Abstract
Gastric cancer (GC) is the leading cause of death and cancer mortality in the world, with poor survival for cases with higher stages of GC. During the past decade, GC stem cells (GCSCs), a group of cancer cells, have been the focus of significant research on cancer. GCSCs have the capability of selfrenewal and are identified to participate in GC development, invasion, chemoresistance, and tumor relapse. Research projects have indicated the main activities of noncoding RNAs in cellular pathways. Micro (mi)RNAs and lncRNAs play important functions in the modulation of different cellular pathways in the post-transcriptional form through their dysregulated expression in several cancers, including GC. In this paper, we highlight the impact of dysregulated expression of micro- and lncRNAs and their downstream transcripts on GCSCs. Data collection on the progression of GCSCs may be beneficial for the introduction of new insights to the GC treatment.
Keywords: Gastric cancer, non-coding RNAs, stem cells, cancer treatment, miRNAs, lncRNAs.
Graphical Abstract
[http://dx.doi.org/10.1093/femspd/ftz039] [PMID: 31351000]
[http://dx.doi.org/10.1093/femspd/ftaa004] [PMID: 31981356]
[http://dx.doi.org/10.1177/1010428317701652] [PMID: 28468587] ; (b) Pourmahdi M, Saber A, Rajabi A, Abdolahi S, Ebrahimi P, Safaralizadeh R. Key epigenetic events involved in the maintenance of breast cancer stem cells. Curr Stem Cell Res Ther 2021; 16(7): 877-87.
[http://dx.doi.org/10.2174/1574888X16666210203111605] [PMID: 33563177]
[http://dx.doi.org/10.3390/cells8080840] [PMID: 31530793]
[http://dx.doi.org/10.4103/jomfp.JOMFP_132_16] [PMID: 29391738]
[http://dx.doi.org/10.1016/j.ejca.2017.07.020] [PMID: 28822889]
[http://dx.doi.org/10.3349/ymj.2018.59.10.1150] [PMID: 30450848]
[http://dx.doi.org/10.1038/onc.2013.492] [PMID: 24240682] ; (b) Hui Y, Yang Y, Li D, et al. LncRNA FEZF1-AS1 modulates cancer stem cell properties of human gastric cancer through miR- 363-3p/HMGA2. Cell Transplant 2020; 29: 963689720925059.
[http://dx.doi.org/10.1177/0963689720925059] [PMID: 32638620] ; (c) Behzadi S, Baradaran B, Hosseinpourfeizi MA, et al. BC032913 as a novel antisense non-coding RNA is downregulated in gastric cancer. J Gastrointest Cancer 2021; 53(2): 928-31.
[PMID: 32914372] ; (d) Mohammadzadeh A, Baradaran B, Dastmalchi N, Hashemzadeh S, Safaralizadeh R. The correlation between helicobacter pylori infection and lnc-oc1 expression in gastric cancer tissues in an iranian population. J Gastrointest Cancer 2021; 52(2): 600-5.
[http://dx.doi.org/10.1007/s12029-020-00438-4] [PMID: 32529394] ; (e) Azarbarzin S, Safaralizadeh R, Khojasteh MB, Baghbanzadeh A, Baradaran B. Current perspectives on the dysregulated microRNAs in gastric cancer. Mol Biol Rep 2020; 47(9): 7253-64.
[http://dx.doi.org/10.1007/s11033-020-05720-z] [PMID: 32776162] ; (f) Azarbarzin S, Hosseinpour Feizi MA, Safaralizadeh R, et al. The Value of miR-299-5p in diagnosis and prognosis of intestinal-type gastric adenocarcinoma. Biochem Genet 2016; 54(4): 413-20.
[http://dx.doi.org/10.1007/s10528-016-9728-y] [PMID: 27007598]
[http://dx.doi.org/10.1007/s13402-020-00560-2] [PMID: 32930970] ; (b) Ruggieri V, Russi S, Zoppoli P, et al. The role of MicroRNAs in the regulation of gastric cancer stem cells: A meta-analysis of the cur-rent status. J Clin Med 2019; 8(5): E639.
[http://dx.doi.org/10.3390/jcm8050639] [PMID: 31075910]
[http://dx.doi.org/10.1016/j.canlet.2020.02.040] [PMID: 32142918]
[http://dx.doi.org/10.1002/jcp.29168] [PMID: 31517391]
[http://dx.doi.org/10.1111/jgh.14649] [PMID: 30843262]
[http://dx.doi.org/10.3892/or.2017.5831] [PMID: 28731132]
[http://dx.doi.org/10.1016/j.lfs.2021.119222] [PMID: 33609542]
[http://dx.doi.org/10.1158/1078-0432.CCR-10-2132] [PMID: 21220473]
[http://dx.doi.org/10.1186/s13046-016-0432-x] [PMID: 27846906]
[http://dx.doi.org/10.7150/ijms.21164] [PMID: 29333091]
[http://dx.doi.org/10.1002/mc.22656] [PMID: 28383763]
[http://dx.doi.org/10.3892/ijo.2017.3965] [PMID: 28440445]
[http://dx.doi.org/10.2147/CMAR.S231369] [PMID: 31849528]
[http://dx.doi.org/10.1111/cpr.12687] [PMID: 31468594]
[http://dx.doi.org/10.1111/jcmm.15161] [PMID: 32160650]
[http://dx.doi.org/10.1038/s41388-019-0747-0] [PMID: 30742067]
[http://dx.doi.org/10.1038/s41419-020-2426-z] [PMID: 32300102]
[http://dx.doi.org/10.1089/cell.2016.0001] [PMID: 27602437]
[http://dx.doi.org/10.1007/s11523-020-00717-x] [PMID: 32451752]
[http://dx.doi.org/10.1038/nrd4140] [PMID: 24172333]
[http://dx.doi.org/10.1007/s13402-018-0406-4] [PMID: 30218296]
[http://dx.doi.org/10.2147/CMAR.S279978] [PMID: 33273858]
[http://dx.doi.org/10.1186/s12943-020-01219-0] [PMID: 32460771]
[http://dx.doi.org/10.3390/cancers13071587] [PMID: 33808190]