Abstract
Background: Garlic (Allium sativum) is used as a natural supplement for the treatment of various diseases and disorders because it has antibacterial, antiviral, antifungal, antiparasitic, antioxidant, and anti-inflammatory properties. This systematic review aimed to evaluate in vitro and in vivo effects of garlic against Schistosoma spp.
Methods: The current study was carried out according to the PRISMA guidelines and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-analysis Facility [SyRF] database. The literature search was conducted using five databases, including Scopus, PubMed, Web of Science, Embase, and Google Scholar, from January 2008 to January 2021. The search was restricted to articles published in the English language. Syntax was performed based on each database tag.
Results: Out of 2,600 studies, 10 met the eligibility criteria for review. The examined parasite in all studies was Schistosoma mansoni. Ten studies (90%) were performed in vivo and one study in vitro. Studies have shown that garlic compounds can activate immune system factors, thereby damaging the parasite structure or its eggs.
Conclusion: Given the increase in using plants in the treatment of many diseases and the fact that plants can be a good alternative to chemical drugs in many cases, more comprehensive research is needed to introduce effective medicinal plants to treat diseases such as schistosomiasis.
Keywords: Schistosomes, in vivo, in vitro, helminthic infection, garlic, Allium sativum.
[1]
Quansah E, Sarpong E, Karikari TK. Disregard of neurological impairments associated with neglected tropical diseases in Africa. eNeurologicalSci 2015; 3: 11-4.
[http://dx.doi.org/10.1016/j.ensci.2015.11.002] [PMID: 28239667]
[http://dx.doi.org/10.1016/j.ensci.2015.11.002] [PMID: 28239667]
[2]
Hirst SI, Stapley LA. Parasitology: the dawn of a new millennium. Parasitol Today 2000; 16(1): 1-3.
[http://dx.doi.org/10.1016/S0169-4758(99)01589-6] [PMID: 10637575]
[http://dx.doi.org/10.1016/S0169-4758(99)01589-6] [PMID: 10637575]
[3]
Hu W, Brindley PJ, McManus DP, Feng Z, Han Z-G. Schistosome transcriptomes: new insights into the parasite and schistosomiasis. Trends Mol Med 2004; 10(5): 217-25.
[http://dx.doi.org/10.1016/j.molmed.2004.03.002] [PMID: 15121048]
[http://dx.doi.org/10.1016/j.molmed.2004.03.002] [PMID: 15121048]
[4]
Colley DG, Bustinduy AL, Secor WE, King CH. Human schistosomiasis. Lancet 2014; 383(9936): 2253-64.
[http://dx.doi.org/10.1016/S0140-6736(13)61949-2] [PMID: 24698483]
[http://dx.doi.org/10.1016/S0140-6736(13)61949-2] [PMID: 24698483]
[5]
Wang W, Wang L, Liang Y-S. Susceptibility or resistance of praziquantel in human schistosomiasis: A review. Parasitol Res 2012; 111(5): 1871-7.
[http://dx.doi.org/10.1007/s00436-012-3151-z] [PMID: 23052781]
[http://dx.doi.org/10.1007/s00436-012-3151-z] [PMID: 23052781]
[6]
Fallon PG, Doenhoff MJ. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 1994; 51(1): 83-8.
[http://dx.doi.org/10.4269/ajtmh.1994.51.83] [PMID: 8059919]
[http://dx.doi.org/10.4269/ajtmh.1994.51.83] [PMID: 8059919]
[7]
Fenwick A, Webster JP. Schistosomiasis: challenges for control, treatment and drug resistance. Curr Opin Infect Dis 2006; 19(6): 577-82.
[http://dx.doi.org/10.1097/01.qco.0000247591.13671.6a] [PMID: 17075334]
[http://dx.doi.org/10.1097/01.qco.0000247591.13671.6a] [PMID: 17075334]
[8]
Goncagul G, Ayaz E. Antimicrobial effect of garlic (Allium sativum). Recent Patents Anti-Infect Drug Disc 2010; 5(1): 91-3.
[http://dx.doi.org/10.2174/157489110790112536] [PMID: 19929845]
[http://dx.doi.org/10.2174/157489110790112536] [PMID: 19929845]
[9]
Bordia T, Mohammed N, Thomson M, Ali M. An evaluation of garlic and onion as antithrombotic agents. Prostaglandins Leukot Essent Fatty Acids 1996; 54(3): 183-6.
[http://dx.doi.org/10.1016/S0952-3278(96)90014-9] [PMID: 8860105]
[http://dx.doi.org/10.1016/S0952-3278(96)90014-9] [PMID: 8860105]
[10]
Mathew BC, Daniel RS, Augusti KT. Hypolipidemic effect of garlic protein substituted for casein in diet of rats compared to those of garlic oil. Indian J Exp Biol 1996; 34(4): 337-40.
[PMID: 8698422]
[PMID: 8698422]
[11]
Jalal R, Bagheri SM, Moghimi A, Rasuli MB. Hypoglycemic effect of aqueous shallot and garlic extracts in rats with fructose-induced insulin resistance. J Clin Biochem Nutr 2007; 41(3): 218-23.
[http://dx.doi.org/10.3164/jcbn.2007031] [PMID: 18299719]
[http://dx.doi.org/10.3164/jcbn.2007031] [PMID: 18299719]
[12]
Karasaki Y, Tsukamoto S, Mizusaki K, Sugiura T, Gotoh S. A garlic lectin exerted an antitumor activity and induced apoptosis in human tumor cells. Food Res Int 2001; 34(1): 7-13.
[http://dx.doi.org/10.1016/S0963-9969(00)00122-8]
[http://dx.doi.org/10.1016/S0963-9969(00)00122-8]
[13]
Worku M, Franco R, Baldwin K. Efficacy of garlic as an anthelmintic in adult Boer goats. Arch Biol Sci 2009; 61(1): 135-40.
[http://dx.doi.org/10.2298/ABS0901135W]
[http://dx.doi.org/10.2298/ABS0901135W]
[14]
Velkers FC, Dieho K, Pecher FW, Vernooij JC, van Eck JH, Landman WJ. Efficacy of allicin from garlic against Ascaridia galli infection in chickens. Poult Sci 2011; 90(2): 364-8.
[http://dx.doi.org/10.3382/ps.2010-01090] [PMID: 21248333]
[http://dx.doi.org/10.3382/ps.2010-01090] [PMID: 21248333]
[15]
Donma MM, Donma O. The effects of Allium sativum on immunity within the scope of COVID-19 infection. Med Hypotheses 2020; 144, 109934.
[http://dx.doi.org/10.1016/j.mehy.2020.109934] [PMID: 32512493]
[http://dx.doi.org/10.1016/j.mehy.2020.109934] [PMID: 32512493]
[16]
Gamboa-León MR, Aranda-González I, Mut-Martín M, García-Miss MR, Dumonteil E. In vivo and in vitro control of Leishmania mexicana due to garlic-induced NO production. Scand J Immunol 2007; 66(5): 508-14.
[http://dx.doi.org/10.1111/j.1365-3083.2007.02000.x] [PMID: 17953527]
[http://dx.doi.org/10.1111/j.1365-3083.2007.02000.x] [PMID: 17953527]
[17]
Lima CMBL, Freitas FI, Morais LC, et al. Ultrastructural study on the morphological changes to male worms of Schistosoma mansoni after in vitro exposure to allicin. Rev Soc Bras Med Trop 2011; 44(3): 327-30.
[http://dx.doi.org/10.1590/S0037-86822011005000023] [PMID: 21537796]
[http://dx.doi.org/10.1590/S0037-86822011005000023] [PMID: 21537796]
[18]
Metwally DM, Al-Olayan EM, Alanazi M, Alzahrany SB, Semlali A. Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo. BMC Complement Altern Med 2018; 18(1): 135.
[http://dx.doi.org/10.1186/s12906-018-2191-z] [PMID: 29703259]
[http://dx.doi.org/10.1186/s12906-018-2191-z] [PMID: 29703259]
[19]
Aly I, Taher EE, El-Sayed H, et al. Efficacy of soluble glycoprotein fraction from Allium sativum purified by size exclusion chromatography on murine Schistosomiasis mansoni. Microb Pathog 2017; 107: 243-8.
[http://dx.doi.org/10.1016/j.micpath.2017.03.039] [PMID: 28373144]
[http://dx.doi.org/10.1016/j.micpath.2017.03.039] [PMID: 28373144]
[20]
Kamel ROA, El-Shinnawy NA. Immunomodulatory effect of garlic oil extract on Schistosoma mansoni infected mice. Asian Pac J Trop Med 2015; 8(12): 999-1005.
[http://dx.doi.org/10.1016/j.apjtm.2015.11.016] [PMID: 26706670]
[http://dx.doi.org/10.1016/j.apjtm.2015.11.016] [PMID: 26706670]
[21]
Mantawy MM, Aly HF, Zayed N, Fahmy ZH. Antioxidant and schistosomicidal effect of Allium sativum and Allium cepa against Schistosoma mansoni different stages. Eur Rev Med Pharmacol Sci 2012; 16(Suppl. 3): 69-80.
[PMID: 22957420]
[PMID: 22957420]
[22]
El-Kott A, Mohammed R, Ismail N. Efficacy of garlic and mirazid in treatment of the liver granuloma in mice infected with Schistosoma mansoni. Res. J Parasitol 2011; 6: 151-9.
[http://dx.doi.org/10.3923/jp.2011.151.159]
[http://dx.doi.org/10.3923/jp.2011.151.159]
[23]
Riad NH, Taha HA, Mahmoud YI. Effects of garlic on albino mice experimentally infected with Schistosoma mansoni: a parasitological and ultrastructural study. Troical biomedicine 2009; 26[1]:: 40-50.
[24]
Abdel-Salam A, Ammar N, Abdel-Hamid A. Effectiveness of probiotic Labneh supplemented with garlic or onion oil against Schistosoma mansoni in infected mice. Int J Dairy Sci 2008; 3(2): 97-104.
[http://dx.doi.org/10.3923/ijds.2008.97.104]
[http://dx.doi.org/10.3923/ijds.2008.97.104]
[25]
El Shenawy NS, Soliman MF, Reyad SI. The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Rev Inst Med Trop São Paulo 2008; 50(1): 29-36.
[http://dx.doi.org/10.1590/S0036-46652008000100007] [PMID: 18327484]
[http://dx.doi.org/10.1590/S0036-46652008000100007] [PMID: 18327484]
[26]
Lescano SZ, Chieffi PP, Canhassi RR, Boulos M, Amato Neto V. Antischistosomal activity of artemether in experimental Schistosomiasis mansoni. Rev Saude Publica 2004; 38(1): 71-5.
[http://dx.doi.org/10.1590/S0034-89102004000100010] [PMID: 14963544]
[http://dx.doi.org/10.1590/S0034-89102004000100010] [PMID: 14963544]
[27]
Hoste H, Torres-Acosta J-F, Alonso-diaz MÁ, Brunet S, Sandoval-Castro C, Adote SH. Identification and validation of bioactive plants for the control of gastrointestinal nematodes in small ruminants. Trop Biomed 2008; 25(1)(Suppl.): 56-72.
[PMID: 18414378]
[PMID: 18414378]
[28]
Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect 1999; 1(2): 125-9.
[http://dx.doi.org/10.1016/S1286-4579(99)80003-3] [PMID: 10594976]
[http://dx.doi.org/10.1016/S1286-4579(99)80003-3] [PMID: 10594976]
[29]
Mantawy MM, Ali HF, Rizk MZ. Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection. Rev Inst Med Trop São Paulo 2011; 53(3): 155-63.
[http://dx.doi.org/10.1590/S0036-46652011000300007] [PMID: 21755238]
[http://dx.doi.org/10.1590/S0036-46652011000300007] [PMID: 21755238]
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