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Mini-Review Article

KIR和HLA的相互作用会影响非感染性葡萄膜炎的发展吗？

卷 22, 期 8, 2022

发表于: 21 December, 2021

页: [703 - 716] 页: 14

弟呕挨: 10.2174/1566524021666211027092124

open access plus

摘要

在眼睛中建立免疫耐受性，以防止与免疫细胞浸润引起的角膜和视网膜破坏性损伤相关的永久性失明；因此，免疫反应和随后的炎症被强烈抑制。虽然非感染性葡萄膜炎是由眼部免疫耐受性破坏引起的，但其发病是病因因素累积的结果，包括遗传易感性、环境因素和衰老。许多非感染性葡萄膜炎病例在遗传上倾向于人类白细胞抗原 (HLA) 作为最重要的疾病易感区域。 HLA I 类分子对于自然杀伤 (NK) 细胞区分自身和非自身至关重要。杀伤细胞 Ig 样受体 (KIR) 家族是这些受体的重要组成部分之一。越来越多的证据表明，NK 细胞通过与其他免疫活性细胞相互作用而参与先天性和获得性免疫，从而发展出多种自身免疫性疾病。本综述总结了 KIR 在非感染性葡萄膜炎发展中的可能作用。

关键词: NK 细胞、杀伤细胞 Ig 样受体、葡萄膜炎、人类白细胞抗原、免疫特权部位、Vogt-Koyanagi-Harada 病、Behcet 病、急性前葡萄膜炎、鸟瞰脉络膜视网膜病变。

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