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Review Article

组蛋白去乙酰化酶10的选择性抑制剂（HDAC-10）

卷 29, 期 13, 2022

发表于: 01 September, 2021

页: [2306 - 2321] 页: 16

弟呕挨: 10.2174/0929867328666210901144658

价格: $65

摘要

组蛋白乙酰化平衡是一种控制与疾病进展相关的基因表达的表观遗传机制。已经观察到组蛋白脱乙酰酶10（HDAC-10）同工酶有助于化疗耐药性;此外，在侵袭性实体瘤（如神经母细胞瘤）患者中观察到的不良临床结果与其过表达有关。此外，HDAC-10选择性抑制抑制自噬反应，因此与细胞毒性癌症化疗药物相比，提供了更好的风险 - 益处。在这些基础上，HDAC-10正在成为药物设计的新兴目标。由于下一代HDAC抑制剂的开发进展迅速，本文旨在概述新型选择性或双HDAC-8/10抑制剂作为癌症化疗的新先导物，能够避免几种实际批准的“泛”HDAC抑制剂的严重副作用。从2015年至今，在MedLine，PubMed，Caplus，SciFinder Scholar数据库中进行了文献检索。由于HDAC-6抑制剂Tubastatin A能够有效地结合HDAC-10，因此合成并测试了几种相关的类似物。同时考虑了三环（25-30）和双环（31-42）衍生物。36个显示出最佳的药理学特征（HDAC-10 pIC50 = 8.4，pIC50对I类HDACs从5.2-6.4）。同时，基于高水平的HDAC-8是神经母细胞瘤治疗预后不良的标志物的证据，设计了双HDAC-8 / 10抑制剂。羟肟酸TH34（HDAC-8和10 IC50 = 1.9 μM和7.7 μM）和杂化衍生物46d、46e和46g在效力和选择性方面均最有前途。文献调查表明，对HDAC-10的抑制效力和选择性有几种结构要求，例如，静电和/或氢键与E274的相互作用以及与P（E，A）CE基序螺旋的互补性。

关键词: HDAC-10，同工酶选择性抑制剂，抗肿瘤药，神经母细胞瘤，图巴他汀A，PCI-34051。

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