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Review Article

5′-脱氧核苷磷酸酯类似物的合成研究进展

卷 29, 期 22, 2022

发表于: 17 January, 2022

页: [3857 - 3921] 页: 65

弟呕挨: 10.2174/0929867328666211111162447

价格: $65

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摘要

本文主要论述了环5′-脱氧核苷磷酸酯类似物的合成。各种磷酸烷基部分的形成通过以下反应实现的： (i)Wittig（或HWE）缩合到核苷醛部分； (ii)使用膦酸根阴离子或路易斯酸进行亲核置换反应； (iii)Arbuzov反应； (iv)乙烯基膦酸盐和乙烯基化核苷之间的烯烃交叉复分解； (v)由基反应和钯催化炔烃 对于核酸碱基与环部分的偶联，通常采用Mitsunobu反应和Sonogashira型交叉偶联。对于呋喃糖部分与碱基的偶联，通常采用Vorbruggentype缩合。硒离子介导的加成反应主要用于碳环部分的偶联。在此我们总结了它们的生物活性结果。。

关键词: 5′-脱氧核苷磷酸盐，抗病毒药物，酶抑制剂，生物电子等排体，核苷，核苷类似物

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