Label-Free Cell-Based Assays for GPCR Screening

Title: Label-Free Cell-Based Assays for GPCR Screening

Volume: 11 Issue: 5

Author(s): Ye Fang*, Anthony G. Frutos and Ronald Verklereen

Affiliation:

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Keywords: G protein-coupled receptor, optical biosensor, resonant waveguide grating biosensor, electrical biosensor, dynamic mass redistribution, impedance, high throughput screening

Abstract: G protein-coupled receptors (GPCRs) have been proven to be the largest family of druggable targets in the human genome. Given the importance of GPCRs as drug targets and the de-orphanization of novel targets, GPCRs are likely to remain the frequent targets of many drug discovery programs. With recent advances in instrumentation and understanding of cellular mechanisms for the signals measured, biosensor-centered label-free cell assay technologies become a very active area for GPCR screening. This article reviews the principles and potential of current label-free cell assay technologies in GPCR drug discovery.

Cite this article as:

Fang Ye*, Frutos G. Anthony and Verklereen Ronald, Label-Free Cell-Based Assays for GPCR Screening, Combinatorial Chemistry & High Throughput Screening 2008; 11 (5) . https://dx.doi.org/10.2174/138620708784534789