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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

与糖尿病相关的阿尔茨海默病认知测试和脑成像结果之间的差异

卷 19, 期 2, 2022

发表于: 07 March, 2022

页: [95 - 103] 页: 9

弟呕挨: 10.2174/1567205019666220228152655

价格: $65

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摘要

背景：尽管已经对阿尔茨海默病与2型糖尿病之间的关系有了大量的研究调查，但迄今为止与DM有关的AD的隐含病理生理学并未得到完全阐明。我们比较了患有DM的AD患者和未患DM的AD患者的认知功能和脑成像结果来表明患有DM的AD患者的认知功能和脑成像结果之间的关系。 方法：将126位未患有DM的AD患者【AD-DM】和51位患有DM的AD患者【AD+DM】的认知功能和脑成像结果进行比较，包括通过磁共振分析成像的内侧颞叶萎缩和通过单光发射计算机断层扫描的顶叶、后扣带、额区的灌注不足。分析了与认知-成像相关的因素，包括教育、职业、休闲活动、并发症、虚弱程度以及人口统计学。 结果：【AD+DM】组明显地表现出比【AD-DM】组更为严重的认知障碍，尽管二者脑成像结果异常程度类似。在与认知成像相关的因素中，【AD+DM】组休闲活动水平明显低于【AD-DM】。但二者之间的其他因素并未表现出显著差异。 结论：患有DM的AD患者表现出的认知成像差异可能与他们低认知储备有关，可能是由他们休闲活动少造成的。我们的发现表明生活方式的干预，包括身体、认知、社会活动，可能会减少他们认知功能的下降程度。

关键词: 阿尔茨海默病，糖尿病患者，认知，脑成像，认知储备，休闲活动

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