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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Case Report

Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series

Author(s): Sinan F. Tabanjeh*, Talal Al-Malki , Abdulmajeed R. Alhazzani and Asirvatham A. Robert

Volume 18, Issue 6, 2022

Published on: 12 January, 2022

Article ID: e051021196984 Pages: 6

DOI: 10.2174/1573399817666211005094414

Price: $65

Abstract

Background and Aim: Surgical and endovascular revascularization procedures along with hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) for chronic oxygen-deprived wounds are standard care treatment protocols for diabetic foot ulcer (DFU). Topical developments in the delivery of topical oxygen therapy have made this a more feasible treatment in practice. The present case series highlights the efficacy of NATROX therapy as TOT in wound healing and the impact of increased oxygenation on ulcer healing in patients with diabetic foot ulcers.

Methods: The TOT was evaluated in 6 patients with DFU who have applied NATROX topical oxygen delivery system for a period ranging from 6 weeks to 24 weeks at Kahel Specialized Centre, located in Olaya, Riyadh, Saudi Arabia.

Results: The administration of TOT demonstrated complete wound healing in all the six patients who either had ulcers with minor amputation of toes/heel or had ulcers with other comorbidities in a range from 3 to 8 weeks.

Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large sample size and across the races.

Keywords: Diabetic foot ulcers, diabetes, hyperbaric oxygen therapy, oxygenation topical oxygen therapy, natrox, NATROX therapy.

[1]
International Diabetes Fedaration (IDF). Diabetes Atlas 2019. Available from: https://www.diabetesatlas.org/en/
[2]
Robert AA, Al Dawish MA. The worrying trend of diabetes mellitus in saudi arabia: an urgent call to action. Curr Diabetes Rev 2020; 16(3): 204-10.
[http://dx.doi.org/10.2174/1573399815666190531093735] [PMID: 31146665]
[3]
Al Dawish MA, Robert AA, Braham R, et al. Diabetes mellitus in saudi arabia: a review of the recent literature. Curr Diabetes Rev 2016; 12(4): 359-68.
[http://dx.doi.org/10.2174/1573399811666150724095130] [PMID: 26206092]
[4]
Al-Ayed MY, Ababneh M, Robert AA, Salman A, Al Saeed A, Al Dawish MA. Evaluation of risk factors associated with diabetic foot ulcers in saudi arabia. Curr Diabetes Rev 2019; 15(3): 224-32.
[http://dx.doi.org/10.2174/1573399814666180816165848] [PMID: 30117397]
[5]
Jupiter DC, Thorud JC, Buckley CJ, Shibuya N. The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review. Int Wound J 2016; 13(5): 892-903.
[http://dx.doi.org/10.1111/iwj.12404] [PMID: 25601358]
[6]
Wu SC, Driver VR, Wrobel JS, Armstrong DG. Foot ulcers in the diabetic patient, prevention and treatment. Vasc Health Risk Manag 2007; 3(1): 65-76.
[PMID: 17583176]
[7]
Alzahrani HA. Diabetes-related lower extremities amputations in saudi arabia: the magnitude of the problem. Ann Vasc Dis 2012; 5(2): 151-6.
[http://dx.doi.org/10.3400/avd.oa.11.00098] [PMID: 23555503]
[8]
Everett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann N Y Acad Sci 2018; 1411(1): 153-65.
[http://dx.doi.org/10.1111/nyas.13569] [PMID: 29377202]
[9]
IWGDF. International Working Group on the Diabetic Foot (IWGDF). 2019. Available from: https://iwgdfguidelines.org/wp- content/uploads/2019/05/01-IWGDF-practical-guidelines-2019.pdf
[10]
Castilla DM, Liu ZJ, Velazquez OC. Oxygen: Implications for Wound Healing. Adv Wound Care (New Rochelle) 2012; 1(6): 225-30.
[http://dx.doi.org/10.1089/wound.2011.0319] [PMID: 24527310]
[11]
International Diabetes Fedaration (IDF) Diabetes Atlas; Diabetes Atlas. 2019. Available from: https://www.diabetesatlas.org/en/
[12]
Gottrup F, Dissemond J, Baines C, et al. Use of Oxygen Therapies in Wound Healing. J Wound Care 2017; 26(Sup5): S1-S43.
[13]
Liakos A, Liakopoulou P, Tsapas A. Cyclical pressurized topical wound oxygen therapy increased healing of refractory diabetic foot ulcers. Ann Intern Med 2020; 172(6): JC27.
[http://dx.doi.org/10.7326/ACPJ202003170-027] [PMID: 32176893]
[14]
Kaufman H, Gurevich M, Tamir E, Keren E, Alexander L, Hayes P. Topical oxygen therapy stimulates healing in difficult, chronic wounds: A tertiary centre experience. J Wound Care 2018; 27(7): 426-33.
[http://dx.doi.org/10.12968/jowc.2018.27.7.426] [PMID: 30016136]
[15]
Malone M, Walsh A. Chronic wound infection for the 21st century: perspective review. wound practice & research. J Aus Wound Manageme Associa 2016; 24: 20.
[16]
Harding K. Challenging passivity in venous leg ulcer care - the ABC model of management. Int Wound J 2016; 13(6): 1378-84.
[http://dx.doi.org/10.1111/iwj.12608] [PMID: 27146452]
[17]
Gordillo GM, Sen CK. Evidence-based recommendations for the use of topical oxygen therapy in the treatment of lower extremity wounds. Int J Low Extrem Wounds 2009; 8(2): 105-11.
[http://dx.doi.org/10.1177/1534734609335149] [PMID: 19443899]
[18]
Rao C, Xiao L, Liu H, et al. Effects of topical oxygen therapy on ischemic wound healing. J Phys Ther Sci 2016; 28(1): 118-23.
[http://dx.doi.org/10.1589/jpts.28.118] [PMID: 26957741]
[19]
Bolton L. Does hyperbaric oxygen improve lower extremity ulcer outcomes? Wounds 2020; 32(10): 291-3.
[PMID: 33370247]
[20]
Margolis DJ, Gupta J, Hoffstad O, et al. Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: A cohort study. Diabetes Care 2013; 36(7): 1961-6.
[http://dx.doi.org/10.2337/dc12-2160] [PMID: 23423696]
[21]
Johnston BR, Ha AY, Brea B, Liu PY. The mechanism of hyperbaric oxygen therapy in the treatment of chronic wounds and diabetic foot ulcers. R I Med J 2016; 99(2): 26-9.
[22]
Winfeld B. Topical oxygen and hyperbaric oxygen therapy use and healing rates in diabetic foot ulcers. Wounds 2014; 26: E39-47.
[23]
Mavrogenis AF, Megaloikonomos PD, Antoniadou T, et al. Current concepts for the evaluation and management of diabetic foot ulcers. EFORT Open Rev 2018; 3(9): 513-25.
[http://dx.doi.org/10.1302/2058-5241.3.180010] [PMID: 30305936]
[24]
Curran G, Fisher C, Hayes P, Loftus I, Sequeira L. Case series: the impact of natrox® oxygen wound therapy system on patients with diabetic foot ulcers. Diabetic Foot Journal 2017; 20: 193-7.
[25]
Elg F, Hunt S. Hemoglobin spray as adjunct therapy in complex wounds: meta-analysis versus standard care alone in pooled data by wound type across three retrospective cohort controlled evaluations. SAGE Open Med 2018; 6: 2050312118784313.
[http://dx.doi.org/10.1177/2050312118784313] [PMID: 30013783]
[26]
Dixon D, Edmonds M. Managing diabetic foot ulcers: pharmacotherapy for wound healing. Drugs 2021; 81(1): 29-56.
[http://dx.doi.org/10.1007/s40265-020-01415-8] [PMID: 33382445]
[27]
Hunter P, Greco E, Cross K, Perry J. Topical oxygen therapy shifts microbiome dynamics in chronic diabetic foot ulcers. Wounds 2020; 32(3): 81-5.
[PMID: 32163040]
[28]
Mani R. Topical oxygen therapy for chronic wounds: A report on the potential of natroxTM a new device for delivering enriched oxygen to chronic wounds. J Wound Technol 2010; 9: 28-30.
[29]
Hayes PD, Alzuhir N, Curran G, Loftus IM. Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: A pilot study. J Wound Care 2017; 26(11): 652-60.
[http://dx.doi.org/10.12968/jowc.2017.26.11.652] [PMID: 29131746]
[30]
Yu J, Lu S, McLaren AM, Perry JA, Cross KM. Topical oxygen therapy results in complete wound healing in diabetic foot ulcers. Wound Repair Regen 2016; 24(6): 1066-72.
[http://dx.doi.org/10.1111/wrr.12490] [PMID: 27733020]
[31]
Tang TY, Chong TT, Wang JCC, Choke EC, Nair KR. NATROX®—Let the topical oxygen flow for healing complex wounds.
[32]
Curran G, Hayes PD. 27-years of non-healing wounds—5 patients’ lives transformed by topical oxygen therapy. Poster presentation at Wounds UK Conference.
[33]
Anel E. Consensus round table meeting: Clinical pathway for using topical oxygen therapy in practice. 2017.

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