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Current Radiopharmaceuticals

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ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

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Research Article

Usefulness of 99mTc-Pertechnetate SPECT-CT in Thyroid Tissue Volumetry: Phantom Studies and a Clinical Case Series

Author(s): Enrico Calandri*, Maria Teresa Giraudo, Roberta Sirovich, Antonella Ostan, Mirco Pultrone, Viviana Frantellizzi, Lucia Conversano, Paolo Bagnasacco, Sonya Gallina and Giuseppe De Vincentis

Volume 15, Issue 3, 2022

Published on: 26 April, 2022

Page: [205 - 217] Pages: 13

DOI: 10.2174/1874471015666220111145550

Price: $65

Abstract

Background: An accurate measurement of the target volume is of primary importance in theragnostics of hyperthyroidism.

Objective: Our purpose was to evaluate the accuracy of a threshold-based isocontour extraction procedure for thyroid tissue volumetry from SPECT-CT.

Methods: Cylindrical vials with a fixed volume of 99mTcO4 at different activities were inserted into a neck phantom in two different thickness settings. Images were acquired by orienting the phantom in different positions, i.e., 40 planar images and 40 SPECT-CT. The fixed values of the isocontouring threshold for SPECT and SPECT-CT were calculated by means of linear and spline regression models. Mean, Median, Standard Deviation, Standard Error, Mean Absolute Percentage Error and Root Mean-Square Error were computed. Any difference between the planar method, SPECT and SPECT-CT and the effective volume was evaluated by means of ANOVA and posthoc tests. Moreover, planar and SPECT-CT acquisitions were performed in 8 patients with hyperthyroidism, considering relevant percentage differences greater than > 20% from the CT gold standard.

Results: Concerning phantom studies, the planar method shows higher values of each parameter than the other two methods. SPECT-CT shows lower variability. However, no significant differences were observed between SPECT and SPECT-CT measurements. In patients, relevant differences were found in 7 out of 9 lesions with the planar method, in 6 lesions with SPECT, but in only one with SPECT-CT.

Conclusion: Our study confirms the superiority of SPECT in volume measurement if compared with the planar method. A more accurate measurement can be obtained from SPECT-CT.

Keywords: Thyroid, hyperthyroidism, thyroid tissue volumetry, SPECT, SPECT-CT, theragnostics.

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Graphical Abstract

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