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Review Article

PCSK9 作为癌症新型选手：新机遇还是无关紧要？

卷 29, 期 6, 2022

发表于: 14 January, 2022

页: [960 - 969] 页: 10

弟呕挨: 10.2174/0929867328666211115122324

价格: $65

摘要

最初被描述为参与肝再生和神经元分化的因子，前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 已成为低密度脂蛋白胆固醇的关键调节因子之一。除此之外，许多研究表明 PCSK9 可能在癌症生物学中发挥作用。对于肠胃癌（胃癌和肝癌）和肺癌尤其如此，其中较高的 PCSK9 水平与肿瘤发展和转移的能力增加以及总体存活率降低有关。因此，最近显示阻断 PCSK9 的单克隆抗体与不同类型癌症的免疫疗法协同作用，通过增加细胞毒性 T 细胞的肿瘤内浸润来实现肿瘤生长抑制。抗 PCSK9 疫苗已在动物模型中进行了测试，仅在结肠癌中取得了令人鼓舞的结果。由于这些证据大部分是基于临床前研究，这导致了一些争议和不一致，因此表明需要进一步的研究来澄清这个话题。最后，通过沉默 RNA (siRNA) 调节细胞内 PCSK9 水平可能有助于了解 PCSK9 的生理和病理机制。

关键词: PCSK9、癌症、胆固醇、免疫疗法、疫苗、疗法

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