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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Editorial

The Role of PCSK9 in Atherogenesis and Other Inflammatory Diseases

Author(s): Federico Carbone, Fabrizio Montecucco and Luca Liberale

Volume 29, Issue 6, 2022

Published on: 18 February, 2022

Page: [958 - 959] Pages: 2

DOI: 10.2174/092986732906220218164509

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[1]
Liberale, L.; Montecucco, F.; Schwarz, L.; Lüscher, T.F.; Camici, G.G. Inflammation and cardiovascular diseases: lessons from seminal clinical trials. Cardiovasc. Res., 2021, 117(2), 411-422.
[http://dx.doi.org/10.1093/cvr/cvaa211] [PMID: 32666079]
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Ridker, P.M.; Everett, B.M.; Thuren, T.; MacFadyen, J.G.; Chang, W.H.; Ballantyne, C.; Fonseca, F.; Nicolau, J.; Koenig, W.; Anker, S.D.; Kastelein, J.J.P.; Cornel, J.H.; Pais, P.; Pella, D.; Genest, J.; Cifkova, R.; Lorenzatti, A.; Forster, T.; Kobalava, Z.; Vida-Simiti, L.; Flather, M.; Shimokawa, H.; Ogawa, H.; Dellborg, M.; Rossi, P.R.F.; Troquay, R.P.T.; Libby, P.; Glynn, R.J. CANTOS Trial Group. Anti-inflammatory Therapy with Canakinumab for Atherosclerotic Disease. N. Engl. J. Med., 2017, 377(12), 1119-1131.
[http://dx.doi.org/10.1056/NEJMoa1707914] [PMID: 28845751]
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Ridker, P.M.; MacFadyen, J.G.; Thuren, T.; Everett, B.M.; Libby, P.; Glynn, R.J. CANTOS Trial Group. Effect of interleukin-1beta inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet, 2017, 390(10105), 1833-1842.
[http://dx.doi.org/10.1016/S0140-6736(17)32247-X] [PMID: 28855077]
[5]
Seidah, N.G.; Benjannet, S.; Wickham, L.; Marcinkiewicz, J.; Jasmin, S.B.; Stifani, S.; Basak, A.; Prat, A.; Chretien, M. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc. Natl. Acad. Sci., 2003, 100(3), 928-933.
[http://dx.doi.org/10.1073/pnas.0335507100] [PMID: 12552133]
[6]
Patriki, D. Saeedi, Saravi, S.S.; Camici, G.G.; Liberale, L.; Beer, J.H. PCSK 9: A Link Between Inflammation and Atherosclerosis. Curr. Med. Chem., 2022, 29(2), 251-267.
[http://dx.doi.org/10.2174/0929867328666210707192625] [PMID: 34238141]
[7]
Liberale, L.; Montecucco, F.; Camici, G.G.; Dallegri, F.; Vecchie, A.; Carbone, F.; Bonaventura, A. Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes. Curr. Med. Chem., 2017, 24(14), 1403-1416.
[http://dx.doi.org/10.2174/0929867324666170303123734] [PMID: 28260498]
[8]
Bonaventura, A.; Vecchié, A.; Ruscica, M.; Grossi, F.; Dentali, F. PCSK9 as a new player in cancer: New opportunity or red herring? Curr. Med. Chem., 2022, 29(6), 960-969.
[http://dx.doi.org/10.2174/0929867328666211115122324] [PMID: 34781861]
[9]
Ministrini, S.; Carbone, F. PCSK9 and Inflammation: Their Role in Autoimmune Diseases, with A Focus on Rheumatoid Arthritis and Systemic Lupus Erythematosus. Curr. Med. Chem., 2022, 29(6), 970-979.
[http://dx.doi.org/10.2174/0929867328666210810150940 ] [PMID: 34375179]
[10]
Momtazi-Borojeni, A.A.; Pirro, M.; Xu, S.; Sahebkar, A. PCSK9 inhibition-based therapeutic approaches: an immunotherapy perspective. Curr. Med. Chem., 2022, 29(6), 980-999.
[http://dx.doi.org/10.2174/0929867328666211027125245] [PMID: 34711156]
[11]
Magnasco, L.; Sepulcri, C.; Antonello, R.M.; Di Bella, S.; Labate, L.; Luzzati, R.; Giacobbe, D.R.; Bassetti, M. The role of PCSK9 in infectious diseases. Curr. Med. Chem., 2022, 29(6), 1000-1015.
[http://dx.doi.org/10.2174/0929867328666210714160343] [PMID: 34269657]
[12]
Gencer, B.; Mach, F. PCSK9 inhibition could be effective for acute myocardial infarction. Curr. Med. Chem., 2022, 29(6), 1016-1026.
[http://dx.doi.org/10.2174/0929867328666210804091003] [PMID: 34348606]

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