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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

The Advances in Bioactivities, Mechanisms of Action and Structural Optimizations of Matrine and its Derivatives

Author(s): Jianwei Xu, Min Lv* and Hui Xu*

Volume 22, Issue 13, 2022

Published on: 25 February, 2022

Page: [1716 - 1734] Pages: 19

DOI: 10.2174/1389557522666220113124717

Price: $65

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Abstract

Matrine, a tetracyclo-quinolizidine alkaloid, is isolated from the industrial crop plant Sophora flavescens. Due to a wide range of pharmacological and agricultural properties, the research on the phytochemistry, pharmacology, toxicology, and mechanisms of action of matrine and its derivatives has received much attention. On the other hand, to improve their biological activities, the study on structural optimizations and structure-activity relationships of matrine and its derivatives has also attached more and more importance. In this review article, the updates regarding the advances in bioactivities, mechanisms of action, structural modifications, and structure-activity relationships of matrine and its derivatives from 2017 to 2020 are presented. We hope that this review will provide a reference for the development and application of matrine and its derivatives as drugs or pesticides in the future.

Keywords: Matrine, structural modification, biological activity, mechanism of action, structure-activity relationship, pesticide.

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Graphical Abstract

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