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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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General Review Article

Current Overview on the Potency of Natural Products for Modulating Myeloid-derived Suppressor Cells Dependent Cold Tumors

Author(s): RamaRao Malla*, Lalitha Pappu, Krishna Chaitanya Amajala and Mohammad Amjad Kamal

Volume 29, Issue 40, 2022

Published on: 13 May, 2022

Page: [6197 - 6216] Pages: 20

DOI: 10.2174/0929867329666220324143215

Price: $65

Abstract

Ample data pertaining to the use of MDSCs have been documented. However, the potency of natural products in targeting MDSCs in the light of the tumor immune microenvironment (TME) has not been discussed vividly. The current review is an amalgamation of the documented literature pertaining to the effectiveness of various natural products supported by in silico experimental data. The combination of bioinformatics to wet bench experimentation with natural products against cancer specifically targeting MDSCs can be a promising approach to mitigate cancer.

Keywords: Cold tumors, computational approaches, natural products, myeloid-derived suppressor cells, tumor immune microenvironment.

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