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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Review of Post-translational Modification of Human Serum Albumin

Author(s): Surya Kannan* and Serhiy Souchelnytskyi

Volume 23, Issue 2, 2022

Published on: 17 March, 2022

Page: [114 - 120] Pages: 7

DOI: 10.2174/1389203723666220217150332

Price: $65

Abstract

Post-translational modifications (PTMs) may affect the functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. This study reviewed one hundred twenty-three recently reported novel O-phosphorylation, glycation, methylation, carbonylation, and acetylation of albumin. Furthermore, the potential impact of these PTMs on albumin functions is discussed. Knowledge of these PTMs of albumin is important for the use of albumin in medical applications, e.g., in transfusion, drug formulations, and remedies.

Keywords: Human serum albumin, post-translational modifications, phosphorylation, glycation, carbonylation, acetylation.

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Graphical Abstract

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