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Current Cancer Therapy Reviews

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ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

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Review Article

Triazole as Potent Anti-cancer Agent- A Pharmacophoric Scaffold

Author(s): Nidhi Kala* and Kalpana Praveen Rahate

Volume 18, Issue 2, 2022

Published on: 14 January, 2022

Page: [95 - 117] Pages: 23

DOI: 10.2174/1573394717666211006102147

Price: $65

Abstract

Triazole is the main five-membered Nitrogen-containing basic heterocyclic ring system reported for their biological activities and compounds with multiple pharmacophores, which fetch together acquaintance of a target with sympathetic types of the molecule that might interact with the target. In addition, healthy, adaptable, and scalable chemistry must be employed to achieve the task. This characteristic feature of triazole would make a good template for a lead cohort library. The current review article focuses on recent advancements in triazole moiety as an anti-cancer agent with their mechanism pathways of synthesized analogues.

Keywords: Cytotoxicity, anti-proliferation, MTT assay, click chemistry, caspase-3, 7 and 9, topoisomerase, apoptosis.

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