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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Research Article

Ternary System of Bacogenins with Fulvic Acid and Hydrogenated Soy Lecithin: Preparation, Characterization and, In vivo Studies

Author(s): Kattamanchi Gnananath, Kalakonda Sri Nataraj*, Battu Ganga Rao, Kolli Prabhanjan Kumar, Kommavari Chandrasekhar, Pooja Jain and Mohd. Aamir Mirza*

Volume 22, Issue 23, 2022

Published on: 30 November, 2021

Page: [1966 - 1978] Pages: 13

DOI: 10.2174/1568026621666211111155425

Price: $65

Abstract

Aims: The aim of this study was to simultaneously enhance the solubility and stability of bacogenins hydrolyzed bacoside rich extract by a ternary system comprised of hydrogenated soy lecithin and a third auxiliary substance, fulvic acid.

Methods: Both ternary and binary complexes were prepared using the solvent evaporation method were characterized by Fourier transform infrared technique, differential scanning calorimeter and scanning electron microscope. The entrapment efficacy in both binary and ternary system was calculated and the effect on the solubility, dissolution and stability of bacogenins was found out. Furthermore, the prepared complexes were subjected to behavioural pharmacological studies.

Results: FTIR, DSC, and SEM studies in totality confirmed the formation of binary and ternary complexes. Enhancement in solubility was observed, and the order of release characteristics was found to be BHFS> BHSL>BHF> BH when the dissolution studies were carried out in 40% aqueous solution of ethanol. A significant improvement in the memory and antioxidant capacity was noticed in both binary, ternary complexes and fulvic acid treatment groups.

Conclusion: The results revealed that the ternary complex could be a promising drug delivery system to improve the oral bioavailability of the bacogenins.

Keywords: Bacopa monnieri aglycones, Ebelin lactone, Auxiliary substance, Phospholipid complex, Memory enhancement, Supramolecular assembly.

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