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Infectious Disorders - Drug Targets

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Systematic Review Article

COVID-19 in Pediatrics: A Systematic Review of Current Knowledge and Practice

Author(s): Esmaeil Mehraeen, Shahram Oliaei, SeyedAhmad SeyedAlinaghi*, Amirali Karimi, Pegah Mirzapour, Amir Masoud Afsahi, Alireza Barzegary, Farzin Vahedi, Mahdi Soleymanzadeh, Farzane Behnezhad, Mohammad Javaherian, Ghazal Zargari, Seyed Peyman Mirghaderi, Tayebeh Noori and Jean-Marc Sabatier

Volume 22, Issue 5, 2022

Published on: 18 April, 2022

Article ID: e290921196908 Pages: 11

DOI: 10.2174/1871526521666210929121705

Price: $65

Abstract

Introduction: SARS-CoV-2 is the novel coronavirus that causes severe acute respiratory syndrome and could afflict individuals from all walks of life. Children are usually asymptomatic or represent non-specific mild to moderate symptoms; therefore, they often remain undiagnosed and could be potential reservoirs and silent carriers of the virus. Despite the global attention to COVID-19 and its importance in public health, some clinical and paraclinical aspects of this disease in children are still unclear. Thus, we conducted a comprehensive systematic review of available literature to reflect on the current knowledge and practice of the disease among children.

Methods: This study was a systematic review of current evidence conducted in October 2020. We performed a systematic search using the keywords in online databases. The investigation adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist to ensure the reliability and validity of extracted literature and results.

Results: We selected and reviewed 23 most related studies out of 1744 identified papers in an initial online search based on the inclusion and exclusion criteria of the present review; of whom 13 were original research studies, and 10 were letters to the editors, commentaries, viewpoints, consensus statements, and perspectives. Although due to the origin of the current pandemic, China was the country with the most publications (12 articles), data from several countries have been included in this review.

Conclusion: COVID-19 can also affect children and cause systemic disease with several internal organ involvements. However, the prevalence, severity, and diversity of the symptoms in children are less than in adults. Cough and fever appear to be some of the most common symptoms, followed by other symptoms such as gastrointestinal manifestations. Comorbidities increase the risk of severe COVID-19 in children, and those without underlying conditions are very unlikely to suffer from severe disease. Mental health issues such as anxiety and depression due to the isolated situation caused by pandemics are common findings in children of early ages and should be seriously considered in current practice.

Keywords: COVID-19, SARS-CoV-2, coronavirus, morbidity, mortality, pediatrics, prognosis.

Graphical Abstract

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