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Review Article

鞘脂和溶血磷脂酸对肿瘤免疫微环境的调节作用

卷 23, 期 6, 2022

发表于: 14 January, 2022

页: [559 - 573] 页: 15

弟呕挨: 10.2174/1389450122666211208111833

价格: $65

摘要

肿瘤微环境（TME）由癌细胞组成，癌细胞与细胞外基质、血液和淋巴网络、成纤维细胞、脂肪细胞和免疫系统细胞等基质成分相互作用。此外，以肿瘤浸润性免疫细胞（TIIC）为代表的肿瘤免疫微环境在肿瘤治疗和患者预后中发挥着重要作用。事实上，众所周知，在肿瘤微环境中高密度的TIICs与几种类型的癌症的更好的治疗效果有关。为此，两种生物活性脂质分子，溶血磷脂酸（LPA）和鞘氨醇-1-磷酸（S1P），调节免疫细胞对TME的归位。本文将揭示LPA和S1P信号通路在肿瘤免疫环境中的作用，重点介绍这一领域的最新进展。

关键词: 肿瘤微环境，肿瘤浸润免疫细胞，肿瘤浸润淋巴细胞，鞘氨醇-1-磷酸，溶血磷脂酸，免疫系统。

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