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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Case Report

Uterine Tumor Resembling Ovarian Sex Cord Tumors (UTROSCT): Two Case Reports of the Rare Uterine Neoplasm with Literature Review

Author(s): Li Pang, Yawen Dai, Fang Ren, Xu Peng and Zhiqiang Guo*

Volume 18, Issue 10, 2022

Published on: 14 June, 2022

Article ID: e250322202619 Pages: 7

DOI: 10.2174/1573405618666220325095615

Price: $65

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Abstract

Introduction: Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare neoplasms with unknown etiology. This type of tumor has low malignant potential and mostly manifests as a benign clinical course.

Materials and Methods: This article analyzes the case data, clinical manifestations, and histopathological characteristics of two cases of UTROSCT, and reviews the relevant literature. The diagnosis of UTROSCT is mainly based on histopathological examination. The histological characteristics of granulosa and Sertoli cell tumours are similar to the ovary under the microscope. These cases' clinical and radiological (MRI) findings have also been discussed.

Results: The sex cord components are mixed in different proportions. The immunohistochemistry is diverse and can express sex cord markers together with both epithelial and smooth muscle markers. Both two cases revealed the signs of intratumoral cystic degeneration, intratumoral hemorrhage, and necrosis under MRI. These MRI features were helpful to prompt UTROSCT, which is histologically similar to granular cell tumors and is conducive to the differential diagnosis.

Conclusion: The current recommended treatment is total hysterectomy, but its biological behavior is not yet clear, and long-term follow-up is needed.

Keywords: Uterine tumors resembling ovarian sex cord tumors (UTROSCT), iconography, histopathology, immunohistochemistry, smooth muscle markers, MRI.

Graphical Abstract

[1]
Clement PB, Scully RE. Uterine tumors resembling ovarian sex-cord tumors. A clinicopathologic analysis of fourteen cases. Am J Clin Pathol 1976; 66(3): 512-25.
[http://dx.doi.org/10.1093/ajcp/66.3.512] [PMID: 961630]
[2]
Clement PB, Scully RE. Uterine tumors with mixed epithelial and mesenchymal elements. Semin Diagn Pathol 1988; 5(2): 199-222.
[PMID: 2840723]
[3]
Vajpeyi R. WHO classification of tumours: Pathology and genetics of tumours of the breast and female genital organs. J Clin Pathol 2005; 58(6): 671-2.
[PMID: 15917428]
[4]
Pradhan D, Mohanty SK. Uterine tumors resembling ovarian sex cord tumors. Arch Pathol Lab Med 2013; 137(12): 1832-6.
[http://dx.doi.org/10.5858/arpa.2012-0634-RS] [PMID: 24283865]
[5]
Blake EA, Sheridan TB, Wang KL, et al. Clinical characteristics and outcomes of Uterine Tumors Resembling Ovarian Sex-Cord Tumors (UTROSCT): A systematic review of literature. Eur J Obstet Gynecol Reprod Biol 2014; 181: 163-70.
[http://dx.doi.org/10.1016/j.ejogrb.2014.07.050] [PMID: 25150955]
[6]
Morikawa K, Hatabu H, Togashi K, Kataoka ML, Mori T, Konishi J. Granulosa cell tumor of the ovary: MR findings. J Comput Assist Tomogr 1997; 21(6): 1001-4.
[http://dx.doi.org/10.1097/00004728-199711000-00028] [PMID: 9386298]
[7]
Nguyen CV, Phung HT, Dao LT, Ta DHH, Tran MN. Uterine tumor resembling ovarian sex cord tumor: Clinicopathological characteristics of a rare case. Case Rep Oncol 2020; 13(2): 807-12.
[http://dx.doi.org/10.1159/000508180] [PMID: 32884523]
[8]
Irving JA, Carinelli S, Prat J. Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differen-tiation. Mod Pathol 2006; 19(1): 17-24.
[http://dx.doi.org/10.1038/modpathol.3800475] [PMID: 16118629]
[9]
Oliva E, Carcangiu MK, Carinelli SG, et al. Mesenchymal tumours WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon: International Agency for Research on Cancer 2014; pp. 135-47.
[10]
Takeuchi M, Matsuzaki K, Bando Y, Nishimura M, Hayashi A, Harada M. A case of Uterine Tumor Resembling Ovarian Sex-cord Tumor (UTROSCT) exhibiting similar imaging characteristics to those of ovarian sex-cord tumor. Magn Reson Med Sci 2019; 18(2): 113-4.
[http://dx.doi.org/10.2463/mrms.ci.2017-0177] [PMID: 29794407]
[11]
Bakula-Zalewska E, Danska-Bidzinska A, Kowalewska M, Piascik A, Nasierowska-Guttmejer A, Bidzinski M. Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases. Ann Diagn Pathol 2014; 18(6): 329-32.
[http://dx.doi.org/10.1016/j.anndiagpath.2014.08.009] [PMID: 25257516]
[12]
Liu CY, Shen Y, Zhao JG, Qu PP. Clinical experience of uterine tumors resembling ovarian sex cord tumors: A clinicopathological analysis of 6 cases. Int J Clin Exp Pathol 2015; 8(4): 4158-64.
[PMID: 26097607]
[13]
de Leval L, Lim GS, Waltregny D, Oliva E. Diverse phenotypic profile of uterine tumors resembling ovarian sex cord tumors: An immuno-histochemical study of 12 cases. Am J Surg Pathol 2010; 34(12): 1749-61.
[http://dx.doi.org/10.1097/PAS.0b013e3181f8120c] [PMID: 21084963]
[14]
Thakur A, Malhotra V, Sachan S, Aggarwal A. Uterine tumor resembling ovarian sex cord tumor: Histomorphological features. Indian J Pathol Microbiol 2018; 61(1): 131-3.
[http://dx.doi.org/10.4103/IJPM.IJPM_702_16] [PMID: 29567903]
[15]
Chang B, Bai Q, Liang L, Ge H, Yao Q. Recurrent uterine tumors resembling ovarian sex-cord tumors with the growth regulation by estro-gen in breast cancer 1-nuclear receptor coactivator 2 fusion gene: A case report and literature review. Diagn Pathol 2020; 15(1): 110.
[http://dx.doi.org/10.1186/s13000-020-01025-8] [PMID: 32921307]
[16]
Sadeh R, Segev Y, Schmidt M, Schendler J, Baruch T, Lavie O. Uterine tumors resembling ovarian sex cord tumors: Case report of rare pathological and clinical entity. Case Rep Obstet Gynecol 2017; 2017: 2736710.
[http://dx.doi.org/10.1155/2017/2736710] [PMID: 29085684]
[17]
Schraag SM, Caduff R, Dedes KJ, Fink D, Schmidt AM. Uterine tumors resembling ovarian sex cord tumors - treatment, recurrence, preg-nancy and brief review. Gynecol Oncol Rep 2017; 19: 53-6.
[http://dx.doi.org/10.1016/j.gore.2017.01.004] [PMID: 28119954]
[18]
Hillard JB, Malpica A, Ramirez PT. Conservative management of a uterine tumor resembling an ovarian sex cord-stromal tumor. Gynecol Oncol 2004; 92(1): 347-52.
[http://dx.doi.org/10.1016/j.ygyno.2003.09.011] [PMID: 14751183]
[19]
Berretta R, Patrelli TS, Fadda GM, Merisio C, Gramellini D, Nardelli GB. Uterine tumors resembling ovarian sex cord tumors: A case report of conservative management in young women. Int J Gynecol Cancer 2009; 19(4): 808-10.
[http://dx.doi.org/10.1111/IGC.0b013e3181a417b4] [PMID: 19509593]
[20]
Endo D, Todo Y, Okamoto K, Suzuki H. A case of recurrent group II uterine tumor resembling ovarian sex-cord tumors, against which two hormonal agents were ineffective. Taiwan J Obstet Gynecol 2016; 55(5): 751-3.
[http://dx.doi.org/10.1016/j.tjog.2015.04.008] [PMID: 27751432]
[21]
Sato M, Yano M, Sato S, et al. Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) with sarcomatous features without recurrence after extended radical surgery: A case report. Medicine (Baltimore) 2020; 99(11): e19166.
[http://dx.doi.org/10.1097/MD.0000000000019166] [PMID: 32176042]
[22]
Zhang X, Zou S, Gao B, Qu W. Uterine tumor resembling ovarian sex cord tumor: A clinicopathological and immunohistochemical analysis of two cases and a literature review. J Int Med Res 2019; 47(3): 1339-47.
[http://dx.doi.org/10.1177/0300060518821824] [PMID: 30732515]
[23]
Kao YC, Lee JC. An update of molecular findings in uterine tumor resembling ovarian sex cord tumor and GREB1-rearranged uterine sar-coma with variable sex-cord differentiation. Genes Chromosomes Cancer 2021; 60(3): 180-9.
[http://dx.doi.org/10.1002/gcc.22909] [PMID: 33099842]
[24]
Ye S, Wu J, Yao L, He J. Clinicopathological characteristics and genetic variations of uterine tumours resembling ovarian sex cord tumours. J Clin Pathol 2021; 2021-207441.
[http://dx.doi.org/10.1136/jclinpath-2021-207441] [PMID: 34348985]
[25]
Bennett JA, Lastra RR, Barroeta JE, et al. Uterine Tumor Resembling Ovarian Sex Cord Stromal Tumor (UTROSCT): A series of 3 cases with extensive rhabdoid differentiation, malignant behavior, and ESR1-NCOA2 fusions. Am J Surg Pathol 2020; 44(11): 1563-72.
[http://dx.doi.org/10.1097/PAS.0000000000001543] [PMID: 32675660]

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