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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

胃肠胰神经内分泌肿瘤 (GEP NENs)：检查点抑制剂的作用

卷 22, 期 8, 2022

发表于: 21 April, 2022

页: [629 - 638] 页: 10

弟呕挨: 10.2174/1568009622666220114124335

价格: $65

摘要

背景：GEP-NENs 的治疗选择包括多种药物，并且基于分级、形态和原发灶位置。 目的：我们工作的目的是研究新的免疫检查点抑制剂的临床影响，以确定在 GEP-NEN 中使用的新策略。 方法：使用 PubMed 和 Embase 进行 2015 年至 2020 年 1 月的科学文献检索：选择至少 20 名患者的评论和前瞻性或回顾性研究；包括会议记录。 结果：已经进行了几项研究来评估免疫检查点抑制剂在 NENs 中的作用，但如今，该领域的当前知识主要基于 I-II 期研究。免疫疗法显示出有限的抗肿瘤活性，但在分化差的神经内分泌肿瘤中报道了更高的反应率。没有确定用于患者选择和反应评估的特定生物标志物。 结论：免疫疗法似乎是帮助我们患者的一种强有力的可能性，但如今，我们在该领域看到了许多空白。我们必须在精准肿瘤学提供的治疗可能性与了解临床实践中检测和治疗应用的局限性之间取得平衡。未来的努力应该集中在研究最适合免疫治疗的患者，包括疾病特征和先前的治疗方法，以及如何选择具有准确生物标志物的患者。

关键词: 胃肠胰、神经内分泌、肿瘤、检查点抑制剂、免疫治疗、PD-L1。

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