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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

Author(s): Lucas Alexandre Santos Marzano, Fabyolla Lúcia Macedo de Castro, Caroline Amaral Machado, João Luís Vieira Monteiro de Barros, Thiago Macedo e Cordeiro, Ana Cristina Simões e Silva, Antônio Lúcio Teixeira and Aline Silva de Miranda*

Volume 29, Issue 19, 2022

Published on: 07 January, 2022

Page: [3392 - 3419] Pages: 28

DOI: 10.2174/0929867328666210923143713

Price: $65

Abstract

Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.

Keywords: Traumatic brain injury, neurogenesis, hippocampus, models, animal, dentate gyrus, therapeutics.

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