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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Author(s): Cauê Benito Scarim * and Chung Man Chin

Volume 22, Issue 12, 2022

Published on: 01 February, 2022

Page: [2204 - 2240] Pages: 37

DOI: 10.2174/1871520621666211201152815

Price: $65

Abstract

Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment of several illnesses, including cancers. In this review article, we have demonstrated various studies involving these three pharmacophore classes (thiazoles, triazoles, and thiosemicarbazones) in medicinal chemistry over the last decade (2011-2021) with a focus on MCF-7 adenocarcinoma breast cancer cells. Our objective is to facilitate drug discovery of novel chemotherapeutic agents by detailing anti-proliferative compounds.

Keywords: Thiazoles, triazoles, thiosemicarbazones, anti-proliferative, breast cancer, MCF-7.

Graphical Abstract

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