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Protein & Peptide Letters

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ISSN (Online): 1875-5305

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Mini-Review Article

Aminoacyl-tRNA Synthetases, Indispensable Players in Lung Tumorigenesis

Author(s): Pratyasha Bhowal, Priyanka Biswas Karmakar, Debkanya Dey, Riya Manna, Debraj Roy and Rajat Banerjee*

Volume 29, Issue 3, 2022

Published on: 15 March, 2022

Page: [208 - 217] Pages: 10

DOI: 10.2174/0929866529666220110143520

Price: $65

Abstract

Being an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered altered expressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs), forming a multi-tRNA synthetase complex (MSC) and divulging into their roles outside the range of protein synthesis. In this review, we have directed our focus into the rudimentary structure of this compact association and also how these aaRSs and AIMPs are involved in the maintenance and progression of lung cancer, the principal cause of most cancer-related deaths. There is substantial validation that suggests the crucial role of these prime housekeeping proteins in lung cancer regulation. Here, we have addressed the biological role that the three AIMPs and the aaRSs play in tumorigenesis, along with an outline of the different molecular mechanisms involved in the same. In conclusion, we have introduced the potentiality of these components as possible therapeutics for the evolution of new-age treatments of lung tumorigenesis.

Keywords: Aminoacyl-tRNA synthetases (aaRSs), AIMPs, MSC, lung cancer, signal pathways, inhibitors.

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