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Review Article

谷氨酸脱氢酶作为高胰岛素血症高氨血症综合征治疗的有希望的靶点

卷 29, 期 15, 2022

发表于: 05 January, 2022

页: [2652 - 2672] 页: 21

弟呕挨: 10.2174/0929867328666210825105342

价格: $65

摘要

高胰岛素血症 - 高氨血症综合征（HHS）是一种罕见的疾病，其特征是复发性低血糖和血浆氨持续升高，可导致严重癫痫和永久性脑损伤。已经证明，谷氨酸脱氢酶 (GDH) 是线粒体基质中的一种酶，其功能突变是造成 HHS 的原因。因此，GDH已成为HHS小分子治疗干预的有希望的靶点。目前有几项药物化学研究针对GDH，然而，迄今为止，所报道的化合物均未进入临床试验。本文综述了GDH抑制剂的发现和开发进展，包括HHS的发病机制、潜在结合位点、筛选方法和研究模型。提供未来的治疗视角，为发现有效的GDH调节剂提供参考，并鼓励更多的研究，为药物开发提供更全面的指导。

关键词: 高胰岛素血症综合征（HHS），谷氨酸脱氢酶（GDH），筛选方法，酶抑制剂，药物发现，体外/体内模型。

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