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Current Women`s Health Reviews

Editor-in-Chief

ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Systematic Review Article

The Association between Maternal COVID-19 and the Rates of Cesarean: A Systematic Review

Author(s): Ensiyeh Jenabi , Seyedeh Zahra Masoumi, Mansoureh Refaei, Niloofar Ladoni and Sargol Shafiei *

Volume 18, Issue 4, 2022

Published on: 07 January, 2022

Article ID: e271021197411 Pages: 5

DOI: 10.2174/1573404817666211027093445

Price: $65

Abstract

Background: Maternal COVID-19 infection has been reported to be associated with an increase in the rates of C-sections. However, studies have not reported this association consistently. Therefore, this systematic review and meta-analysis were conducted regarding this issue.

Methods: We identified all publications up to January 2021 in databases of PubMed, Scopus, and Web of Science. In addition, we reviewed gray literature and conference proceedings. The pooled odds ratios (OR) and 95% confidence intervals (CI) measured from eligible studies were used as random effect estimates of association among studies. Heterogeneity testing using I2 statistics was performed to assess variance between the studies.

Results: The pooled estimates of OR did not report a significant association between COVID-19 and the risk of cesarean section, respectively (OR = 2.02, 95% CI = 0. 4 to 3.64). There was low heterogeneity among the studies reporting the risk of diseases associated with cesarean section among children based on OR (I2=12.7%, P=0.333). The P-values for Begg’s and Eggerʼs regression were 0.573 and 0.555, respectively.

Conclusion: While we did not find an association between COVID-19 and increased rates of cesarean sections, we cannot exclude a type II error; therefore, additional studies, including large cohort studies by controlling confounding variables, should be performed in the future.

Keywords: Coronavirus, cesarean section, meta-analysis, statistics, pregnanat women, COVID-19 ifection.

Graphical Abstract

[1]
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727-33.
[http://dx.doi.org/10.1056/NEJMoa2001017] [PMID: 31978945]
[2]
Influenza W. COVID-19-similarities and differences. World Health Organization 2020. Available from: https://www. who. int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/qa-detail/qa-similarities-and-differences- covid-19-and-influenza Published, 2020.
[3]
Yu N, Li W, Kang Q, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. Lancet Infect Dis 2020; 20(5): 559-64.
[http://dx.doi.org/10.1016/S1473-3099(20)30176-6] [PMID: 32220284]
[4]
Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med 2020; 144(7): 799-805.
[http://dx.doi.org/10.5858/arpa.2020-0901-SA] [PMID: 32180426]
[5]
Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395(10226): 809-15.
[http://dx.doi.org/10.1016/S0140-6736(20)30360-3] [PMID: 32151335]
[6]
Liu D, Li L, Wu X, et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A preliminary analysis. AJR Am J Roentgenol 2020; 215(1): 127-32.
[http://dx.doi.org/10.2214/AJR.20.23072] [PMID: 32186894]
[7]
Nikpour M. Pregnancy outcomes and clinical manifestations of Covid-19 in pregnant women: A narrative review. J Mil Med 2020; 22(2): 177-83.
[8]
Jenabi E. Pregnancy outcomes in pregnant women infected with COVID-19: A cohort study. Hamadan Universiy of Medical Sciences 2021.
[9]
Li N, Han L, Peng M, et al. Maternal and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) pneumonia: A case-control study. Clin Infect Dis 2020; 71(16): 2035-41.
[http://dx.doi.org/10.1093/cid/ciaa352] [PMID: 32249918]
[10]
Sun G, Zhang Y, Liao Q, Cheng Y. Blood test results of pregnant COVID-19 patients: An updated case-control study. Front Cell Infect Microbiol 2020; 10: 560899.
[http://dx.doi.org/10.3389/fcimb.2020.560899] [PMID: 33117727]
[11]
Yang H, Sun G, Tang F, et al. Clinical features and outcomes of pregnant women suspected of coronavirus disease 2019. J Infect 2020; 81(1): e40-4.
[http://dx.doi.org/10.1016/j.jinf.2020.04.003] [PMID: 32294503]
[12]
Wells GA. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2009.
[13]
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109): 629-34.
[http://dx.doi.org/10.1136/bmj.315.7109.629] [PMID: 9310563]
[14]
Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr 2020; 174(7): 722-5.
[http://dx.doi.org/10.1001/jamapediatrics.2020.0878] [PMID: 32215598]
[15]
Liao J, He X, Gong Q, Yang L, Zhou C, Li J. Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic. Int J Gynaecol Obstet 2020; 150(1): 53-7.
[http://dx.doi.org/10.1002/ijgo.13188] [PMID: 32350871]
[16]
Papapanou M, Papaioannou M, Petta A, et al. Maternal and neonatal characteristics and outcomes of COVID-19 in pregnancy: An overview of systematic reviews. Int J Environ Res Public Health 2021; 18(2): 596.
[http://dx.doi.org/10.3390/ijerph18020596] [PMID: 33445657]
[17]
Poon LC, Yang H, Kapur A, et al. Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. Int J Gynaecol Obstet 2020; 149(3): 273-86.
[http://dx.doi.org/10.1002/ijgo.13156] [PMID: 32248521]
[18]
Jenabi E, Bashirian S, Khazaei S, et al. Pregnancy outcomes among symptomatic and asymptomatic women infected with COVID-19 in the west of Iran: A case-control study. J Matern Fetal Neonatal Med 2020; 1-3.
[http://dx.doi.org/10.1080/14767058.2020.1861599] [PMID: 33322959]
[19]
Zhang L, Jiang Y, Wei M, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi 2020; 55(3): 166-71. [Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province].
[PMID: 32145714]
[20]
Boelig RC, Manuck T, Oliver EA, et al. Labor and delivery guidance for COVID-19. Am J Obstet Gynecol MFM 2020; 2(2): 100110.
[http://dx.doi.org/10.1016/j.ajogmf.2020.100110] [PMID: 32518901]
[21]
Walker KF, O’Donoghue K, Grace N, et al. Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: A systematic review and critical analysis. BJOG 2020; 127(11): 1324-36.
[http://dx.doi.org/10.1111/1471-0528.16362] [PMID: 32531146]
[22]
Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVID-19) and pregnancy: A systematic review. J Matern Fetal Neonatal Med 2020; 1-4.
[http://dx.doi.org/10.1080/14767058.2020.1759541] [PMID: 32354293]

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