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Review Article

人类癌症中非编码RNA编码的肽/蛋白：癌症治疗的未来

卷 29, 期 22, 2022

发表于: 14 January, 2022

页: [3819 - 3835] 页: 17

弟呕挨: 10.2174/0929867328666211111163701

价格: $65

摘要

虽然非编码RNA（non-coding RNAs，ncRNAs）最初被认为是一类没有编码能力的RNA转录物，但已经证实的是， 一些非编码RNA （ncRNAs）实际上包含开放阅读框（open reading frames，ORF），可以翻译成微肽或微蛋白。最近的研究表明，ncRNAs衍生的微肽/微蛋白对各种生物和肿瘤过程具有调节功能。其中一些微肽/微蛋白起到肿瘤抑制剂的作用，另一些则起到肿瘤诱导剂的作用。了解 ncRNAs编码的微肽/微蛋白的致癌作用可能会给癌症研究带来了潜在的挑战，并为癌症治疗提供了实用前景。在这篇综述中，我们总结了ncRNAs衍生的微肽/微蛋白与人类不同类型的癌症相关的现有信息。我们还提到了它们在癌症代谢、信号通路、细胞增殖、血管生成、癌转移等方面的致癌机制。最后，我们论述了这些微肽/微蛋白的潜在临床价值及其在癌症诊断和治疗中的应用。这些信息可能有助于我们发现、优化和开发基于生物微肽/微蛋白的新方法，用于早期诊断和开发抗癌药物。

关键词: 癌症，微肽，微蛋白，非编码RNA （NcRNAs），长链非编码RNA（LncRNAs），环状RNA（CircRNAs），MiRNAs

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