摘要
条件致病菌白色念珠菌的多重耐药(MDR)被定义为对两种或两种以上药物类别中的至少一种药物不敏感。自上世纪末免疫缺陷患者真菌感染发病率上升以来,这一现象得到了越来越多的报道。在发现外排泵过表达是导致念珠菌菌株MDR的主要机制后,针对真菌外排转运体的药物发现产生了越来越大的影响。化学增敏的目的是通过与转运蛋白抑制剂联合治疗提高唑的细胞内浓度。因此,药物外排抑制剂与抗真菌药物联合使用会使病原菌增敏。因此,使用较低的药物浓度将减少对宿主可能产生的不良影响。通过对文献的广泛修订,这篇综述旨在对过去20年开展的关于白念珠菌多药耐药的化学致敏策略的研究提供详尽和批判性的分析。本研究深入分析了戊烯基黄酮类化合物对药物外溢膜转运体的抑制作用,以及这些植物化合物与唑类抗真菌药物的相互作用,作为一种使耐多药白色念珠菌菌株化学敏感的方法。我们强调戊烯类黄酮的重要性及其特殊的化学和药理特性,使其成为具有治疗潜力的化学增敏剂。最后,我们建议对戊烯基黄酮类化合物作为药物外排介导的真菌耐药抑制剂进行进一步的研究。
关键词: 戊烯基类黄酮,抗真菌多药耐药,白色念珠菌,ABC转运体,MFS转运体,构效关系。
Current Medicinal Chemistry
Title:A State-of-the-art Review and Prospective Therapeutic Applications of Prenyl Flavonoids as Chemosensitizers against Antifungal Multidrug Resistance in Candida albicans
Volume: 29 Issue: 24
关键词: 戊烯基类黄酮,抗真菌多药耐药,白色念珠菌,ABC转运体,MFS转运体,构效关系。
摘要:
Multidrug resistance (MDR) in the opportunistic pathogen Candida albicans is defined as non-susceptibility to at least one agent in two or more drug classes. This phenomenon has been increasingly reported since the rise in the incidence of fungal infections in immunocompromised patients at the end of the last century.
After the discovery of efflux pump overexpression as a principal mechanism causing MDR in Candida strains, drug discovery targeting fungal efflux transporters has had a growing impact. Chemosensitization aims to enhance azole intracellular concentrations through combination therapy with transporter inhibitors. Consequently, the use of drug efflux inhibitors combined with the antifungal agent will sensitize the pathogen. As a result, the use of lower drug concentrations will reduce possible adverse effects on the host.
Through an extensive revision of the literature, this review aims to provide an exhaustive and critical analysis of the studies carried out in the past two decades regarding the chemosensitization strategy to cope with multidrug resistance in C. albicans. This work provides a deep analysis of the research on the inhibition of drug-efflux membrane transporters by prenylated flavonoids and the interactions of these phytocompounds with azole antifungals as an approach to chemosensitize multidrug-resistant C. albicans strains. We highlight the importance of prenylflavonoids and their particular chemical and pharmacological characteristics that make them excellent candidates with therapeutic potential as chemosensitizers. Finally, we propose the need for further research on prenyl flavonoids as inhibitors of drug-efflux mediated fungal resistance.
Export Options
About this article
Cite this article as:
A State-of-the-art Review and Prospective Therapeutic Applications of Prenyl Flavonoids as Chemosensitizers against Antifungal Multidrug Resistance in Candida albicans, Current Medicinal Chemistry 2022; 29 (24) . https://dx.doi.org/10.2174/0929867329666220209103538
DOI https://dx.doi.org/10.2174/0929867329666220209103538 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Withdrawal Notice: Synergistic Effect of Myricetin and Phenolic Acid Derivatives on the Reversal of Dengue Fever Related Thrombocytopenia and its Pharmacokinetics study in Plasma by using HPLC and UPLC-Q-TOF
Current Drug Metabolism Modification of Decoy Oligodeoxynucleotides to Achieve the Stability and Therapeutic Efficacy
Current Topics in Medicinal Chemistry Protein-Modified Magnetic Nanoparticles for Biomedical Applications
Current Organic Chemistry Electrochemical DNA Sensors: From Nanoconstruction to Biosensing
Current Organic Chemistry Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives
Medicinal Chemistry Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells
Recent Patents on Anti-Cancer Drug Discovery Pharmacokinetics, Organ Toxicity and Antitumor Activity of Docetaxel Loaded in Folate Targeted Cholesterol Based Micelles
Current Drug Delivery Aptamer-Targeted Oligonucleotide Theranostics: A Smarter Approach for Brain Delivery and the Treatment of Neurological Diseases
Current Topics in Medicinal Chemistry Detoxification of Aflatoxin M1 (AFM1) in Dairy Base Beverages (Acidophilus Milk) by Using Different Types of Lactic Acid Bacteria-Mini Review
Current Nutrition & Food Science New Antioxidant Source: Matricaria chamomilla
Current Bioactive Compounds Nanotechnology Advancements in the Diagnosis and Prevention of COVID-19: Past and Future
Coronaviruses Optimization and Analysis of Acid Treated Trimethylamine using Surface Response and Gas Chromatography Analytical Methods
Current Analytical Chemistry A Novel Trypsin and α-Chymotrypsin Inhibitor from Maclura pomifera Seeds
Letters in Drug Design & Discovery Preoperative Functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS)
Current Medical Imaging Review of Rational Approaches to the Treatment of Pain Management-Role forOpioids Therapies
Current Drug Therapy Nanoplatforms for Promoting Osteogenesis in Ovariectomy-Induced Osteoporosis in the Experimental Model
Current Nanomedicine Template Synthesis of Tubular Nanostructures for Loading Biologically Active Molecules
Current Topics in Medicinal Chemistry Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Glioma Dynamics and Computational Models: A Review of Segmentation, Registration, and In Silico Growth Algorithms and their Clinical Applications
Current Medical Imaging The Salivary miRNome: A Promising Biomarker of Disease
MicroRNA