Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Case Report

Walking the Risk-Benefit Tight Rope: A Case of Post Fine Needle Aspiration Haemorrhage in Extramedullary Plasmacytoma

Author(s): Deeksha Bhalla, SH Chandrashekhara*, Abdul Razik, Atul Sharma and Rupak Kumar Giri

Volume 18, Issue 9, 2022

Published on: 18 April, 2022

Article ID: e080322201860 Pages: 4

DOI: 10.2174/1573405618666220308102941

Price: $65

Abstract

Background: Primary extramedullary plasmacytomas (EMP) are rare; however, secondary forms may be seen in ~10-15% of patients with systemic multiple myeloma (MM). The diagnosis of EMP is based on the demonstration of monoclonal plasma cells in the lesion, which requires tissue sampling.

Case Presentation: We present a case of a 38 year old female with MM who underwent diagnostic US at our institute. Multiple focal liver lesions were detected, which were suspicious for EMP. She underwent fine needle aspiration cytology (FNAC) for diagnosis, following which she developed hemoperitoneum secondary to deranged clotting parameters (prothrombin time and platelet count). CT angiography revealed active hepatic capsular bleed. She was taken up for percutaneous embolisation, and the supplying vessel successfully embolised using gel foam particles.

Conclusion: Complications may rarely occur in interventional procedures, particularly in patients with comorbidities. However, prompt diagnosis and management help prevent adverse outcomes.

Keywords: Multiple myeloma, plasmacytoma, biopsy, fine needle, hemorrhage, embolisation.

[1]
Galieni P, Cavo M, Avvisati G, et al. Solitary plasmacytoma of bone and extramedullary plasmacytoma: Two different entities? Ann Oncol 1995; 6(7): 687-91.
[http://dx.doi.org/10.1093/oxfordjournals.annonc.a059285] [PMID: 8664190]
[2]
Choi EJ, Kim KA, Park CM, Lee JH, Choi JW, Seol HY. Extramedullary plasmacytoma of the pancreas: Imaging findings: Case report. J Korean Radiol Soc 2003; 49(4): 301.
[http://dx.doi.org/10.3348/jkrs.2003.49.4.301]
[3]
Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: A longitudinal study on 1003 consecutive patients. Ann Oncol 2010; 21(2): 325-30.
[http://dx.doi.org/10.1093/annonc/mdp329] [PMID: 19633044]
[4]
Ryu SW, Cohen-Hallaleh V. Imaging features of extramedullary plasmacytoma. J Med Imaging Radiat Oncol 2020; 64(1): 44-51.
[http://dx.doi.org/10.1111/1754-9485.12975] [PMID: 31785037]
[5]
Sz U. Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents. Haematologica 2012; 97(11): 1761-7.
[http://dx.doi.org/10.3324/haematol.2012.065698]
[6]
Caers J, Paiva B, Zamagni E, et al. Diagnosis, treatment, and response assessment in solitary plasmacytoma: Updated recommendations from a European Expert Panel. J Hematol Oncol 2018; 11(1): 10.
[http://dx.doi.org/10.1186/s13045-017-0549-1] [PMID: 29338789]
[7]
Bangerter M, Hildebrand A, Waidmann O, Griesshammer M. Fine needle aspiration cytology in extramedullary plasmacytoma. Acta Cytol 2000; 44(3): 287-91.
[http://dx.doi.org/10.1159/000328466] [PMID: 10833979]
[8]
Midia M, Odedra D, Shuster A, Midia R, Muir J. Predictors of bleeding complications following percutaneous image-guided liver biopsy: A scoping review. Diagn Interv Radiol 2019; 25(1): 71-80.
[http://dx.doi.org/10.5152/dir.2018.17525] [PMID: 30644369]
[9]
McHugh KE, Policarpio-Nicolas Md MLC, Reynolds JP. Fine-needle aspiration of the liver: A 10-year single institution retrospective re-view. Hum Pathol 2019; 92: 25-31.
[http://dx.doi.org/10.1016/j.humpath.2019.07.007] [PMID: 31351156]
[10]
Goldhoff PE, Vohra P, Kolli KP, Ljung B-M. Fine-needle aspiration biopsy of liver lesions yields higher tumor fraction for molecular stud-ies: A direct comparison with concurrent core needle biopsy. J Natl Compr Canc Netw 2019; 17(9): 1075-81.
[http://dx.doi.org/10.6004/jnccn.2019.7300] [PMID: 31487685]
[11]
Patel IJ, Rahim S, Davidson JC, et al. Society of interventional radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous image-guided interventions-part II: Recommendations: Endorsed by the Canadian association for interventional radiology and the cardiovascular and interventional radiological society of Europe. J Vasc Interv Radiol JVIR 2019; 30(8): 1168-1184.e1.
[http://dx.doi.org/10.1016/j.jvir.2019.04.017] [PMID: 31229333]
[12]
El Maaroufi H, Doghmi K, Rharrassi I, Mikdame M. Extramedullary plasmacytoma of the liver. Hematol Oncol Stem Cell Ther 2012; 5(3): 172-3.
[http://dx.doi.org/10.5144/1658-3876.2012.172] [PMID: 23095797]
[13]
Ghobrial PM, Goel A. Plasmacytoma of liver mimicking hepatocellular carcinoma at multiphasic computed tomography evaluation. J Comput Assist Tomogr 2015; 39(4): 510-2.
[http://dx.doi.org/10.1097/RCT.0000000000000267] [PMID: 26017921]
[14]
Shin H-J, Kim K, Lee JW, et al. Comparison of outcomes after autologous stem cell transplantation between myeloma patients with skeletal and soft tissue plasmacytoma. Eur J Haematol 2014; 93(5): 414-21.
[http://dx.doi.org/10.1111/ejh.12377] [PMID: 24813053]
[15]
Touzeau C, Moreau P. How I treat extramedullary myeloma. Blood 2016; 127(8): 971-6.
[http://dx.doi.org/10.1182/blood-2015-07-635383] [PMID: 26679866]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy