQXc9PSIsInZhbHVlIjoiZXlIT0s5YWVUMVFmYmlPMTcwb05JeXJ1UEtZMXJkZUpTb3dnMVhSRWpjVT0iLCJtYWMiOiIwMDRmNjI1ZGJiZDFiYzkyMTJmYzZmNWU1MmI0ZGQ3MDcyYzdmZmVkYmQ1YTI4YTEzYzhhOTc0M2UzM2Y1NTNhIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjZPMDgvQ054MjkzWUd1dDAwa2oyQXc9PSIsInZhbHVlIjoiZXlIT0s5YWVUMVFmYmlPMTcwb05JeXJ1UEtZMXJkZUpTb3dnMVhSRWpjVT0iLCJtYWMiOiIwMDRmNjI1ZGJiZDFi" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
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