Palladium-Catalysed Intermolecular Direct C–H Bond Arylation of Heteroarenes
with Reagents Alternative to Aryl Halides: Current State of the Art

Renzo      Rossi; Maurizio      Ciofalo
doi:10.2174/1385272826666220201124008
Abstract

This unprecedented review with 322 references provides a critical up-to-date picture of the Pd-catalysed intermolecular direct C–H bond arylation of heteroarenes with arylating reagents alternative to aryl halides that include aryl sulfonates (aryl triflates, tosylates, mesylates, and imidazole- 1-sulfonates), diaryliodonium salts, [(diacetoxy)iodo]arenes, arenediazonium salts, 1-aryltriazenes, arylhydrazines and N’-arylhydrazides, arenesulfonyl chlorides, sodium arenesulfinates, arenesulfinic acids, and arenesulfonohydrazides. Particular attention has been paid to summarise the preparation of the various arylating reagents and to highlight the practicality, versatility, and limitations of the various developed arylation protocols, also comparing their results with those achieved in analogous Pd-catalysed arylation reactions involving the use of aryl halides as electrophiles. Mechanistic proposals have also been briefly summarised and discussed. However, data concerning Pd-catalysed direct C–H bond arylations involving the C–H bonds of aryl substituents of the examined heteroarene derivatives have not been taken into account.
Keywords: Heteroarenes, palladium, direct C–H bond arylation, catalysis, regioselectivity, aryl halides.
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DOI https://dx.doi.org/10.2174/1385272826666220201124008	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

Palladium-Catalysed Intermolecular Direct C–H Bond Arylation of Heteroarenes with Reagents Alternative to Aryl Halides: Current State of the Art

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

Current Organic Chemistry

Palladium-Catalysed Intermolecular Direct C–H Bond Arylation of Heteroarenes with Reagents Alternative to Aryl Halides: Current State of the Art

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

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