Hemozoin (beta-hematin) Formation Inhibitors: Promising Target for the
Development of New Antimalarials: Current Update and Future Prospect

Suraj   N.   Mali; Anima      Pandey
doi:10.2174/1386207325666210924104036
Abstract

Background: Malaria is responsible for social and economic burden in most lowincome malaria-affected countries. Thus, newer antimalarials are needed to tackle morbidities and mortalities associated with the drug-resistant malarial strains. Haemoglobin digestion inside the food vacuole of malarial parasite would lead to producing redox-active and toxic-free heme. The detoxification process adopted by Plasmodium sp. would give rise to hemozoin (Hz) (betahematin) formation. Targeting the pathway of hemozoin formation is considered a validated target for the discovery of newer antimalarials.
Objective: This study aims to collect detailed information about aspects of hemozoin (Hz) (betahematin) inhibitors.
Methods: A systemic search has been carried out using PubMed, Google Scholar, CNKI, etc., for relevant studies having the keyword, 'hemozoin or beta-hematin' for almost the last 2 decades (2000-2021).
Results: This review tries to summarize all the recent advancements made for the developments of synthetic, natural isolated phytoconstituents and plant extracts inhibiting the hemozoin (betahematin) formation.
Conclusion: Thus they would act as promising antimalarial candidates in the near future.
Keywords: SOX9, IL1A, potential gene, biomarkers, oral cancer, bioinformatics.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1386207325666210924104036	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402
Combinatorial Chemistry & High Throughput Screening

Hemozoin (beta-hematin) Formation Inhibitors: Promising Target for the Development of New Antimalarials: Current Update and Future Prospect

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