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ISSN (Online): 2215-0846

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Review Article

Neuroprotective Activities of Orientin: A Review

Author(s): Deepak Vasudevan Sajini, Praveen Thaggikuppe Krishnamurthy* and Amritha Chakkittu Kandiyil

Volume 8, Issue 1, 2022

Published on: 14 January, 2022

Article ID: e130921196409 Pages: 11

DOI: 10.2174/2215083807666210913104505

Price: $65

Abstract

Orientin is a flavonoid C-glycoside found in many plants, and studies investigating its neuropharmacological benefits have received significant attention in recent years. Orientin has modulating effects on various neuropathological pathways such as Nrf2-ARE, PI3K/Akt, JNKERK1/ 2, and TLR4/NF-kB. Orientin, therefore, is evaluated for its benefits in various neurodegenerative diseases such as Alzheimer's and Huntington's disease. This paper reviews Orientin's neuroprotective mechanisms and benefits.

Keywords: Orientin, Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, TLR4/NF-kB, neuroprotection.

Graphical Abstract

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