Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents

Title:Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents

Volume: 21 Issue: 23

Author(s): Nisha Poonia, Aman Kumar, Vijay Kumar, Monika Yadav and Kashmiri Lal*

Affiliation:

• Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001,India

Keywords: 1, 2, 3-triazole, Click reaction, CuAAC, Antifungal activity, Triazole hybrids, fungal infections.

Abstract: The need to overcome ever-increasing cases of antifungal resistance and circumvent side effects and drug interactions related to currently available drugs has impelled the demand to expedite the drug discovery and the development of novel antifungals. 1,4-disubstituted 1,2,3-triazole has gained tremendous interest in the last two decades mainly because of its ease of synthesis via copper( I)-catalyzed azide-alkyne cycloaddition (CuAAC) and its broad spectrum of chemotherapeutic potential. 1,2,3-Triazole is an excellent pharmacophore that has been used as a bioisostere for obtaining libraries of new medicinally important scaffolds. The present review focuses on the recent advances (2016-2021) in 1,2,3-triazole derivatives obtained by CuAAC as potential antifungal agents that may facilitate the triazole-based antifungal development process.

Cite this article as:

Poonia Nisha , Kumar Aman , Kumar Vijay , Yadav Monika and Lal Kashmiri *, Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents, Current Topics in Medicinal Chemistry 2021; 21 (23) . https://dx.doi.org/10.2174/1568026621666210913122828