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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Review Article

Chemical Constituents Based Approach for the Management of Diabetes

Author(s): Prerna Sharma, Nidhi Rani*, Aishwarya Gangwar, Randhir Singh Dahiya and Nitin Verma

Volume 19, Issue 5, 2023

Published on: 20 August, 2022

Article ID: e220322202506 Pages: 9

DOI: 10.2174/1573399818666220322095033

Price: $65

Abstract

Background: A number of complexities in compliance with long-term diabetes have been elicited. It has become a global concern without any convincing medicinal, therapeutical methodology. Both hyperglycaemia and oxidative pressure are major notable parts that play a significant role in the initialization of diabetic inconvenience. Natural medications have gained a lot of attention in recent years as expected restorative specialists in the prevention and treatment of diabetic complications due to their many objectives and less poisonous outcomes. This survey means to evaluate the accessible information on therapeutic spices for constriction and the executives of diabetic complications.

Materials and Methods: Bibliographic investigation was accomplished by checking old-style course books and papers, directing overall bases of logical information (SCOPUS, PUBMED, SCIELO, Google Scholar, NISCAIR,) to recapture accessible distributed writing.

For the assessment of plants with the potential in calming diabetic complications, several inclusion models rely on the numerous medicinal spices as well as their crucial mixes. Furthermore, several models, including plants, have been considered, each of which has a suitable impact on increasing oxidative pressure in diabetes.

Results: Different therapeutic plants/plant withdrawals containing alkaloids, terpenoids, phenolic compounds, flavonoids, saponins, and phytosterol-type synthetic constituents were uncovered that are profitable in the administration of diabetic complexities. Results may be attributed to the improvement of oxidative pressure, constant hyperglycemia, and twitch of different metabolic pathways related to the pathogenesis of diabetic confusions.

Conclusion: An optimistic approach for new medication terminology to treat diabetic confusion is screening compound competitors from homegrown medication. Investigation of the activity of different plant extracts as well as their potency profile and to determine their job in the treatment of diabetic inconveniences must be there. In addition, an ideal rat model which imitates human diabetic complications ought to be created.

Keywords: Diabetes, hyperglycemia, oxidative pressure, obesity, plant constituents, diabetic complications.

[1]
Duckworth WC. Hyperglycemia and cardiovascular disease. Curr Atheroscler Rep 2001; 3(5): 383-91.
[http://dx.doi.org/10.1007/s11883-001-0076-x] [PMID: 11487449]
[2]
Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesticides and oxidative stress: A review. Med Sci Monit 2004; 10(6): RA141-7.
[PMID: 15173684]
[3]
Naziroglu M, Butterworth PJ. Protective effects of moderate exercise with dietary vitamin C and E on blood antioxidative defense mechanism in rats with streptozotocin-induced diabetes. Can J Appl Physiol 2005; 30(2): 172-85.
[http://dx.doi.org/10.1139/h05-113] [PMID: 15981786]
[4]
Gopaul NK, Anggard EE, Mallet AI, et al. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with NIDDM. FEBS Lett 1995; 368: 225-9.
[http://dx.doi.org/10.1016/0014-5793(95)00649-T] [PMID: 7628610]
[5]
Davì G, Ciabattoni G, Consoli A, et al. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation. Circulation 1999; 99(2): 224-9.
[http://dx.doi.org/10.1161/01.CIR.99.2.224] [PMID: 9892587]
[6]
Vessby J, Basu S, Mohsen R, Berne C, Vessby B. Oxidative stress and antioxidant status in type 1 diabetes mellitus. J Intern Med 2002; 251(1): 69-76.
[http://dx.doi.org/10.1046/j.1365-2796.2002.00927.x] [PMID: 11851867]
[7]
Astaneie F, Afshari M, Mojtahedi A, et al. Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Arch Med Res 2005; 36(4): 376-81.
[http://dx.doi.org/10.1016/j.arcmed.2005.03.007] [PMID: 15950078]
[8]
Penckofer S, Schwertz D, Florczak K. Oxidative stress and cardiovascular disease in type 2 diabetes: The role of antioxidants and pro-oxidants. J Cardiovasc Nurs 2002; 16(2): 68-85.
[http://dx.doi.org/10.1097/00005082-200201000-00007] [PMID: 11800069]
[9]
Shih CC, Wu YW, Lin WC. Antihyperglycaemic and anti-oxidant properties of Anoectochilus formosanus in diabetic rats. Clin Exp Pharmacol Physiol 2002; 29(8): 684-8.
[http://dx.doi.org/10.1046/j.1440-1681.2002.03717.x] [PMID: 12100000]
[10]
Jialal I, Devaraj S, Venugopal SK. Oxidative stress, inflammation, and diabetic vasculopathies: The role of alpha tocopherol therapy. Free Radic Res 2002; 36(12): 1331-6.
[http://dx.doi.org/10.1080/1071576021000038531] [PMID: 12607825]
[11]
Kedziora-Kornatowska KZ, Luciak M, Paszkowski J. Lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney: Effect of treatment with angiotensin convertase inhibitors. IUBMB Life 2000; 49(4): 303-7.
[http://dx.doi.org/10.1080/15216540050033177] [PMID: 10995033]
[12]
Anjaneyulu M, Chopra K. Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats. Pharmacology 2004; 72(1): 42-50.
[http://dx.doi.org/10.1159/000078631] [PMID: 15292654]
[13]
Baydas G, Reiter RJ, Yasar A, Tuzcu M, Akdemir I, Nedzvetskii VS. Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Free Radic Biol Med 2003; 35(7): 797-804.
[http://dx.doi.org/10.1016/S0891-5849(03)00408-8] [PMID: 14583344]
[14]
Kowluru RA, Koppolu P, Chakrabarti S, Chen S. Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radic Res 2003; 37(11): 1169-80.
[http://dx.doi.org/10.1080/10715760310001604189] [PMID: 14703729]
[15]
Chung YS, Choi YH, Lee SJ, et al. Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo. J Ethnopharmacol 2005; 59: 365-73.
[16]
Ryu JK, Lee T, Kim DJ, et al. Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats. Urology 2005; 65(3): 611-5.
[http://dx.doi.org/10.1016/j.urology.2004.10.038] [PMID: 15780402]
[17]
Reunanen A, Knekt P, Aaran RK, Aromaa A. Serum antioxidants and risk of non-insulin dependent diabetes mellitus. Eur J Clin Nutr 1998; 52(2): 89-93.
[http://dx.doi.org/10.1038/sj.ejcn.1600519] [PMID: 9505151]
[18]
Willems D, Dorchy H, Dufrasne D. Serum antioxidant status and oxidized LDL in well-controlled young type 1 diabetic patients with and without subclinical complications. Atherosclerosis 1998; 137 (Suppl.): S61-4.
[http://dx.doi.org/10.1016/S0021-9150(97)00320-1] [PMID: 9694543]
[19]
Feillet C, Roche B, Tauveron I, et al. Susceptibility to oxidation and physicochemical properties of LDL in insulin-dependent diabetics. Atherosclerosis 1998; 136(2): 405-7.
[PMID: 9543114]
[20]
Lee DH, Folsom AR, Harnack L, Halliwell B, Jacobs DRJ. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004; 80(5): 194-1200.
[http://dx.doi.org/10.1093/ajcn/80.5.1194]
[21]
Chanwitheesuk A, Teerawutgulrag A, Rakariyatham N. Screening of antioxidant activity and antioxidant compounds of some edible plants of Thailand. Food Chem 2005; 92: 491-7.
[http://dx.doi.org/10.1016/j.foodchem.2004.07.035]
[22]
Larkins N, Wynn S. Pharmacognosy: Phytomedicines and their mechanisms. Vet Clin North Am Small Anim Pract 2004; 34(1): 291-327.
[http://dx.doi.org/10.1016/j.cvsm.2003.09.006] [PMID: 15032133]
[23]
Sonta T, Inoguchi T, Matsumoto S, et al. In vivo imaging of oxidative stress in the kidney of diabetic mice. Biochem Biophys Res Commun 2005; 330: 415-22.
[http://dx.doi.org/10.1016/j.bbrc.2005.02.174] [PMID: 15796899]
[24]
Maritim AC, Moore BH, Sanders RA, Watkins JB. Effects of melatonin on oxidative stress in streptozicin-induced diabetic rats. IntToxicol 1999; 18: 161-6.
[25]
Cam M, Yavuz O, Guven A, Ercan F, Bukan N, Ustündag N. Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats. J Pineal Res 2003; 35(3): 212-20.
[http://dx.doi.org/10.1034/j.1600-079X.2003.00082.x] [PMID: 12932206]
[26]
Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 2004; 11(9): 1135-46.
[http://dx.doi.org/10.2174/0929867043365387] [PMID: 15134511]
[27]
Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 1999; 16(12): 1040-3.
[http://dx.doi.org/10.1046/j.1464-5491.1999.00190.x] [PMID: 10656234]
[28]
Elmalí E, Altan N, Bukan N. Effect of the sulphonylurea glibenclamide on liver and kidney antioxidant enzymes in streptozocin-induced diabetic rats. Drugs R D 2004; 5(4): 203-8.
[http://dx.doi.org/10.2165/00126839-200405040-00003] [PMID: 15230625]
[29]
Tüzün S, Girgin FK, Sözmen EY, Menteş G, Ersöz B. Antioxidant status in experimental type 2 diabetes mellitus: Effects of glibenclamide and glipizide on various rat tissues. Exp Toxicol Pathol 1999; 51(4-5): 436-41.
[http://dx.doi.org/10.1016/S0940-2993(99)80036-0] [PMID: 10445412]
[30]
Desco MC, Asensi M, Márquez R, et al. Xanthine oxidase is involved in free radical production in type 1 diabetes: Protection by allopurinol. Diabetes 2002; 51(4): 1118-24.
[http://dx.doi.org/10.2337/diabetes.51.4.1118] [PMID: 11916934]
[31]
Afshari M, Larijani B, Rezaie A, et al. Ineffectiveness of allopurinol in reduction of oxidative stress in diabetic patients; a randomized, double-blind placebo-controlled clinical trial. Biomed Pharmacother 2004; 58(10): 546-50.
[http://dx.doi.org/10.1016/j.biopha.2004.09.012] [PMID: 15589061]
[32]
Ouslimani N, Peynet J, Bonnefont-Rousselot D, Thérond P, Legrand A, Beaudeux JL. Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells. Metabolism 2005; 54(6): 829-34.
[http://dx.doi.org/10.1016/j.metabol.2005.01.029] [PMID: 15931622]
[33]
Radfar M, Larijani B, Hadjibabaie M, Rajabipour B, Mojtahedi A, Abdollahi M. Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial. Biomed Pharmacother 2005; 59(6): 302-6.
[http://dx.doi.org/10.1016/j.biopha.2005.05.003] [PMID: 15932791]
[34]
Gumieniczek A, Hopkała H, Roliński J, Bojarska-Junak A. Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals. Pharmacol Res 2005; 52(2): 162-6.
[http://dx.doi.org/10.1016/j.phrs.2005.02.019] [PMID: 15967382]
[35]
Abdollahi M, Bahreini-Moghadam A, Emami B, Fooladian F, Zafari K. Increasing intracellular cAMP and cGMP inhibits cadmium-induced oxidative stress in rat submandibular saliva. Comp Biochem Physiol 2003; 135: 331-6.
[36]
Abdollahi M, Fooladian F, Emami B, Zafari K, Bahreini-Moghadam A. Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat submandibular gland and saliva. Hum Exp Toxicol 2003; 22: 587-92.
[http://dx.doi.org/10.1191/0960327103ht399oa] [PMID: 14686481]
[37]
Abdollahi M, Chan TS, Subrahmanyam V, O’Brien PJ. Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol Cell Biochem 2003; 252(1-2): 205-11.
[http://dx.doi.org/10.1023/A:1025568714217] [PMID: 14577594]
[38]
Keller JN, Hanni KB, Mattson MP, Markesbery WR. Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity. Neuroreport 1998; 9(16): 3731-4.
[http://dx.doi.org/10.1097/00001756-199811160-00029] [PMID: 9858387]
[39]
Kohda Y, Gemba M. Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices. Jpn J Pharmacol 2001; 85(1): 54-9.
[http://dx.doi.org/10.1254/jjp.85.54] [PMID: 11243575]
[40]
Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH. Postexposure treatment with aminophylline protects against phosgene-induced acute lung injury. Exp Lung Res 1997; 23(4): 317-32.
[http://dx.doi.org/10.3109/01902149709039229] [PMID: 9202957]
[41]
Zhang H, Kim YK, Govindarajan A, et al. Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants. Am J Respir Crit Care Med 1999; 160(5 Pt 1): 1703-10.
[http://dx.doi.org/10.1164/ajrccm.160.5.9903068] [PMID: 10556144]
[42]
Zhang H, Zheng RL, Xu CY. Relationships between lipid peroxidation or cyclic nucleotides and motility in human asthenozoosperm and normosperm. Shih Yen Sheng Wu Hsueh Pao 1998; 31(4): 341-6.
[PMID: 12016956]
[43]
Aydin A, Orhan H, Sayal A, Ozata M, Sahin G, Işimer A. Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: Effects of glycemic control. Clin Biochem 2001; 34(1): 65-70.
[http://dx.doi.org/10.1016/S0009-9120(00)00199-5] [PMID: 11239518]
[44]
Milani E, Nikfar S, Khorasani R, Zamani MJ, Abdollahi M. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comp Biochem Physiol C Toxicol Pharmacol 2005; 140(2): 251-5.
[http://dx.doi.org/10.1016/j.cca.2005.02.010] [PMID: 15907769]
[45]
Okutan H, Ozcelik N, Yilmaz HR, Uz E. Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clin Biochem 2005; 38(2): 191-6.
[http://dx.doi.org/10.1016/j.clinbiochem.2004.10.003] [PMID: 15642285]
[46]
Fiordaliso F, Bianchi R, Staszewsky L, et al. Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J Mol Cell Cardiol 2004; 37(5): 959-68.
[http://dx.doi.org/10.1016/j.yjmcc.2004.07.008] [PMID: 15522273]
[47]
Rota R, Chiavaroli C, Garay RP, Hannaert P. Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats. Eur J Pharmacol 2004; 495(2-3): 217-24.
[http://dx.doi.org/10.1016/j.ejphar.2004.05.019] [PMID: 15249173]
[48]
Dulin B, Abraham WT. Pharmacology of carvedilol. Am J Cardiol 2004; 93(9A): 3B-6B.
[http://dx.doi.org/10.1016/j.amjcard.2004.01.003] [PMID: 15144929]
[49]
Castro P, Vukasovic JL, Chiong M, et al. Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure. Eur J Heart Fail 2005; 7(6): 1033-9.
[http://dx.doi.org/10.1016/j.ejheart.2004.11.009] [PMID: 16227141]
[50]
Oliveira PJ, Gonçalves L, Monteiro P, Providencia LA, Moreno AJ. Are the antioxidant properties of carvedilol important for the protection of cardiac mitochondria? Curr Vasc Pharmacol 2005; 3(2): 147-58.
[http://dx.doi.org/10.2174/1570161053586903] [PMID: 15853634]
[51]
Calò LA, Semplicini A, Davis PA. Antioxidant and antiinflammatory effect of carvedilol in mononuclear cells of hypertensive patients. Am J Med 2005; 118(2): 201-2.
[http://dx.doi.org/10.1016/j.amjmed.2004.05.030] [PMID: 15694913]
[52]
Darko D, Dornhorst A, Kelly FJ, Ritter JM, Chowienczyk PJ. Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes. Clin Sci (Lond) 2002; 103(4): 339-44.
[http://dx.doi.org/10.1042/cs1030339] [PMID: 12241530]
[53]
Jacheć W, Tomasik A, Tarnawski R, Chwalińska E. Evidence of oxidative stress in the renal cortex of diabetic rats: Favourable effect of vitamin E. Scand J Clin Lab Invest 2002; 62(1): 81-8.
[http://dx.doi.org/10.1080/003655102753517244] [PMID: 12002418]
[54]
Bursell SE, Clermont AC, Aiello LP, et al. High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care 1999; 22(8): 1245-51.
[http://dx.doi.org/10.2337/diacare.22.8.1245] [PMID: 10480765]
[55]
Ramachandran B, Ravi K, Narayanan V, Kandaswamy M, Subramanian S. Protective effect of macrocyclic binuclear oxovanadium complex on oxidative stress in pancreas of streptozotocin induced diabetic rats. Chem Biol Interact 2004; 149(1): 9-21.
[http://dx.doi.org/10.1016/j.cbi.2004.06.007] [PMID: 15356917]
[56]
Moustafa SA. Biomed Pharmacother 2005; 59: 365-73.
[http://dx.doi.org/10.1016/j.biopha.2005.07.002] [PMID: 16081237]
[57]
Sheng XQ, Huang KX, Xu HB. Influence of alloxan-induced diabetes and selenite treatment on blood glucose and glutathione levels in mice. J Trace Elem Med Biol 2005; 18(3): 261-7.
[http://dx.doi.org/10.1016/j.jtemb.2005.01.001] [PMID: 15966575]
[58]
Liu S, Ajani U, Chae C, Hennekens C, Buring JE, Manson JE. Long-term beta-carotene supplementation and risk of type 2 diabetes mellitus: A randomized controlled trial. JAMA 1999; 282(11): 1073-5.
[http://dx.doi.org/10.1001/jama.282.11.1073] [PMID: 10493207]
[59]
Levy Y, Zaltsberg H, Ben-Amotz A, Kanter Y, Aviram M. Dietary supplementation of a natural isomer mixture of beta-carotene inhibits oxidation of LDL derived from patients with diabetes mellitus. Ann Nutr Metab 2000; 44(2): 54-60.
[http://dx.doi.org/10.1159/000012821] [PMID: 10970993]
[60]
Maritim A, Dene BA, Sanders RA, Watkins JB III. Effects of beta-carotene on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol 2002; 16(4): 203-8.
[http://dx.doi.org/10.1002/jbt.10038] [PMID: 12242690]
[61]
Amer M, El-Habibi S, El-Gendy A. Effects of Trifolium alexandrinum extracts on streptozotocin-induced diabetes in male rats. Ann Nutr Metab 2004; 48(5): 343-7.
[http://dx.doi.org/10.1159/000081664] [PMID: 15499220]
[62]
Iwaia K, Kima MY, Onoderab A, Matsuec H. Physiological effectsand active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress. Biofactor 2004; 21: 273-5.
[http://dx.doi.org/10.1002/biof.552210153]
[63]
Orhan DD, Aslan M, Sendogdu N, Ergun F, Yesilada E. Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocin-diabetic rats. J Ethnopharmacol 2005; 98(1-2): 95-102.
[http://dx.doi.org/10.1016/j.jep.2004.12.033] [PMID: 15763369]
[64]
Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 2005; 51(2): 117-23.
[http://dx.doi.org/10.1016/j.phrs.2004.06.002] [PMID: 15629256]
[65]
Lee JS. Effects of Fomesfomentarius supplementation on antioxidantenzyme activities, blood glucose, and lipid profile in streptozotocininduced diabetic rats. Nutr Res 2005; 25(2): 187-95.

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