Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Review Article

Wheatgrass: An Epitome of Nutritional Value

Author(s): Neha Minocha, Nidhi Sharma and Parijat Pandey*

Volume 18, Issue 1, 2022

Published on: 06 September, 2021

Page: [22 - 30] Pages: 9

DOI: 10.2174/1573401317666210906140834

Price: $65

Abstract

Abstract: Plants having active constituents possess pharmaceutical use and nutritional values. Herbal medicine or food supplement is gaining popularity, as well as scientific research on wheatgrass as a “functional food”.

The target behind accepting wheatgrass as a study for review is to have clinical and nonclinical investigations on the wheatgrass plant at an equivalent stage. To let individuals, think about different affirmed uses and activities of the plant.

Plants having so many nutritional and therapeutic values have been selected for review so that consumers or patients could be benefitted from their therapeutic uses. Recently, the interests in the use of herbal products have grown dramatically in the western as well as developing countries. The review was extracted from searches performed on Google Scholars, Google Patents, etc. Data from sources have been collected and reported here at one place in order to provide further research on wheatgrass.

Wheatgrass is a high source of various vitamins and minerals; it possesses many activities like anti-oxidant, anti-inflammation, anti-bacterial and many more. Wheatgrass’ uses, benefits and properties non-clinical data and clinical studies has been thoroughly studied. Patents filed related to wheatgrass are mentioned here, so as to motivate other innovators to search for new activities or molecules.

Wheatgrass can be used in pharmaceutical formulations and can be used as nutritional supplements due to its anti-oxidant nature, anti-microbial activity, anti-bacterial activity, anti-fungal activity. It is also called “Panacea on Earth” owing to its wide range of nutritive and medicinal aspects.

Keywords: Wheatgrass, Triticum aestivum, chlorophyll, thalassemia, anti-cancer, anti-oxidative.

Graphical Abstract

[1]
Shah KV, Desai TR. Formulation and evaluation of wheatgrass topical gel. Pharma Sci Monitor 2012; 3(4): 3010-7.
[2]
Sundaresan A, Selvi A, Manonmani HK. The Anti-Microbial properties of Triticum aestivum (Wheat Grass) Extract. Int J Biotechnol Wellness Ind 2015; 4: 84-91.
[http://dx.doi.org/10.6000/1927-3037.2015.04.03.1]
[3]
Kumar SV. Satish.; C, Ravi.; S, Rahul.; G, Usha.; Vaidya, S.K. A review on wheat grass. IJPI’s J. Pharmacogn Herbal Formul 2011; 1(4): 93-103.
[4]
Sandhiya V, Ubaidulla U. A review on herbal drug loaded into pharmaceutical carrier techniques and its evaluation process. Future J Pharm Sci 2020; 6: 51-63.
[http://dx.doi.org/10.1186/s43094-020-00050-0]
[5]
Pascuzzi M, Chambers C. Does wheatgrass juice oxygenate the blood of resting individuals? The Internet J Altern Med 2008; 7(2): 1-15.
[6]
Bar-Sela G, Cohen M, Ben-Arye E, Epelbaum R. The medical use of wheatgrass: Review of the gap between basic and clinical applications. Mini Rev Med Chem 2015; 15(12): 1002-10.
[http://dx.doi.org/10.2174/138955751512150731112836] [PMID: 26156538]
[7]
Devi CB, Chatli MK, Bains K, Kaur H. Rindhe. Enrichment of wheatgrass (Triticum aestivum L) juice and powder in milk and meat-based food products for enhanced antioxidant potential. Int J Curr Microbiol Appl Sci 2019; 8(06): 3259-68.
[http://dx.doi.org/10.20546/ijcmas.2019.806.388]
[8]
Aydos O, Avci A, Ozkan T, Karadag A, Gurleyik E. Antiproliferative, apoptotic and antioxidant activities of wheatgrass (Triticum aestivum L.) extract on CML (K562) cell line. Turk J Med Sci 2011; 41(4): 657-63.
[9]
Elif A, Mete K, Onder ON, Alperen K, Betul S, Oztop MH. Wheatgrass juice to wheat grass powder: Encapsulation, physical and chemical characterization. J Funct Foods 2016; 28: 19-27.
[10]
Thakur N, Dhaliwal HS, Sharma V. Chemical composition, minerals and vitamins analysis of lyophilized wheatgrass juice powder. Int J Emerg Technol 2019; 10(4): 137-44.
[11]
Sun TY, Li JS, Chen C. Effects of blending wheatgrass juice on enhancing phenolic compounds and antioxidant activities of traditional kombucha beverage. J Food Drug Anal 2015; 23(4): 709-18.
[http://dx.doi.org/10.1016/j.jfda.2015.01.009] [PMID: 28911487]
[12]
Chauhan M. A pilot study on wheat grass juice for its phytochemical, nutritional and therapeutic potential on chronic diseases. Int J Chem Stud 2014; 2(4): 27-34.
[13]
Mujoriya R, Bodla RB. A study on wheatgrass and its nutritional value. Food Sci Qual Manag 2011; 2: 1-8.
[14]
Paolo B, Giacomo T, Michela F, et al. Phenolic content and antioxidant activity of einkorn and emmer sprouts and wheatgrass obtained under different radiation wavelengths. Ann Agric Sci 2020; 65(1): 68-76.
[http://dx.doi.org/10.1016/j.aoas.2020.02.001]
[15]
Kumar NS, Murali M, Nair AM, Nair AS. Green blood therapy of wheatgrass – Nature’s finest medicine. A literature review. IOSR J Pharm Biol Sci 2016; 11(2): 57-64.
[16]
Nandedkar PH, Khandare SA. Synthesis of silver nanoparticles from wheatgrass extract and its biological applications. Int J Chem Stud 2018; 6(3): 113-6.
[17]
Dutta AK, Wasim R. Wheat grass- a perfect food and its anti-microbial properties from the different solvent extract. World J Pharm Pharm Sci 2016; 5(9): 1818-28.
[18]
Das A, Raychaudhuri U, Chakraborty R. Antimicrobial effect of edible plant extract on the growth of some foodborne bacteria including pathogens. Nutrafoods 2012; 12: 83-8.
[http://dx.doi.org/10.1007/s13749-012-0033-z]
[19]
Dhaliwal HS, Sharma N, Bano A, Kumar S, Sharma V. Non-enzymatic assay based in-vitro antioxidant activity and phytochemical screening of freeze-dried wheat (Triticum Aestivum L.) seedlings juice powder: nature’s finest medicine-part- II. Int J Pharm Sci Res 2015; 6(9): 4036-46.
[20]
Durairaj V, Hoda M, Shakya G, Babu SPP, Rajagopalan R. Phytochemical screening and analysis of antioxidant properties of aqueous extract of wheatgrass Asian Pac J Trop Med 2014; 7S1(1): S398-404.
[http://dx.doi.org/10.1016/S1995-7645(14)60265-0] [PMID: 25312157]
[21]
Ashok SA. Phytochemical and pharmacological screening of wheatgrass juice (Triticum aestivum L.). Int J Pharm Sci Rev Res 2011; 9: 159-64.
[22]
Gahan E, Kline P, Finkle T. Chlorophyll in the treatment of ulcers. Derm & Syph 1943; 47: 849-51.
[http://dx.doi.org/10.1001/archderm.1943.01500240089014]
[23]
Prasanna SGV, Gayathri R, Vishnu P. Anti-fungal activity of wheat grass extract. Int J Pharm Sci Rev Res 2016; 39(1): 237-9.
[24]
Ben-Arye E, Goldin E, Wengrower D, Stamper A, Kohn R, Berry E. Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002; 37(4): 444-9.
[http://dx.doi.org/10.1080/003655202317316088] [PMID: 11989836]
[25]
Mutha AS, Shah KU, Kinikar AA, Ghongane BB. Efficacy and safety of wheat grass in thalassaemic children on regular blood transfusion. Cureus 2018; 10(3)e2306
[PMID: 29755902]
[26]
Matés JM, Sánchez-Jiménez FM, Fransisca M. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 2000; 32(2): 157-70.
[http://dx.doi.org/10.1016/S1357-2725(99)00088-6] [PMID: 10687951]
[27]
Livingston. Abscisic acid tablets and process. US Patent. 395-8025 1976.
[28]
Samagandi K, Sharma J, Kumar S, Tripathy TB. A clinical study on the efficacy of wheatgrass juice in prameha. Int Res J Pharm 2012; 3(4): 194-9.
[29]
Abd-Alhadi IHAJ, Adnan MAA, Mwaffuk HAAJ. Effect of wheatgrass and spirulina as nutrition supplement on some physiological and biochemical parameters in lactating female rats. Plant Arch 2019; 19(2): 4274-8.
[31]
Hesham AE, Sherif SM, Ahmed MSH. Nutritional value and impact of wheatgrass juice (Green Blood Therapy) on increasing fertility in male albino rats. Bull Natl Res Cent 2020; 44: 30-44.
[http://dx.doi.org/10.1186/s42269-020-0272-x]
[32]
Best CH, Ridout JH. The effects of cholesterol and choline on deposition of liver fat. J Physiol 1933; 78(4): 415-8.
[http://dx.doi.org/10.1113/jphysiol.1933.sp003013] [PMID: 16994430]
[33]
Khan N, Ganeshpurkar A, Dubey N, Bansal D. Immunoprophylactic potential of wheat grass extract on benzene-induced leukemia: An in vivo study on murine model. Indian J Pharmacol 2015; 47(4): 394-7.
[http://dx.doi.org/10.4103/0253-7613.161261] [PMID: 26288471]
[34]
Desai TR. Investigation into the mechanism of action and effects of Triticum Aestivum (Wheat). Grass 2005.
[35]
Marawaha RK, Bansal D, Kaur S, Trehan A. Wheat grass juice reduces transfusion requirement in patients with thalassemia major: a pilot study. Indian Pediatr 2004; 41(7): 716-20.
[PMID: 15297687]
[36]
Marie CRS, Shreef GNG, Gamal NG. Beneficial effect of wheatgrass juice on some biochemical parameters in Type 2 diabetic subjects with reduced lymphocytes count. Res J Pharm Biol Chem Sci 2017; 8(1): 1952-60.
[37]
Chawla P, Kaur D. Sunaina; Kaur, G.; Shah, G.; Chawla, A.; Dhawan, R.K. Wheat grass: A review on pharmacognosy and pharmacological aspects. Int J Phytopharmcol 2015; 6(2): 80-5.
[38]
Tachino N, Guo D, Dashwood WM, Yamane S, Larsen R, Dashwood R. Mechanisms of the In vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res 1994; 308(2): 191-203.
[http://dx.doi.org/10.1016/0027-5107(94)90154-6] [PMID: 7518046]
[39]
Guengerich FP, Kim DH, Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 1991; 4(2): 168-79.
[http://dx.doi.org/10.1021/tx00020a008] [PMID: 1664256]
[40]
Singh N, Verma P, Pandey BR. Therapeutic potential of organic triticum aestivum linn. (wheat grass) in prevention and treatment of chronic diseases: An overview. Int J Pharm Sci Drug Res 2012; 4(1): 10-4.
[41]
Rani N, Khajuria V, Tandon VR, Sharma R. Evaluation of wheat grass in preventing haematological toxicity related to chemotherapy in breast cancer patients. J Adv Med Dental Sci Res 2019; 7(9): 85-9.
[42]
Avisar A, Cohen M, Katz R, Shentzer Kutiel T, Aharon A, Bar-Sela G. Wheatgrass juice administration and immune measures during adjuvant chemotherapy in colon cancer patients: Preliminary results. Pharmaceuticals (Basel) 2020; 13(6): 129-41.
[http://dx.doi.org/10.3390/ph13060129] [PMID: 32585974]
[43]
Bar-Sela G, Tsalic M, Fried G, Goldberg H. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: a pilot study. Nutr Cancer 2007; 58(1): 43-8.
[http://dx.doi.org/10.1080/01635580701308083] [PMID: 17571966]
[44]
Avisar A, Cohen M, Brenner B, et al. Extracellular vesicles reflect the efficacy of wheatgrass juice supplement in colon cancer patients during adjuvant chemotherapy. Front Oncol 2020; 10: 1659-70.
[http://dx.doi.org/10.3389/fonc.2020.01659] [PMID: 32984039]
[45]
Mukhopadhyay S, Basak J, Kar M, Mandal S, Mukhopadhyay A. The role of iron chelation activity of wheat grass juice in patients with myelodysplastic syndrome. J Clin Oncol 2009; 7012: 1-18.
[46]
Swati AS. Extraction of a new ketone compound from wheatgrass juice triticum aestivum (l), exhibiting both anti-cancer and immunomodulatory bioactivity. 201721033651, 2017.
[47]
Lee YM, Kim DK, Lee SH. Composition for treating and preventing obesity, containing wheatgrass as active ingredient. 20140308377 2014.
[48]
Sagliano FS, Elizabeth A S. Method for growing and preserving wheatgrass nutrients and products thereof. 5820916, 1998.
[49]
Padalia S, Drabu S, Raheja I, Gupta A, Dhamija M. Multitude potential of wheatgrass juice (Green Blood): An overview. Chron Young Scient 2010; 1(2): 23-8.
[50]
Tangahu BV, Abdullah SRS, Basri H, Idris M, Anuar N, Mukhlisin M. A review on heavy metals (As, Pb, and Hg) uptake by plants through phytoremediation. Int J Chem Eng 2011; 11: 1-15.
[http://dx.doi.org/10.1155/2011/939161]
[51]
Yun L, Jensen KB, Larson SR. Accumulation of metals in native wheatgrasses and wild ryes when grown on metal-contaminated soil from three mine sites in Montana. J Agricultural Sci Botany 2018; 2(1): 19-24.
[http://dx.doi.org/10.35841/2591-7897.2.1.19-24]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy