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Review Article

microRNAs的临床前作用及其对结直肠癌的贡献的最新综述

卷 22, 期 10, 2022

发表于: 12 January, 2022

页: [851 - 859] 页: 9

弟呕挨: 10.2174/1566524021666211213122619

价格: $65

摘要

结直肠癌（CRC）是全球恶性肿瘤相关死亡的主要原因之一。 众所周知，microRNAs （miRNAs） 决定性地参与细胞生物学通路。 在某种程度上，miRNAs的失调表达会导致 CRC 进展。 miRNA 可以通过与参与不同生物过程的各种分子靶标结合来控制 mRNAs的翻译和降解，包括生长、凋亡、细胞周期、自噬、血管生成、转移等。这些失调的 miRNAs 的功能可能是致癌的或抑癌的。 因此，这些 miRNAs 可用于 CRC 的预后、诊断和治疗方法。 在这项研究中，我们回顾了 miRNA 在 CRC 中的肿瘤抑制和致癌功能，并评估了其在 CRC 发展中的分子活性。 然而，需要进一步研究失调的 miRNA 在 CRC 进展中的作用。

关键词: 结直肠癌，MicroRNA，分子功能，生物途径，化疗，白藜芦醇。

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