Styrylquinolines Derivatives: SAR Study and Synthetic Approaches

Monika      Saini; Rina      Das; Dinesh   Kumar   Mehta; Samrat      Chauhan
doi:10.2174/1573406418666220214085856
Abstract

In the present-day scenario, heterocyclic derivatives have revealed the primary function of various medicinal agents precious for humanity. Out of a diverse range of heterocycles, Styrylquinolines scaffolds have been proved to play an essential role in a broad range of biological activities, including anti-HIV-1, antimicrobial, anti-inflammatory, anti-Alzheimer activity with antiproliferative effects on tumor cell lines.
Due to the immense pharmacological importance, distinct synthetic methods have been executed to attain new drug entities from Styrylquinolines. Various schemes for synthesizing Styrylquinolines derivatives like one-pot, ultrasound-promoted heterogeneous acid-catalysed, microwave-assisted, solvent-free, and green synthesis were discussed in the present review. Some products of Styrylquinolines are in clinical trials, and patents are also granted for the novel synthesis of Styrylquinolines.
According to the structure-activity relationship, replacement at the R-7 and R-8 positions is required for various activities.
In this review, recent synthetic approaches in the medicinal chemistry of Styrylquinolines and potent Styrylquinolines derivatives based on structural activity relationships (SAR) are outlined. Moreover, their primary methods and modifications are also discussed.
Keywords: Heterocycles, styrylquinolines, SAR study, synthetic schemes, quinoline, styryl moiety.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1573406418666220214085856	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638
Medicinal Chemistry

Styrylquinolines Derivatives: SAR Study and Synthetic Approaches

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