Login Register Cart 0
Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Case Report

Complete Healing and Short-term Treatment by Argania Honey Dressing in a Venous Leg Ulcer: A Case Report

Author(s): Leila Khattabi , Kawtar Raghay*, Mohamed Dakkach and Mohamed Allouch

Volume 8, Issue 2, 2022

Published on: 18 January, 2022

Article ID: e130921196412 Pages: 5

DOI: 10.2174/2215083807666210913105216

Price: $65

conference banner
Abstract

Background: Recent advances in care show that inadequate management of the healing process in wounds and the development of bacterial infections lead to increased morbidity. Health professionals have progressively recognized the value of choosing suitable dressings to manage wounds, particularly in developing countries. Honey has been used for thousands of years as a wound dressing and is considered a biologic treatment due to its multiple bioactivities related to the healing process.

Objective: The aim of this case report is to demonstrate that Argania Honey dressing improves the healing process in a venous leg ulcer.

Methods: Pure raw Argania honey (Argania spinosa, endemic tree in Southwestern Morocco) with no additives, pasteurization or manipulation was used, which was provided by local beekeepers. A mechanical debridement process was achieved previously to the application of honey dressings to a venous leg ulcer of a 67-year-old woman affected by type II diabetes for 11 years.

Results: The Argania honey dressing accompanied by mechanical debridement process demonstrated a rapid recovery and complete healing of the wound for 12 weeks approximately (79 days).

Conclusion: This Moroccan honey (Argania) experienced for the first time in venous leg ulcer management may represent a good alternative to treat other types of wounds. Further investigations by using Argania honey dressing are required to explain its effect and the mechanisms involved in the improvement of the healing process.

Keywords: Healing, honey dressing, venous leg ulcer, diabetes, argania honey, wounds, case report.

Graphical Abstract

[1]
Graves N, Zheng H. The prevalence and incidence of chronic wounds: A literature review. Wound Pract Res J Aust Wound Manag Assoc 2014; 22: 4-12.
[2]
Dini V, Janowska A, Oranges T, De Pascalis A, Iannone M, Romanelli M. Surrounding skin management in venous leg ulcers: A systematic review. J Tissue viability 2020; 29(3): 169-75.
[http://dx.doi.org/10.1016/j.jtv.2020.02.004] [PMID: 32151489]
[3]
Raffetto JD, Ligi D, Maniscalco R, Khalil RA, Mannello F. Why venous leg ulcers have difficulty healing: overview on pathophysiology, clinical consequences, and treatment. J Clin Med 2020; 10(1): 29.
[http://dx.doi.org/10.3390/jcm10010029] [PMID: 33374372]
[4]
Rice JB, Desai U, Cummings AKG, Birnbaum HG, Skornicki M, Parsons N. Burden of venous leg ulcers in the United States. J Med Econ 2014; 17(5): 347-56.
[http://dx.doi.org/10.3111/13696998.2014.903258] [PMID: 24625244]
[5]
Margolis DJ, Knauss J, Bilker W. Medical conditions associated with venous leg ulcers. Br J Dermatol 2004; 150(2): 267-73.
[http://dx.doi.org/10.1111/j.1365-2133.2004.05773.x] [PMID: 14996097]
[6]
Ren S-Y, Liu Y-S, Zhu G-J, et al. Strategies and challenges in the treatment of chronic venous leg ulcers. World J Clin Cases 2020; 8(21): 5070-85.
[http://dx.doi.org/10.12998/wjcc.v8.i21.5070] [PMID: 33269244]
[7]
Hess CT. Venous ulcer assessment and management: Using the updated CEAP classification system. Adv Skin Wound Care 2020; 33(11): 614-5.
[http://dx.doi.org/10.1097/01.ASW.0000719052.33284.73] [PMID: 33065684]
[8]
Kelechi TJ, Brunette G, Bonham PA, et al. Guideline for management of wounds in patients with lower-extremity venous disease (LEVD): An executive summary. J Wound Ostomy Continence Nurs 2020; 47(2): 97-110.
[http://dx.doi.org/10.1097/WON.0000000000000622] [PMID: 32150136]
[9]
Pugliese DJ. Infection in venous leg ulcers: considerations for optimal management in the elderly. Drugs Aging 2016; 33(2): 87-96.
[http://dx.doi.org/10.1007/s40266-016-0343-8] [PMID: 26833351]
[10]
Ligi D, Mosti G, Croce L, Raffetto JD, Mannello F. Chronic venous disease - Part I: Inflammatory biomarkers in wound healing. Biochim Biophys Acta 2016; 1862(10): 1964-74.
[http://dx.doi.org/10.1016/j.bbadis.2016.07.018] [PMID: 27478145]
[11]
Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev 2015; 2015(6): CD004123.
[http://dx.doi.org/10.1002/14651858.CD004123.pub4] [PMID: 26106870]
[12]
O’Donnell TF Jr, Passman MA, Marston WA, et al. Management of venous leg ulcers: Clinical practice guidelines of the society for vascular surgery ® and the American venous forum. J Vasc Surg 2014; 60(2): 3S-59S.
[http://dx.doi.org/10.1016/j.jvs.2014.04.049] [PMID: 24974070]
[13]
Bonkemeyer Millan S, Gan R, Townsend PE. Venous ulcers: Diagnosis and treatment. Am Fam Physician 2019; 100(5): 298-305.
[PMID: 31478635]
[14]
Holland LC, Norris JM. Medical grade honey in the management of chronic venous leg ulcers. Int J Surg 2015; 20: 17-20.
[http://dx.doi.org/10.1016/j.ijsu.2015.05.048] [PMID: 26050953]
[15]
Tellechea A, Teixeira V. Efficacy of honey gel in the treatment of chronic lower leg ulcers: A prospective study EWMA J 2013; 13: 35-9.
[16]
Herrera-Jiménez C, Lorenzo-Ruiz H, Domínguez-Martís EM, Novío S. Successful treatment of a venous leg ulcer with manuka honey. J Wound Ostomy Continence Nurs 2021; 48: 79-82.
[http://dx.doi.org/10.1097/WON.0000000000000712]
[17]
Poljšak N, Kreft S, Kočevar Glavač N. Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology. Phytother Res 2020; 34: 254-69.
[http://dx.doi.org/10.1002/ptr.6524] [PMID: 31657094]
[18]
Avsar U, Halici Z, Akpinar E, et al. The effects of argan oil in second-degree burn wound healing in rats. Ostomy Wound Manage 2016; 62: 26-34.
[PMID: 26978857]
[19]
Oryan A, Alemzadeh E, Moshiri A. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. J Tissue Viability 2016; 25: 98-118.
[http://dx.doi.org/10.1016/j.jtv.2015.12.002] [PMID: 26852154]
[20]
Mphande a NG, Killowe C, Phalira S, Jones HW, Harrison WJ. Effects of honey and sugar dressings on wound healing. J Wound Care 2007; 16: 317-9.
[http://dx.doi.org/10.12968/jowc.2007.16.7.27053] [PMID: 17708384]
[21]
Wang C, Guo M, Zhang N, Wang G. Effectiveness of honey dressing in the treatment of diabetic foot ulcers: A systematic review and meta-analysis. Complement Ther Clin Pract 2019; 34: 123-31.
[http://dx.doi.org/10.1016/j.ctcp.2018.09.004] [PMID: 30712715]
[22]
Tonks AJ, Dudley E, Porter NG, et al. A 5.8-kDa component of manuka honey stimulates immune cells via TLR4. J Leukoc Biol 2007; 82: 1147-55.
[http://dx.doi.org/10.1189/jlb.1106683] [PMID: 17675558]
[23]
Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol 2010; 19: 73-9.
[http://dx.doi.org/10.1111/j.1600-0625.2009.00994.x] [PMID: 19845754]
[24]
Moghazy AM, Shams ME, Adly OA, et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract 2010; 89: 276-81.
[http://dx.doi.org/10.1016/j.diabres.2010.05.021] [PMID: 20646771]
[25]
Barui A, Banerjee P, Das RK, Basu SK, Dhara S, Chatterjee J. Immunohistochemical Evaluation of p63, E-Cadherin, Collagen I and III Expression in Lower Limb Wound Healing under Honey. Evid Based Complement Alternat Med 2011; 2011: 1-8.
[http://dx.doi.org/10.1155/2011/239864] [PMID: 21584268]
[26]
Sood A, Granick MS, Tomaselli NL. Wound Dressings and Comparative Effectiveness Data. Adv Wound Care (New Rochelle) 2014; 3: 511-29.
[http://dx.doi.org/10.1089/wound.2012.0401] [PMID: 25126472]
[27]
Conte MS, Bradbury AW, Kolh P, et al. Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia. Eur J Vasc Endovasc Surg 2019; 58:S1-S109.e33.
[http://dx.doi.org/10.1016/j.ejvs.2019.05.006] [PMID: 31182334]
[28]
Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther 2017; 34: 599-610.
[http://dx.doi.org/10.1007/s12325-017-0478-y] [PMID: 28108895]
[29]
Hunt TK, Hopf HW. Wound healing and wound infection: What surgeons and anesthesiologists can do. Surg Clin North Am 1997; 77: 587-606.
[http://dx.doi.org/10.1016/S0039-6109(05)70570-3] [PMID: 9194882]
[30]
Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 2006; 70: 1469-80.
[http://dx.doi.org/10.1124/mol.106.027029] [PMID: 16887934]
[31]
Jones V, Grey JE, Harding KG. Wound dressings. BMJ 2006; 332: 777-80.
[http://dx.doi.org/10.1136/bmj.332.7544.777] [PMID: 16575081]

Rights & Permissions Print Cite
Article Metrics
17
1
© 2024 Bentham Science Publishers | Privacy Policy