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Review Article

小檗碱对化疗所致认知障碍的神经保护作用研究进展

卷 23, 期 9, 2022

发表于: 13 May, 2022

页: [913 - 923] 页: 11

弟呕挨: 10.2174/1389450123666220303094752

价格: $65

摘要

化疗脑是化疗的主要副作用之一;尽管研究越来越多，但化疗导致认知改变的机制仍不清楚。已经确定了几种可能的重要的候选机制，并将在未来进一步研究。化学脑的特点是记忆丧失、认知障碍、语言困难、注意力不集中、加速和学习。化学脑的主要特征是氧化应激、线粒体功能障碍、免疫失调、激素改变、白质异常和DNA损伤。小檗碱(BBR)是从多种小檗碱中提取的一种异喹啉生物碱。血脑屏障是一种小的化学物质，可以很容易地通过血脑屏障(BBB)，使其对治疗神经退行性疾病有用。以往已有许多关于BBR药理作用的研究报道。此外，多项临床和实验研究表明，BBR具有多种药理作用。因此，本文就化学脑的发病机制及脑屏障对化学脑的保护作用进行综述。我们还介绍了BBR在各种神经退行性疾病和神经系统疾病中的治疗作用，如阿尔茨海默病、帕金森病、精神抑郁、精神分裂症、焦虑以及中风。

关键词: 黄连素、线粒体功能障碍、氧化应激、化学脑、认知障碍、神经退行性疾病。

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