Mutual Effects of Free and Nanoencapsulated Phenolic Compounds
on Human Microbiota

Carina       Cassini; Pedro    Henrique    Zatti; Valéria    Weiss    Angeli; Catia    Santos    Branco; Mirian       Salvador
doi:10.2174/0929867328666211101095131
Abstract

Phenolic compounds (PC) have many health benefits such as antioxidant, anticarcinogenic, neuroprotective, and anti-inflammatory activities. All of these activities depend on their chemical structures and their interaction with biological targets in the body. PC occur naturally in polymerized form, linked to glycosides and require metabolic transformation from their ingestion to their absorption. The gut microbiota can transform PC into more easily absorbed metabolites. PC, in turn, have prebiotic and antimicrobial actions on the microbiota. Despite this, their low oral bioavailability still compromises biological performance. Therefore, the use of nanocarriers has been demonstrated to be a useful strategy to improve PC absorption and, consequently, their health effects. Nanotechnology is an excellent alternative able to overcome the limits of oral bioavailability of PC, since it offers protection from degradation during their passage through the gastrointestinal tract. Moreover, nanotechnology is also capable of promoting controlled PC release and modulating the interaction between PC and the microbiota. However, little is known about the impact of nanotechnology on PC effects on the gut microbiota. This review highlights the use of nanotechnology for PC delivery on gut microbiota, focusing on the ability of such formulations to enhance oral bioavailability by applying nanocarriers (polymeric nanoparticles, nanostructured lipid carriers, solid lipid nanoparticles). In addition, the effects of free and nanocarried PC or nanocarriers per se on gut microbiota are also described.
Keywords: Phenolic compounds, gut microbiota, nanotechnology, mutual effects, bioavailability, dysbiosis.
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DOI https://dx.doi.org/10.2174/0929867328666211101095131	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

Mutual Effects of Free and Nanoencapsulated Phenolic Compounds on Human Microbiota

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