Pharmacological Significance of Synthetic Bioactive Thiazole Derivatives

Title:Pharmacological Significance of Synthetic Bioactive Thiazole Derivatives

Volume: 18 Issue: 9

Author(s): Andleeb Amin, Tanzeela Qadir, Alka Salhotra*, Praveen Kumar Sharma, Ishtiaq Jeelani and Hitoshi Abe

Affiliation:

• Department of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, 144411 Punjab, India

Keywords: Thiazole, heterocyclic compounds, antimicrobial, anticancer, antihistaminic, antioxidant, melanoma, solar elastosis, benzothiazole, thiazolopyrimidine, bioactive derivates.

Abstract: Thiazole and the related nuclei constitute one of the most significant moieties in the extensively emerging domain of heterocyclic compounds. The versatile nature of the thiazole nucleus can be determined as it is present in natural products like vitamin B1. Furthermore, its derivatives exhibit diverse biological activities, including antimicrobial, anticancer, antihistaminic, antioxidant, etc. They have also emerged as potent CNS agents and are primarily used in the treatment of various CNS disorders. The structure-activity relationship of various amine derivatives of ethylated thiazole demonstrates their use as potential agents in the treatment of melanoma, pigmentation as well as solar elastosis. Thiazole fused with different heterocyclic systems results in many novel derivatives with higher therapeutic activity. Benzothiazole and Thiazolopyrimidine have a distinct position in this regard. This review focuses on the central role of thiazole and its derivatives in current drug design, covering a broad spectrum of pharmacological activities associated with them.

Cite this article as:

Amin Andleeb, Qadir Tanzeela, Salhotra Alka*, Sharma Kumar Praveen, Jeelani Ishtiaq and Abe Hitoshi, Pharmacological Significance of Synthetic Bioactive Thiazole Derivatives, Current Bioactive Compounds 2022; 18 (9) : e030322201633 . https://dx.doi.org/10.2174/1573407218666220303100501