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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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Review Article

The Role of miR-129-5p in Cancer: A Novel Therapeutic Target

Author(s): Shan Xu, Wei Li, Jing Wu, Yuru Lu, Ming Xie, Yanlan Li, Juan Zou, Tiebing Zeng* and Hui Ling*

Volume 15, Issue 4, 2022

Published on: 12 January, 2022

Article ID: e140921196477 Pages: 11

DOI: 10.2174/1874467214666210914122010

Price: $65

Abstract

miRNA-129-5p belongs to the microRNA-129 (miRNA-129) family. miRNA-129-5p is expressed in many tissues and organs of the human body, and it regulates a wide range of biological functions. The abnormal expression of miRNA-129-5p is related to the occurrence and development of a variety of malignant tumors. miRNA-129-5p plays an important role in the tumorigenesis process and functions by promoting or inhibiting tumors. However, the role of miRNA-129-5p in cancer remains controversial. This article reviews the different biological functions of miRNA- 129-5p in cancer and provides ideas for research in this field to guide the development of targeted therapies and drugs for malignant tumors.

Keywords: miR-129-5p, cancer, growth, development, clinical implications, therapeutic target, chemotheraptic drugs.

Graphical Abstract

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