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Current Radiopharmaceuticals

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ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

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Research Article

Application of 68Ga-PSMA-11 PET/CT in the Diagnosis of Prostate Cancer Clinical Relapse

Author(s): Regina Paula Soares Diego*, Gandhi Rádis-Baptista*, Ricardo Vale Albino Oliveira Filho, Estelita Tinoco Branco de Albuquerque, José Daniel Vieira de Castro, Katyane Moreira dos Santos, Joelan Ângelo de Lucena Santos, Guilherme Freire da Silveira Oliveira and Poliane Ângelo de Lucena Santos

Volume 15, Issue 3, 2022

Published on: 01 April, 2022

Page: [228 - 235] Pages: 8

DOI: 10.2174/1874471015666220223100750

Price: $65

Abstract

Background: This work aims to present a nuclear medicine imaging service’s data regarding applying positron emission–computing tomography (PET/CT) scans with the radiopharmaceutical 68Ga-PSMA-HBED-CC (68Ga-PSMA-11) to diagnose prostate cancer clinical relapse.

Methods: Eighty patients with a mean age of 68.26 years and an average prostatic-specific antigen blood level of 7.49 ng/ml (lower concentration = 0.17 ng/ml) received 68Ga-PSMA-11 intravenously, and full-body images of PET-CT scan were obtained. Of the total of patients admitted to the imaging service, 87.5% were examined for disease’s biochemical recurrence and clinical relapse, and 70.0% had a previous radical prostatectomy (RP).

Results: Of the patients without RP, 95.8% were detected with intra-glandular disease. The 68Ga- PSMA-11 PET/CT imaging results revealed small lesions, even in patients with low blood levels of prostatic-specific antigen, mainly in metastatic cancer cases in lymph nodes and bones.

Conclusion: The 68Ga-PSMA-11 PET/CT imaging was essential in detecting prostate cancer, with significantly high sensitivity in detecting recurrent cases. Due to its inherent reliability and sensitivity, PET/CT scanning with 68Ga-PSMA-11 received an increasing number of medical requests throughout the present follow-up study, confirming the augmented demand for this clinical imaging procedure in the regional medical community.

Keywords: 68GA-PSMA-11 PET/CT, radiopharmaceutical, peptide ligand, cancer biomarker, prostate cancer, biochemical recurrence, 68Ga-radiotracer.

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